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Clin Assoc Prof Yap Jiunn Liang Jonathan

Dr Jonathan Yap from National Heart Centre Singapore

Clin Assoc Prof Yap Jiunn Liang Jonathan

MBBS, MRCP (UK), M Med (Int Med), MPH, FAMS (Cardiology), FACC, FESC, GDip (Pall Med)

Consultant

National Heart Centre Singapore

Specialty: Cardiology

Sub-specialties: Interventional Cardiology, Structural Heart Disease

Clinical Appointments

  • Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore
  • Consultant NHCS Cardiology @ SKH Sengkang General HospitalSengkang General Hospital

Academic Appointments

  • Director, Medical Student Training SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme

Profile

Clinical Associate Professor Jonathan Yap is a Consultant with the Department of Cardiology at NHCS. His subspeciality interest is in interventional cardiology, pulmonary hypertension and structural heart disease including transcatheter aortic valve interventions (TAVI) for aortic stenosis. He spent a year in the United States performing his advanced fellowship in structural heart interventions at UC Davis Health, a high-volume tertiary cardiac centre.

 Clin Assoc Prof Yap has a keen interest in education and research. He is involved in several ongoing research projects and has published extensively in many international scientific journals. He is also the editor of an electrocardiogram (ECG) teaching app.

Education

  • GDip (Pall Med) 2018
  • MPH (S’pore) 2016
  • M Med (Int Med) 2013
  • MRCP (UK) 2013
  • MBBS (Singapore) 2007

Professional Appointments and Committee Memberships

  • Consultant, Department of Cardiology, National Heart Centre Singapore, May 2019 – Present​
  • Consultant, NHCS Cardiology @ SKH, Sengkang General Hospital
  • Director, Medical Student Training, SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme, April 2021 – Present​
  • Fellow, European Society of Cardiology, 2019 – Present
  • Fellow, American College of Cardiology , 2019 – Present
  • Chairman,  BCLS courses, St John’s Association of Singapore, 2014 – Present
  • Core Faculty, SingHealth Cardiology Senior Residency Programme
  • Clinical Associate Professor, Duke-NUS Medical School
  • Clinical Senior Lecturer, YLL school of Medicine, NUS
  • Teaching faculty, LKC School of Medicine, NTU
  • Member, Royal College of Physicians (UK), 2013 – Present
  • Council member, Singapore Cardiac Society, 2017 – 2018
  • Council member, Chapter of Cardiology, 2017 – 2019

Awards

  • SingHealth Quality Service Award (Star) 2019 
  • SingHealth Quality Service Award (Gold) 2018
  • SingHealth Quality Service Award (Silver) 2017
  • Singapore Cardiac Society Best Oral Presentation (Free paper session) 2016
  • RiSE Award 2016 (Commendation for Outstanding Residents)
  • RiSE Award 2015 (Commendation for Outstanding Residents)
  • Outstanding Chief Resident Award 2015
  • NUS YLL SoM Special Recognition Award 2015 (Award for being a role model for graduating class 2015)
  • Residents’ Committee Appreciation Award 2015
  • RiSE Award 2014(Commendation for Outstanding Residents)
  • RiSE Award 2013 (Commendation for Outstanding Residents)
  • SGH Annual Scientific Meeting Best Poster Award 2013
  • Outstanding performance at In-training Exam Award 2013
  • AM•EI Aspiring Educator Award 2013 (Award for outstanding contributions towards medical education)
  • Outstanding Young Educator Award 2013 (Award for active contributions towards medical education)
  • Singhealth Best Resident Award 2013 (Award for top-performing residents) 
  • Singhealth Best Resident Award 2012 (Award for top-performing residents)
  • Singapore Cardiac Society Young Investigator’s Award 2012 (2nd prize)

Research Interests

  • Deep learning, artificial intelligence
  • Medical technology
  • Registry research
  • Structural heart disease

Publications

Book Chapters

  • Overview of Equipment and Procedure. Chapter 1. Yap J, Yeo KK, Teo T, Low R. Clinical Cases in Rotational Atherectomy. Springer 2017
  • Complex Case: Rotational Atherectomy in Myocardial Infarction. Chapter 15. Yap J, Tan JWC. Clinical Cases in Rotational Atherectomy. Springer 2017
  • Complication: Sheared Wire Clinical Cases in Rotational Atherectomy. Chapter 23. Yap J, Tan JWC. Springer 2017
  • Complication: Dislodged Burr. Chapter 24. Yap J, Yeo KK. Clinical Cases in Rotational Atherectomy. Springer 2017

Applications

  • Dr ECG. Yap J, Ching CK, Tan BY. An interactive ECG teaching app available on App store and Google Play.


Publications

  • Myocardial compressibility: Debunking an age-old paradigm to discriminate diseased from normal myocardium. Tay JCK, Yap J*. Int J Cardiol 2021;322:284-285.
    *last and corresponding author
  • Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure. Tan ESJ, Chan SP, Liew OW, Chong JPC, Leong GKT, Yeo DPS, Ong HY, Jaufeerally F, Yap J, et al. Clin Chem 2021;67:216-226. 
  • Technical considerations for repeat TAVI in the failing Direct Flow transcatheter heart valve. Yap J, Southard JA, Wong GB, Singh GD, Stripe BR. EuroIntervention 2020; EIJ-D-20-00426. 
  • Technical considerations for TAVR in the treatment of stentless bioprosthetic aortic valve insufficiency in LVAD patients. Yap J, Stripe BR, Wong GB, et al. J Invasive Cardiol 2020;32:E174 
  • Transjugular mitral valve repair with the MitraClip: A step-by-step guide. Yap J, Chen S, Smith TWR, Rogers JH, Singh GD. Catheter Cardiovasc Interv. 2020
  • Transseptal access for left heart structural interventions in the setting of prior atrial septal defect closure. Yap J, Chen S, Stripe BR, et al. Catheter Cardiovasc Interv. 2020;95:414-419. 
  • Impact of Chronic Kidney Disease on Outcomes in Transcatheter Aortic Valve Implanatation. Yap J, Tay JCK, Ewe SH, et al. Ann Acad Med Singapore. 2020;49:273-84
  • Clinical Updates on Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension. Ruan W, Yap J*, Quah KH, et al. Ann Acad Med Singapore. 2020;49:320-30*co-first author
  • QRS duration and cardiovascular mortality in Asian patients with heart failure and preserved and reduced ejection fraction. Yap J, Keh YS, Shen T, et al. Cardiol J. 2020 
  • Risk Stratification in Heart Failure: Existing Challenges and Potential Promise. Yap J. Int J Cardiol 2020; S0167-5273(20)31672-7
  • Impact of myocardial viability assessed by cardiac magnetic resonance on survival in patients with severe left ventricular dysfunction. Yap J, Lim FY, Gao F, et al. Circ Reports 2020 
  • Elderly Asian Patients Have Lower Revascularisation Rates and Poorer Outcomes for ST-Elevation Myocardial Infarction Compared to Younger Patients. Cai JX, Yap J, Gao F, et al. Ann Acad Med Singapore. 2020
  • Adjunctive use of fluoroscopy during MitraClip implantation reduces procedural complexity: The parallax technique. Singh GD, Rogers JH, Chen S, Yap J, et al. Catheter Cardiovasc Interv 2020
  • Five-Meter Walk Test as a Predictor of Prolonged Index Hospitalization After Transcatheter Aortic Valve Implantation. Koh JQS, Mohamed Rahim NB, Sng EL, Yap J, et al. Am J Cardiol 2020;132:100-105. 
  • Elevated Right Atrial Pressure Associated with Alteration of Left Ventricular Contractility and Ventricular-Arterial Coupling in Pulmonary Artery Hypertension. Zhao X, Zhang JM, Bryant JA, Yap J, et al. Conf Proc IEEE Eng Med Biol Soc. 2019:820-823.
  • A randomized controlled trial on the effectiveness of a portable patient education video prior to coronary angiography and angioplasty. Yap J, Teo TY, Foong P, et al. Catheter Cardiovasc Interv. 2019 
  • Harnessing technology and molecular analysis to understand the development of cardiovascular diseases in Asia: a prospective cohort study (SingHEART). Yap J, Lim WK, Sahlén A, et al. BMC Cardiovasc Disord. 2019;19:259. 
  • Association of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction. Yap J, Tay WT, Teng TK, et al. J AM Heart Assoc 2019
  • Particulate air pollution on cardiovascular mortality in the tropics: impact on the elderly. Yap J, Ng Y, Yeo KK, et al. Environ Health 2019
  • The Singapore Heart Failure Risk Score: Prediction of Survival in Southeast Asian Patients. Yap J, Chia SY, Lim FY, et al. Ann Acad Med Singapore 2019;48:86-94
  • Prediction of Survival in Asian Patients Hospitalized With Heart Failure: Validation of the OPTIMIZE-HF Risk Score. Yap J, Lim FY, Chia SY, et al. J Card Fail 2019; pii: S1071-9164
  • Can Lightning Strike Twice? Tackling Complications From Transcatheter Aortic Valve Implantation. Yap J, Ewe SH, Chao V, Ho KW. J Invasive Cardiol 2019;31:e271
  • Outcomes of primary percutaneous coronary intervention in acute myocardial infarction due to unprotected left main thrombosis: The Asia-Pacific left main ST-Elevation Registry (ASTER). Yap J, Singh GD, Kim JS, et al. J Interven Cardiol 2018;31:129-135
  • Pulmonary Endarterectomy in South-east Asia. Yap J, Chao V, Lim ST, et al. J Thorac Cardiovasc Surg 2019;157:e183
  • Is Subdural Hemorrhage after Pulmonary Endarterectomy Under-recognised? Yap J, Ruan W, Chia A, et al. J Thorac Cardiovasc Surg 2018;156:2039-2042
  • Multi-ethnic comparisons of diabetes in heart failure with reduced ejection fraction: insights from the HF-ACTION trial and the ASIAN-HF registry. Cooper LB, Yap J*, Tay WT, et al. Eur J Heart Fail 2018;20:1281-1289
    *co-first author
  • Correlation of the New York Heart Association classification and the cardiopulmonary exercise test: A systematic review. Lim FY, Yap J*, Gao F, Teo LL, Lam CSP, Yeo KK. Int J Cardiol 2018;263:88-93.
    *co-first author
  • Management of anti-thrombotic therapy in patients with recent percutaneous coronary intervention and acute dengue infection: A case series. Aditya W, Yap J, Chlebicki P, et al. Proc of Sing Healthcare 2019.
    *co-first author
  • Attitudes and perspectives of patients toward medical trainees. Yap J, Thiagarajan N, Shen T, et al. Proc of Sing Healthcare 2018
  • Erectile dysfunction: A hidden epidemic. Yap J, Tan FCL, Shen T, et al. Proc of Sing Healthcare 2018
  • Management of patients with diabetes and heart failure with reduced ejection fraction: an international comparison. Arnold SV, Yap J, Lam CSP, et al. Diabetes Obes Metab 2019;21:261-2662018 
  • Triaging Primary Care Patients Referred for Chest Pain to Specialist Cardiology Centres: Efficacy of an Optimised Protocol. Tan FC, Yap J, Allen JC, et al. Ann Acad Med Singapore. 2018;47:56-62
  • Influenza-Associated Hospitalizations for Cardiovascular Diseases in the Tropics. Ang LW, Yap J*, Lee V, et al. Am J Epidemiol 2017;186:202-209
    *co-first author
  • Impact of stock market volatility on mortality and cardiovascular events. Yap J, Earnest A, Lee V, Sng G, Lam C, Yeo KK. Int J Cardiol 2016;223:318-319. 
  • Longitudinal Community-Based Study of QT Interval and Mortality in Southeast Asians. Yap J, Jin AZ, Nyunt SZ, et al. PLoS One 2016
  • Predictors of Two-year Mortality in Asian Patients with Heart Failure and Preserved Ejection Fraction. Yap J, Sim D, Lim CP, et al. Int J Cardiol 2015;183:33-8
  • Correlation of the New York Heart Association Classification and the 6-Minute Walk Distance: A Systematic Review. Yap J, Lim FY, Gao F, et al. Clin Cardiol 2015;38:621-8
  • Assessment of left ventricular preload by cardiac magnetic resonance imaging predicts exercise capacity in adult operated tetralogy of Fallot: a retrospective study. Yap J, Tan JL, Le TT, et al. BMC Cardiovasc Disord. 2014;14:122. 
  • Complementary and alternative medicine use amongst patients with cardiovascular disease in Singapore. Teo TY, Yap J*, Shen T, Yeo KK. BMC Complement Altern Med 2016;16:446.
    *co-first author
  • Myocardial viability in ischemic left ventricular dysfunction. Yap J, Tan RS. N Engl J Med 2011;365:472
  • Oseltamivir ring prophylaxis for containment of Influenza A (H1N1-2009) Outbreaks. Lee VJ, Yap J, Cook A, et al. N Engl J Med 2010;362:2166-74
  • Clinical Outcomes of Bioresrobable Scaffold in Coronary Artery Disease: A Systematic Literature Review. Keh YS, Yap J*, Yeo KK, et al. J Interv Cardiol 2016;29:57-69
    *co-first author
  • Association of Age, Sex, Body Size and Ethnicity with ECG Values in Community-Based Older Asian Adults. Tan ES, Yap J*, Xu CF, et al. Heat Lung Circ 2016;25:705-11
    *co-first author
  • Venous Access Closure Using the Double-ProGlide Preclose Technique After MitraClip Implantation: Long-Term Clinical and Duplex Ultrasound Outcomes. Yeo KK, Yap J, Tan JW, et al. J Invasive Cardiol 2016;28:40-3
  • Percutaneous mitral valve repair with the MitraClip: early results from the MitraClip Asia-Pacific Registry (MARS). Yeo KK, Yap J, Yamen E, et al. EuroIntervention 2014;10:620-5
  • Fragmented QRS complexes predict right ventricular dysfunction and outflow tract aneurysms in patients with repaired tetralogy of Fallot. Shanmugam N*, Yap J*, Tan RS, et al. Int J Cardiol 2012
    *co-first author
  • The MitraClip Asia-Pacific registry: Differences in outcomes between functional and degenerative mitral regurgitation. Tay E, Muda N, Yap J, et al. Catheter Cardiovasc Interv. 2015
  • Gender Differences in Knowledge, Attitudes and Practices towards Cardiovascular Disease and its Treatment among Asian Patients. Shen T, Teo TY, Yap J, Yeo KK. Ann Acad Med Singapore. 2017;46:20-28.
  • Ethnic differences in atrial fibrillation among patients with heart failure in Asia. Tan ESJ, Goh V, Santema BT, Tay WT, Teng TK, Yap J, et al. ESC Heart Fail. 2020 
  • E/e' in relation to outcomes in ST-elevation myocardial infarction. Tai SB, Lau WR, Gao F, Hamid N, Amanullah MR, Fam JM, Yap J, et al. Echocardiography. 2020 
  • Regional Variation of Mortality in Heart Failure With Reduced and Preserved Ejection Fraction Across Asia: Outcomes in the ASIAN-HF Registry. MacDonald MR, Tay WT, Teng TK, Anand I, Ling LH, Yap J, et al. J Am Heart Assoc. 2020;9:e012199. 
  • Building a Longitudinal National Integrated Cardiovascular Database―Lessons Learnt From SingCLOUD― Yeo KK, Ong HY, Chua T, Lim ZJ, Yap J, et al. Circ Reports 2020
  • Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. Teo JX, Davila S, Yang C, Hii AA, Pua CJ, Yap J, et al. Commun Biol. 2019;2:361. 
  • Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study. Chandramouli C, Tay WT, Bamadhaj NS, Tromp J, Teng TK, Yap J, et al. PLoS Med. 2019;16:e1002916.
  • Mortality and hospitalization outcomes of interstitial lung disease and pulmonary hypertension in the Singapore systemic sclerosis cohort. Noviani M, Saffari SE, Tan JL, Yip JWL, Teng GG, Law WG, Chan GYL, Santosa A, Lim AYN, Hong C, Ng SA, Tay ELW, Ruan W, Yap J, Low AHL. Semin Arthritis Rheum. 2019 
  • Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction. Tromp J, Lim SL, Tay WT, Teng TK, Chandramouli C, Ouwerkerk W, Wander GS, Sawhney JPS, Yap J, et al. Diabetes Care 2019;42:1792-1799. 
  • Cornell product is an ECG marker of heart failure with preserved ejection fraction. Tan ES, Chan SP, Xu CF, Yap J, et al. Heart Asia 2019;11:e011108
  • Prescription patterns of anti-diabetic medications and clinical outcomes in Asian patients with heart failure and diabetes mellitus. Chia YMF, Teng TK, Tay WT, Anand I, MacDonald MR, Yap J, et al. Eur J Heart Fail. 2019;21:685-688
  • Defining a 'frequent admitter' phenotype among patients with repeat heart failure admissions. Go YY, Sellmair R, Allen JC Jr, Sahlén A, Bulluck H, Sim D, Jaufeerally FR, MacDonald MR, Lim ZY, Chai P, Loh SY, Yap J, Lam CSP. Eur J Heart Fail 2019;21:311-318.
  • Heart failure with preserved ejection fraction in Asia. Tromp J, Teng TH, Tay WT, Hung CL, Narasimhan C, Shimizu W, Park SW, Liew HB, Ngarmukos T, Reyes EB, Siswanto BB, Yu CM, Zhang S, Yap J, et al. Eur J Heart Fail 2019;21:23-36
  • Air pollution in relation to very short-term risk of ST-segment elevation myocardial infarction: Case-crossover analysis of SWEDEHEART. Sahlén A, Ljungman P, Erlinge D, Chan MY, Yap J, et al. Int J Cardiol 2019;275:26-30.
  • Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry. Chandramouli C, Teng TK, Tay WT, Yap J, et al. Eur J Heart Fail 2019;21:297-307.
  • Heart Failure With Preserved Ejection Fraction in the Young. Tromp J, MacDonald MR, Tay WT, Teng TK, Hung CL, Narasimhan C, Shimizu W, Ling LH, Ng TP, Yap J, et al. Circulation 2018;138:2763-2773
  • Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: a cohort study. Teng TK, Tromp J, Tay WT, Anand I, Ouwerkerk W, Chopra V, Wander GS, Yap J, et al. Lancet Glob Health 2018;6:e1008-e1018. 
  • Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research. Lim WK, Davila S, Teo JX, Yang C, Pua CJ, Blöcker C, Lim JQ, Ching J, Yap J, et al. PLoS Biol. 2018;16:e2004285.
  • Prevalence, clinical correlates, and outcomes of anaemia in multi-ethnic Asian patients with heart failure with reduced ejection fraction. Goh VJ, Tromp J, Teng TK, Tay WT, Van Der Meer P, Ling LH, Siswanto BB, Hung CL, Shimizu W, Zhang S, Narasimhan C, Yu CM, Park SW, Ngarmukos T, Liew HB, Reyes E, Yap J, et al. ESC Heart Fail. 2018;5:570-578. 
  • Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry. Tromp J, Tay WT, Ouwerkerk W, Teng TK, Yap J, et al. PLoS Med. 2018;15:e1002541.
  • Clinical correlates and pharmacological management of Asian patients with concomitant diabetes mellitus and heart failure. Chia YMF, Teng TK, Chandramouli C, Yap J, MacDonald M, Lam CSP. Heart Fail Rev 2018; 23:461-46
  • Advanced analyses of computed tomography coronary angiography can help discriminate ischemic lesions. Zhang JM, Shuang D, Baskaran L, Wu W, Teo SK, Huang W, Gobeawan L, Allen JC, Tan RS, Su X, Ismail NB, Wan M, Su B, Zou H, Low R, Zhao X, Chi Y, Zhou J, Su Y, Lomarda AM, Chin CY, Fam JM, Keng FYJ, Wong ASL, Tan JWC, Yeo KK, Wong PEH, Chin CT, Ho KW, Yap J, et al. Int J Cardiol 2018 Sep 15;267:208-214
  • Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure. Luo N, Teng TK, Tay WT, Anand IS, Kraus WE, Liew HB, Ling LH, O'Connor CM, Piña IL, Richards AM, Shimizu W, Whellan DJ, Yap J, Lam CSP, Mentz RJ. Am Heart J. 2017;191:75-81.
  • Disparity Between Indications for and Utilization of Implantable Cardioverter Defibrillators in Asian Patients With Heart Failure. Chia YMF, Teng TK, Tan ESJ, Tay WT, Richards AM, Chin CWL, Shimizu W, Park SW, Hung CL, Ling LH, Ngarmukos T, Omar R, Siswanto BB, Narasimhan C, Reyes EB, Yu CM, Anand I, MacDonald MR, Yap J, Zhang S, Finkelstein EA, Lam CSP. Circ Cardiovasc Qual Outcomes. 2017;10: pii: e003651.
  • Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry. Lam CS, Teng TK, Tay WT, Anand I, Zhang S, Shimizu W, Narasimhan C, Park SW, Yu CM, Ngarmukos T, Omar R, Reyes EB, Siswanto BB, Hung CL, Ling LH, Yap J, et al. Eur Heart J. 2016;37:3141-3153.
  • Racial Differences in ECG Characetristics and Prognostic Significance in Whites Versus Asians dictors of Two-year Mortality in Asian Patients with Heart Failure and Preserved Ejection Fraction. Santhanakrishnan R, Wang N, Larson MG, Magnani JM, Vasan RS, Wang TJ, Yap J, et al. J Am Heart Assoc 2016
  • Simplified Models of Non-Invasive Fractional Flow Reserve Based on CT Images. Zhang JM, Zhong L, Luo T, Lomarda AM, Huo Y, Yap J, et al. PLoS One 2016
  • Understanding arrhythmogenic right ventricular cardiomyopathy: Use of patient-specific induced pluripotent stem cell models. Yap J, Liew R. Journal of Arrhythmia 2014
  • Predictors of mortality in acute heart failure: interaction between diabetes and impaired left ventricular ejection fraction. Go YY, Allen JC, Chia SY, Sim LL, Jaufeerally FR, Yap J, et al. Eur J Heart Fail 2014 
  • An unusual presentation of aortic saddle embolus. Yap J, Chua YL, Wong A. Heart Asia 2014;6:10
  • Atrial septostomy in a patient with severe pulmonary hypertension and hypoxia: A therapeutic dilemma. Yap J, Yeo KK, Tan JL, Lim ST. Asean Heart J 2014;21:6
  • An unusal case of complete heart block. Yap J, Chua YL, Liew R. Eur Heart J Cardiovasc Imaging 2013;14:87
  • Catheter ablation of VF storm in a long QT syndrome genotype carrier with normal QT interval. Yap J, Tan VH, Hsu LF, et al. Singapore Med J 2013;54:e1-4
  • Catheter ablation of ventricular fibrillation triggers and electrical storm. Tan VH, Yap J, Hsu LF, et al. Europace 2012;14:1687-95
  • Current and emerging therapies for stroke prophylaxis in atrial fibrillation. Lim TSE, Yap J, Chin CT. Clin Inv 2011;1:1019-37
  • Effectiveness of external topical medications in the treatment of keloid scars: a review. Wang S, Yap J. Hong Kong J Dermatol Venereol 2016:24:120-128
  • An unusual presentation of Listeriosis: Anemia and cutaneous manifestations. Teo HK*, Yap J*, Fong YT. SEA Journal of Trop Med and Public Health 2014
    *co-first & corresponding author
  • Differing clinical characteristics between influenza strains among young adults in the tropics. Yap J, Tan CH, Cook AR, et al. BMC Infect Dis 2012;12:12
  • Outbreak of Acute Norovirus Gastroenteritis on a Military Facility in Singapore: A Public Health Perspective. Yap J, Qadir A, Liu I et al. Singapore Med J 2012;53:249-54
  • Investigation of Causes of Oseltamivir Chemoprophylaxis Failures during Influenza A (H1N1-2009) outbreaks. Lee VJ, Yap J, Maurer-Stroh S, et al. J Clin Virol 2011;50:104-8
  • A clinical diagnostic model for predicting influenza among young adult military personnel with febrile respiratory illness in Singapore. Lee VJ, Yap J, Cook AR, et al. PLoS One 2011;6:e17468
  • Comparability of different methods for estimating influenza infection rates over a single epidemic wave. Lee VJ, Chen MI, Yap J, et al. Am J Epidemiol 2011;174:468-78
  • Effectiveness of pandemic H1N1-2009 vaccination in reducing laboratory confirmed influenza infections among military recruits in tropical Singapore. Lee VJ, Tan CH, Yap J et a.l. PLoS One 2011;6(10):e26572.
  • 2009 Influenza A(H1N1) seroconversion rates and risk factors among distinct adult cohorts in Singapore. Chen MI, Lee VJ, Lim WY, Barr I, Lin RTP, Koh GCH, Yap J, et al. JAMA 2010;303:1383-91
  • Knowledge, Attitudes and Practices towards Pandemic Influenza among Cases, Close Contacts, and Healthcare Workers in Tropical Singapore: A Cross-sectional Survey. Yap J, Lee VJ, Yau TY, et al. BMC Public Health 2010;10:442
  • Effectiveness of public health measures in mitigating pandemic influenza spread: A prospective sero-epidemiological cohort study. Lee VJ, Yap J, Cook A, et al. J Infect Dis 2010;202:1319-26  
  • Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009. Lee VJ, Yap J, Tay JK, et al. BMC Infect Dis 2010;10:164
  • Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains. Lee VJ, Tay JK, Chen MI, Phoon MC, Xie ML, Wu Y, Lee CX, Yap J, et al. Vaccine 2010;28:6852-7 
  • Serological response in RT-PCR confirmed H1N1-2009 influenza A by hemagglutination inhibition and virus neutralization assays: an observational study. Chen MI, Barr IG, Koh GC, Lee VJ, Lee CP, Shaw R, Cui L, Yap J, et al. PLoS One 2010;5:e12474
  • Influenza excess mortality from 1950-2000 in tropical Singapore. Lee VJ, Yap J, Ong J, et al. PLoS One 2009;4:e8096 

Research Trials

​Clin Assoc Prof Yap is currently involved in numerous research trials.