Asst Prof Lu Shengjie

Dr. Lu Shengjie is an Assistant Professor in the SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme (CVS ACP) and the Cardiovascular and Metabolic Disorders Programme (CVMD) at Duke-NUS Medical School, and a Junior Principal Investigator at the National Heart Research Institute Singapore (NHRIS). He also serves as lead in the core of Translational Biomedical Imaging, Biomechanics, and Biomaterials at the College of Healthcare Engineering, SingHealth Duke-NUS Academic Medical Centre (AMC).

His research focus is on developing innovative biomaterial-based therapeutic solutions for cardiovascular diseases such as myocardial infarction (MI) and heart failure. He has established a translational nanomedicine platform, leveraging nanotechnology and targeted strategies to deliver a variety of therapeutic agents, including small molecules, peptides, RNA, and genes, specifically for heart disease treatment.

Also, he is passionate about advancing medical technologies. His interests include intravascular imaging and medical device innovations, particularly in catheter delivery systems like drug-eluting stent (DES) and drug-coated balloon (DCB). Over the past years, he has led multiple translational research projects with direct clinical healthcare impacts, and continues to expand the biomaterials platform for diverse bench-to-bedside innovations, together with clinicians, basic science researchers, and healthcare engineers throughout the SingHealth Duke-NUS system.

Dr. Lu has secured several grants and authored over 20 publications, editorials, and book chapters. He has played active roles in both local and international collaborations, building strong links with industrial and academic partners.

Phd, National University of Singapore (NUS), 2016

MSc, Beijing University of Chemical Technology, 2009

BSc, Beijing University of Chemical Technology,  2006

Junior Principal Investigator, National Heart Research Institute Singapore (NHRIS), NHCS

Asst Prof, Cardiovascular Sciences Academic Clinical Programme (CVS ACP), Duke-NUS Medical School;

Asst Prof, Cardiovascular and Metabolic Disorders Programme (CVMD), Duke-NUS Medical School.

Lead, Translational Biomedical Imaging, Biomechanics, & Biomaterials, College of Healthcare Engineering, SingHealth Duke-NUS Academic Medical Centre (AMC).

Khoo Postdoctoral Fellowship Award, 2018

Best Paper Award, Singapore Cardiac Society 30th Annual Scientific Meeting, 2018

1.       Crespo-Avilan GE, Hernandez Resendiz S, Ramachandra CJ, Ungureanu V, Lin Y-H, Lu S, Bernhagen J, Bounkari OE, Preissner KT, Liehn EA, Hausenloy DJ. Metabolic reprogramming of immune cells by mitochondrial division inhibitor-1 to prevent post-vascular injury neointimal hyperplasia. Atherosclerosis. 2024, 390, 117450.

2.      Hernandez Resendiz S, Prakash A, Semenzato M, Chinda K, Crespo-Avilan GE, Dam LC, Lu S, Scorrano L, Hausenloy DJ. Targeting mitochondrial shape: at the heart of cardioprotection. Basic Research in Cardiology. 2023, 118(1), 49.

3.      Toh HW, Toong DWY, Ng JCK, Ow V, Lu S, Tan LP, Wong PEH, Venkatraman S, Huang Y, Ang HY. Polymer blends and polymer composites for cardiovascular implants. European Polymer Journal. 2021, 110249.

4.      Gasior P*, Lu S*, Ng CKJ, Toong WYD, Wong EHP, Foin N, Kedhi E, Wojakowski Wojciech, Ang HY. Comparison of overexpansion capabilities and thrombogenicity at the side branch ostia after implantation of four different drug eluting stents. Scientific Reports 2020; 10 (1), 1-11 (*Co-first author)

5.      Mendez-Fernandez A, Cabrera-Fuentes HA, Velmurugan B, Irei J, Boisvert WA, Lu SJ^#, Hausenloy DJ^#. Nanoparticle delivery of cardioprotective therapies. Conditioning Medicine 2020; 3(1):18-30. (^# Corresponding author)

6.      Mullapudi SS, Zhang J, Lu S, Rahmat JN, Mahendran R, Kang E-T, Chiong E, Neoh KG. Receptor-Targeting Drug and Drug Carrier for Enhanced Killing Efficacy against Non-Muscle-Invasive Bladder Cancer. ACS Appl Bio Mater. 2019; 2 (9): 3763-3773

7.      Lu SJ, Ng J, Ang HY, Paradies V, Wong P, Al-Lamee R, Al-Lamee K, Bullett N, Ahmed N, Joner M and Foin N. Is There Light at the End of the Thin-Strut Tunnel? In Vitro Insights on Strut Thickness Impact on Thrombogenicity in Bioresorbable Stents or Scaffolds. JACC: Cardiovascular Interventions. 2018;11(7):714-716.

8.      Paradies V*, Lu SJ*, Ng J, Ang HY, Joner M and Foin N. Thrombogenicity at the jailed side branch ostia in provisional stenting technique: insights from an in vitro model. EuroIntervention 2018; 14(7):826-827. (*Co-first author)

9.      Foin N, Lu SJ, Ng J, Bulluck H, Hausenloy DJ, Wong PE, Virmani R, Joner M. Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in-vitro model. EuroIntervention 2017;13:e1096-e1098.

10.   Ong SB, Lu SJ, Katwadi K, Ismail NI, Kwek XY, Hausenloy DJ. Nanoparticle delivery of mitoprotective agents to target ischemia heart disease. Future Cardiology 2017; 13(3):195-198.

11.   Lu SJ, Xu LQ, Kang ET, Mahendran R, Chiong E, Neoh KG. Co-delivery of peptide-modified cisplatin and doxorubicin via mucoadhesive nanocapsules for potential synergistic intravesical chemotherapy of non-muscle-invasive bladder cancer. Eur J Pharm Sci. 2016;84: 103–115.

12.   Neoh KG, Lu SJ, Kang ET, Mahendran R, Chiong E. Tailoring Soft Nanoparticles for Potential Application as Drug Carriers in Bladder Cancer Chemotherapy. Nanotechnology: Delivering on the Promise Volume 2: American Chemical Society; 2016. p. 167-95. (Book Chapter).

13.   Lu SJ, Neoh KG, Kang ET, Mahendran R, Chiong E. Mucoadhesive polyacrylamide nanogel as a potential hydrophobic drug carrier for intravesical bladder cancer therapy. Eur J Pharm Sci. 2015;72:57-68.

14.   Zhang Q, Neoh KG, Xu LQ, Lu SJ, Kang ET, Mahendran R, et al. Functionalized mesoporous silica nanoparticles with mucoadhesive and sustained drug release properties for potential bladder cancer therapy. Langmuir. 2014;30:6151-61.

15.   Lu SJ, Neoh KG, Huang C, Shi ZL, Kang ET. Polyacrylamide hybrid nanogels for targeted cancer chemotherapy via co-delivery of gold nanoparticles and MTX. J Colloid Interf Sci. 2013;412:46-55.

16.   Cai T, Wang R, Yang WJ, Lu SJ, Neoh KG, Kang ET. Multi-functionalization of poly(vinylidene fluoride) membranes via combined "grafting from" and "grafting to" approaches. Soft Matter. 2011;7:11133-43.