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Clin Assoc Prof Tan Ru San

Adj Assoc Prof Tan Ru San from National Heart Centre Singapore

Clin Assoc Prof Tan Ru San

MBBS, MRCP(UK)(Int Med), FAMS

Senior Consultant

National Heart Centre Singapore

Specialty: Cardiology

Sub-specialties: Nuclear Imaging, Echocardiography

Conditions Treated by this Doctor:
General Cardiology.

Clinical Appointments

  • Senior Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore

Academic Appointments

  • Research EXCO SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme

Profile

Clinical Associate Professor Tan Ru San is a Senior Consultant with the Department of Cardiology at the National Heart Centre Singapore. He is also in the Research EXCO for the SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme.

He has founded a team of scientists and engineers that focuses research on cardiac imaging, cardiac mechanics, engineering and physiology using advanced computational models, including computational fluid dynamics, finite element analyses and artificial intelligence.

Clin Assoc Prof Tan is also an experienced clinical trialist, and has been a member on the steering committees of several multinational landmark clinical trials.

Education

  • Fellowship at Royal Brompton Hospital, UK 2000
  • MRCP (UK) 1996 
  • MBBS National University of Singapore 1991 

Professional Appointments and Committee Memberships

  • Research Executive Committee Member, SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme
  • Fellow, Academy of Medicine, 2002
  • Member, Royal College of Physicians (United Kingdom), 1996
  • Clinical Trials Research Office Steering Committee Member, National Heart Centre Singapore
  • Academic Medicine Grant Review Committee Member, SingHealth Office of Research
  • Clinician Scientist/Clinician Investigator Salary Support Programme Review Committee Member, SingHealth Office of Research

Awards

Research Interests

  • Cardiac imaging
  • Cardiac bioengineering
  • Artificial intelligence applications in medicine
  • Clinical trials

Publications

Publications

  • Rajput JS, Sharma M, Tan RS, Acharya UR. Automated detection of severity of hypertension ECG signals using an optimal bi-orthogonal wavelet filter bank. Comput Biol Med. 2020 Aug;123:103924. doi: 10.1016/j.compbiomed.2020.103924. Epub 2020 Jul 23.
  • Li JJ, Liu HH, Wu NQ, Yeo KK, Tan K, Ako J, Krittayaphong R, Tan RS, Aylward PE, Baek SH, Dalal J, Fong AYY, Li YH, O'Brien RC, Lim TSE, Koh SYN, Scherer DJ, Tada H, Kang V, Butters J, Nicholls SJ. Statin intolerance: an updated, narrative review mainly focusing on muscle adverse effects. Expert Opin Drug Metab Toxicol. 2020 Aug 11:1-15. doi: 10.1080/17425255.2020.1802426. Online ahead of print.
  • Zhang JM, Chandola G, Tan RS, Chai P, Teo LLS, Low R, Allen JC, Huang W, Fam JM, Chin CY, Wong ASL, Low AF, Kassab GS, Chua T, Tan SY, Lim ST, Zhong L. Quantification of effects of mean blood pressure and left ventricular mass on noninvasive fast fractional flow reserve. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H360-H369. doi: 10.1152/ajpheart.00135.2020. Epub 2020 Jul 17.
  • Friede KA, Infeld MM, Tan RS, Knickerbocker HJ, Myers RA, Dubois LG, Thompson JW, Kaddurah-Daouk R, Ginsburg GS, Ortel TL, Voora D. Influence of Sex on Platelet Reactivity in Response to Aspirin. J Am Heart Assoc. 2020 Jul 21;9(14):e014726. doi: 10.1161/JAHA.119.014726. Epub 2020 Jul 11.
  • Oh SL, Jahmunah V, Ooi CP, Tan RS, Ciaccio EJ, Yamakawa T, Tanabe M, Kobayashi M, Rajendra Acharya U. Classification of heart sound signals using a novel deep WaveNet model. Comput Methods Programs Biomed. 2020 Jun 12;196:105604. doi: 10.1016/j.cmpb.2020.105604. Online ahead of print.
  • Leng S, Ge H, He J, Kong L, Yang Y, Yan F, Xiu J, Shan P, Zhao S, Tan RS, Zhao X, Koh AS, Allen JC, Hausenloy DJ, Mintz GS, Zhong L, Pu J. Long-term Prognostic Value of Cardiac MRI Left Atrial Strain in ST-Segment Elevation Myocardial Infarction. Radiology. 2020 Jun 16:200176.
  • Zhao X, Teo SK, Zhong L, Leng S, Zhang JM, Low R, Allen J, Koh AS, Su Y, Tan RS. Reference Ranges for Left Ventricular Curvedness and Curvedness-Based Functional Indices Using Cardiovascular Magnetic Resonance in Healthy Asian Subjects. Sci Rep. 2020 May 21;10(1):8465.
  • Tao Z, Loo S, Su L, Abdurrachim D, Lalic J, Lee TH, Chen X, Tan RS, Zhang J, Ye L. Dexamethasone inhibits regeneration and causes ventricular aneurysm in the neonatal porcine heart after myocardial infarction. J Mol Cell Cardiol. 2020 May 5;144:15-23.
  • Doenst T, Haddad H, Stebbins A, Hill JA, Velazquez EJ, Lee KL, Rouleau JL, Sopko G, Farsky PS, Al-Khalidi HR; Working Group and Surgical Treatment for IsChemic Heart failure Trial Investigators. Renal function and coronary bypass surgery in patients with ischemic heart failure. J Thorac Cardiovasc Surg. 2020 Apr 3:S0022-5223(20)30742-X.
  • Sim HW, Ngiam NJ, Zhong L, Tan BY, Low LY, Djohan AH, Boey E, Kong WKF, Tan RS, Poh KK. A new non-invasive index for prognosis evaluation in patients with aortic stenosis. Sci Rep. 2020 Apr 30;10(1):7333.
  • Leong WYA, Ngiam JN, Tan RS, Lim SL, Poh KK. Controversies and discrepancies in the effect of dietary fat and cholesterol on cardiovascular risk. Singapore Med J. 2020 Apr 21. doi: 10.11622/smedj.2020065.
  • Soh DCK, Ng EYK, Jahmunah V, Oh SL, San TR, Acharya UR. A computational intelligence tool for the detection of hypertension using empirical mode decomposition. Comput Biol Med. 2020 Mar;118:103630.
  • Lih OS, Jahmunah V, San TR, Ciaccio EJ, Yamakawa T, Tanabe M, Kobayashi M, Faust O, Acharya UR. Comprehensive electrocardiographic diagnosis based on deep learning. Artif Intell Med. 2020 Mar;103:101789.
  • Leng S, Tan RS, Zhao X, Allen JC, Koh AS, Zhong L. Fast long-axis strain: a simple, automatic approach for assessing left ventricular longitudinal function with cine cardiovascular magnetic resonance. Eur Radiol. 2020 Feb 27.
  • Wan M, Ma L, Zhao X, Leng S, Zhang JM, Tan RS, Zhong L. Automatic Segmentation of Coronary Artery Lumen via Anisotropic Graph-cuts. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:4871-4874.
  • Yang X, Su Y, Tjio G, Yang F, Ding J, Kumar S, Leng S, Zhao X, Tan RS, Zhong L. A Multi-channel Deep Learning Approach for Segmentation of the Left Ventricular Endocardium from Cardiac Images. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:4016-4019.
  • Zhao X, Zhang JM, Bryant JA, Yap J, Ong CC, Singh D, Lim ST, Yip JW, Chen Y, Zhong L, Tan RS, Tan JL, Chai P, Teo L, Fortier MV, Hong Tan T, Leng S, Ruan W. Elevated Right Atrial Pressure Associated with Alteration of Left Ventricular Contractility and Ventricular-Arterial Coupling in Pulmonary Artery Hypertension. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:820-823.
  • Butun E, Yildirim O, Talo M, Tan RS, Rajendra Acharya U. 1D-CADCapsNet: One dimensional deep capsule networks for coronary artery disease detection using ECG signals. Phys Med. 2020 Jan 18;70:39-48.Zou H, Leng S, Xi C, Zhao X, Koh AS, Gao F, Tan JL, Tan RS, Allen JC, Lee LC, Genet M, Zhong L. Three-dimensional biventricular strains in pulmonary arterial hypertension patients using hyperelastic warping. Comput Methods Programs Biomed. 2020 Jan 17;189:105345.
  • Shen X, Tan BYQ, Sia CH, Lee JSW, Dalakoti M, Wang K, Lim DYZ, Sng GGR, Lee ECY, Chow W, Kwan CKW, Wang LK, Tan BY, Lim PCY, Chua KCM, Ho KL, Lim ETS, Ching CK, Teo WS, Chua TSJ, Tan RS, Yeo TJ, Chong DTT. Prevalence of Brugada Syndrome in a large population of young Singaporean men. Circulation. 2020 Jan 14;141:155-157.
  • Keng BMH, Gao F, Teo LLY, Lim WS, Tan RS, Ruan W, Ewe SH, Koh WP, Koh AS. Associations between skeletal muscle and myocardium in aging: a syndrome of "cardio-sarcopenia"? J Am Geriatr Soc. 2019;67:2568-2573.
  • Sharma M, Singh S, Kumar A, San Tan R, Acharya UR. Automated detection of shockable and non-shockable arrhythmia using novel wavelet-based ECG features. Comput Biol Med. 2019;115:103446.
  • Abdar M, Książek W, Acharya UR, Tan RS, Makarenkov V, Pławiak P. A new machine learning technique for an accurate diagnosis of coronary artery disease. Comput Methods Programs Biomed. 2019;179:104992.
  • Panza JA, Ellis AM, Al-Khalidi HR, Holly TA, Berman DS, Oh JK, Pohost GM, Sopko G, Chrzanowski L, Mark DB, Kukulski T, Favaloro LE, Maurer G, Farsky PS, Tan RS, Asch FM, Velazquez EJ, Rouleau JL, Lee KL, Bonow RO. Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy. N Engl J Med. 2019;381:739-748.
  • Keng BMH, Gao F, Ewe SH, Tan RS, Teo LLY, Xie BQ, Koh WP, Koh AS. Galectin-3 as a candidate upstream biomarker for quantifying risks of myocardial ageing. ESC Heart Fail. 2019;65:1068-1076.
  • Zhong L, Schrauben EM, Garcia J, Uribe S, Grieve SM, Elbaz MSM, Barker AJ, Geiger J, Nordmeyer S, Marsden A, Carlsson M, Tan RS, Garg P, Westenberg JJM, Markl M, Ebbers T. Intracardiac 4D Flow MRI in Congenital Heart Disease: Recommendations on Behalf of the ISMRM Flow & Motion Study Group. J Magn Reson Imaging. 2019;503:677-681.
  • Yildirim O, Baloglu UB, Tan RS, Ciaccio EJ, Acharya UR. A new approach for arrhythmia classification using deep coded features and LSTM networks. Comput Methods Programs Biomed. 2019;176:121-133.
  • Jahmunah V, Oh SL, Wei JKE, Ciaccio EJ, Chua K, San TR, Acharya UR. Computer-aided diagnosis of congestive heart failure using ECG signals – A review. Phys Med. 2019;62:95-104.
  • Acharya UR, Faust O, Ciaccio EJ, Koh JEW, Oh SL, Tan RS, Garan H. Application of nonlinear methods to discriminate fractionated electrograms in paroxysmal versus persistent atrial fibrillation. Comput Methods Programs Biomed. 2019;175:163-178.
  • Leng S, Dong Y, Wu Y, Zhao X, Ruan W, Zhang G, Allen JC, Koh AS, Tan RS, Yip JW, Tan JL, Chen Y, Zhong L. Impaired Cardiovascular Magnetic Resonance-Derived Rapid Semiautomated Right Atrial Longitudinal Strain Is Associated With Decompensated Hemodynamics in Pulmonary Arterial Hypertension. Circ Cardiovasc Imaging. 2019;12:e008582.
  • Bulluck H, Chowdhury N, Lim MX, Allen JC, Bryant JA, Chan MY, Chan MHH, Chin CWL, Ho HH, Lim ST, Tan RS, Tan JW, Wong PE, Yeo KK, Cook SA, Hausenloy DJ. Feasibility to Perform T(2) * Mapping Postcontrast Administration in Reperfused STEMI Patients for the Detection of Intramyocardial Hemorrhage. J Magn Reson Imaging. 2019. doi: 10.1002/jmri.26779.
  • Dong Y, Teo SY, Kang K, Tan M, Ling LH, Yeo PSD, Sim D, Jaufeerally F, Leong KTG, Ong HY, Soon D, Lee S, Loh SY, Tan RS, Chan SP, Richards AM, Lam CSP. Cognitive impairment in Asian patients with heart failure: prevalence, biomarkers, clinical correlates, and outcomes. Eur J Heart Fail. 2019;215:688-690.
  • Sia CH, Dalakoti M, Tan BYQ, Lee ECY, Shen X, Wang K, Lee JS, Arulanandam S, Chow W, Yeo TJ, Yeo KK, Chua TSJ, Tan RS, Lam CSP, Chong DTT. A Population-wide study of electrocardiographic (ECG) norms and the effect of demographic and anthropometric factors on selected ECG characteristics in young, Southeast Asian males-results from the Singapore Armed Forces ECG (SAFE) study. Ann Noninvasive Electrocardiol. 2019;243:e12634.
  • Oh SL, Ng EYK, Tan RS, Acharya UR. Automated beat-wise arrhythmia diagnosis using modified U-net on extended electrocardiographic recordings with heterogeneous arrhythmia types. Comput Biol Med. 2019;105:92-101.
  • Leng S, Zhao X, Koh AS, Zhao L, Allen JC, Tan RS, et al. Age-related changes in four-dimensional CMR-derived atrioventricular junction velocities and displacements: Implications for the identification of altered annular dynamics for ventricular function assessment. Int J Cardiol Heart Vasc. 2019;22:6-12.
  • Abdurrachim D, Teo XQ, Woo CC, Ong SY, Salleh NF, Lalic J, Tan RS, et al. Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized 13-C pyruvate, butyrate, and acetoacetate probes. Diabetes Obes Metab. 2018 Dec 11.
  • Ye L, D'Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, Tee GZ, Pua CJ, Pena EM, Cheng RB, Chen WC, Abdurrachim D, Lalic J, Tan RS, et al. Early Regenerative Capacity in the Porcine Heart. Circulation. 2018;138:2798-2808.
  • Leng S, Tan RS, Zhao X, Allen JC, Koh AS, et al. Validation of a rapid semi-automated method to assess left atrial longitudinal phasic strains on cine cardiovascular magnetic resonance imaging. J Cardiovasc Magn Reson. 2018;20:71.
  • Yıldırım Ö, Pławiak P, Tan RS, Acharya UR. Arrhythmia detection using deep convolutional neural network with long duration ECG signals. Comput Biol Med. 2018;102:411-420.
  • Sharma M, Tan RS, Acharya UR. A novel automated diagnostic system for classification of myocardial infarction ECG signals using an optimal biorthogonal filter bank. Comput Biol Med. 2018;102:341-356.
  • Faust O, Shenfield A, Kareem M, San TR, Fujita H, et al. Automated detection of atrial fibrillation using long short-term memory network with RR interval signals. Comput Biol Med. 2018;102:327-335.
  • Andersson B, She L, Tan RS, Jeemon P, Mokrzycki K, et al. The association between blood pressure and long-term outcomes of patients with ischaemic cardiomyopathy with and without surgical revascularization: an analysis of the STICH trial. Eur Heart J. 2018;39:3464-3471.
  • Shah SJ, Lam CSP, Svedlund S, Saraste A, Hage C, Tan RS, et al. Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF. Eur Heart J. 2018;39:3439-3450.
  • Zhang JM, Shuang D, Baskaran L, Wu W, Teo SK, et al. Advanced analyses of computed tomography coronary angiography can help discriminate ischemic lesions. Int J Cardiol. 2018;267:208-214.
  • Adam M, Oh SL, Sudarshan VK, Koh JE, Hagiwara Y, et al. Automated characterization of cardiovascular diseases using relative wavelet nonlinear features extracted from ECG signals. Comput Methods Programs Biomed. 2018 ;161:133-143.
  • Oh SL, Ng EYK, Tan RS, Acharya UR. Automated diagnosis of arrhythmia using combination of CNN and LSTM techniques with variable length heart beats. Comput Biol Med. 2018 Jun 5;PubMed PMID: 29903630.
  • Koh AS, Gao F, Leng S, Kovalik JP, Zhao X, et al. Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking. Sci Rep. 2018 May 25;8(1):8138. PubMed PMID: 29802321; PubMed Central PMCID: PMC5970174.
  • Zhao X, Tan RS, Tang HC, Teo SK, Su Y, et al. Left Ventricular Wall Stress Is Sensitive Marker of Hypertrophic Cardiomyopathy With Preserved Ejection Fraction. Front Physiol. 2018;9:250. PubMed PMID: 29643812; PubMed Central PMCID: PMC5882847.
  • Tan JH, Hagiwara Y, Pang W, Lim I, Oh SL, et al. Application of stacked convolutional and long short-term memory network for accurate identification of CAD ECG signals. Comput Biol Med. 2018 Mar 1;94:19-26. PubMed PMID: 29358103.
  • Zhang S, Le TT, Kabus S, Su B, Hausenloy DJ, et al. Cardiac magnetic resonance T1 and extracellular volume mapping with motion correction and co-registration based on fast elastic image registration. MAGMA. 2018 Feb;31(1):115-129. PubMed PMID: 29270904; PubMed Central PMCID: PMC5813095.
  • Leng S, Zhang S, Jiang M, Zhao X, Wu R, et al. Imaging 4D morphology and dynamics of mitral annulus in humans using cardiac cine MR feature tracking. Sci Rep. 2018 Jan 8;8(1):81. PubMed PMID: 29311562; PubMed Central PMCID: PMC5758818.
  • Zhao X, Tan RS, Tang HC, Leng S, Zhang JM, et al. Analysis of three-dimensional endocardial and epicardial strains from cardiac magnetic resonance in healthy subjects and patients with hypertrophic cardiomyopathy. Med Biol Eng Comput. 2018 Jan;56(1):159-172. PubMed PMID: 28674779.
  • Koh AS, Gao F, Liu J, Fridianto KT, Ching J, et al. Metabolomic profile of arterial stiffness in aged adults. Diab Vasc Dis Res. 2018 Jan;15(1):74-80. PubMed PMID: 28976207.
  • Gandhi M, Tan RS, Ng R, Choo SP, Chia WK, et al. Comparison of health state values derived from patients and individuals from the general population. Qual Life Res. 2017 Dec;26(12):3353-3363. PubMed PMID: 28808840.
  • Koh AS, Velmurugan B, Gao F, Tan RS, Wong JI, et al. Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatr. 2017 Nov 28;17(1):275. PubMed PMID: 29179674; PubMed Central PMCID: PMC5704352.
  • Cannon CP, Bhatt DL, Oldgren J, Lip GYH, Ellis SG, et al. Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation. N Engl J Med. 2017 Oct 19;377(16):1513-1524. PubMed PMID: 28844193.
  • Acharya UR, Oh SL, Hagiwara Y, Tan JH, Adam M, et al. A deep convolutional neural network model to classify heartbeats. Comput Biol Med. 2017 Oct 1;89:389-396. PubMed PMID: 28869899.
  • Xiao P, Zhao X, Leng S, Tan RS, Wong P, et al. A Software Tool for Heart AVJ Motion Tracking Using Cine Cardiovascular Magnetic Resonance Images. IEEE J Transl Eng Health Med. 2017;5:1900412. PubMed PMID: 29018633; PubMed Central PMCID: PMC5630007.
  • Chi Y, Huang W, Zhou J, Toe KK, Zhang JM, et al. Stenosis detection and quantification on cardiac CTCA using panoramic MIP of coronary arteries. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:4191-4194. PubMed PMID: 29060821.
  • Koh AS, Lye WK, Chia SY, Salunat-Flores J, Sim LL, et al. Long-Term Prognostic Value of Appropriate Myocardial Perfusion Imaging. Am J Cardiol. 2017 Jun 15;119(12):1957-1962. PubMed PMID: 28456317.
  • Tan XW, Zheng Q, Shi L, Gao F, Allen JC Jr, et al. Combined diagnostic performance of coronary computed tomography angiography and computed tomography derived fractional flow reserve for the evaluation of myocardial ischemia: A meta-analysis. Int J Cardiol. 2017 Jun 1;236:100-106. PubMed PMID: 28262348.
  • Sudarshan VK, Acharya UR, Oh SL, Adam M, Tan JH, et al. Automated diagnosis of congestive heart failure using dual tree complex wavelet transform and statistical features extracted from 2s of ECG signals. Comput Biol Med. 2017 Apr 1;83:48-58. PubMed PMID: 28231511.
  • Ang AL, Le TT, Tan RS. HbH Constant Spring disease has lower serum ferritin relative to liver iron concentration (LIC): importance of LIC measurement and potential impact on serum ferritin thresholds for iron chelation. Br J Haematol. 2017 Mar;176(6):986-988. PubMed PMID: 26991009.
  • Wang TD, Tan RS, Lee HY, Ihm SH, Rhee MY, et al. Effects of Sacubitril/Valsartan (LCZ696) on Natriuresis, Diuresis, Blood Pressures, and NT-proBNP in Salt-Sensitive Hypertension. Hypertension. 2017 Jan;69(1):32-41. PubMed PMID: 27849566.
  • Faust O, Acharya UR, Sudarshan VK, Tan RS, Yeong CH, et al. Computer aided diagnosis of Coronary Artery Disease, Myocardial Infarction and carotid atherosclerosis using ultrasound images: A review. Phys Med. 2017 Jan;33:1-15. PubMed PMID: 28010920.
  • Xiao P, Zhao X, Leng S, Tan RS, Wong P, et al. A Software Tool for Heart AVJ Motion Tracking Using Cine Cardiovascular Magnetic Resonance Images. IEEE J Transl Eng Health Med. 2017;5:1900412. PubMed PMID: 29018633; PubMed Central PMCID: PMC5630007.
  • Leng S, Jiang M, Zhao XD, Allen JC, Kassab GS, et al. Three-Dimensional Tricuspid Annular Motion Analysis from Cardiac Magnetic Resonance Feature-Tracking. Ann Biomed Eng. 2016 Dec;44(12):3522-3538. PubMed PMID: 27436293.
  • Wan M, Huang W, Zhang JM, Zhao X, Allen JC, et al. Correcting motion in multiplanar cardiac magnetic resonance images. Biomed Eng Online. 2016 Aug 8;15(1):93. PubMed PMID: 27503101; PubMed Central PMCID: PMC4977636.
  • Zhang JM, Chan CJ, Kang N, Soon JL, Sin KY, et al. Comparison of the Haemodynamic Parameters of Venous and Arterial Coronary Artery Bypass Conduits. Ann Acad Med Singapore. 2016 Aug;45(8):369-72. PubMed PMID: 27683743.
  • Cui H, Wang D, Wan M, Zhang JM, Zhao X, et al. Fast Marching and Runge-Kutta Based Method for Centreline Extraction of Right Coronary Artery in Human Patients. Cardiovasc Eng Technol. 2016 Jun;7(2):159-69. PubMed PMID: 27140197.
  • Koh AS, Gao F, Chin CT, Keng FY, Tan RS, et al. Differential risk reclassification improvement by exercise testing and myocardial perfusion imaging in patients with suspected and known coronary artery disease. J Nucl Cardiol. 2016 Jun;23(3):366-78. PubMed PMID: 26358085.
  • Su B, Tan RS, Tan JL, Guo KWQ, Zhang JM, et al. Cardiac MRI based numerical modeling of left ventricular fluid dynamics with mitral valve incorporated. J Biomech. 2016 May 3;49(7):1199-1205. PubMed PMID: 26993615.
  • Park LP, Chu VH, Peterson G, Skoutelis A, Lejko-Zupa T, et al. Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis. J Am Heart Assoc. 2016 Apr 18;5(4):e003016. PubMed PMID: 27091179; PubMed Central PMCID: PMC4859286.
  • Le TT, Tan RS, De Deyn M, Goh EP, Han Y, et al. Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T. J Cardiovasc Magn Reson. 2016 Apr 12;18:21. PubMed PMID: 27071974; PubMed Central PMCID: PMC4830061.
  • Sudarshan VK, Acharya UR, Ng EY, Tan RS, Chou SM, et al. Data mining framework for identification of myocardial infarction stages in ultrasound: A hybrid feature extraction paradigm (PART 2). Comput Biol Med. 2016 Apr 1;71:241-51. PubMed PMID: 26897481.
  • Sudarshan VK, Acharya UR, Ng EY, Tan RS, Chou SM, et al. An integrated index for automated detection of infarcted myocardium from cross-sectional echocardiograms using texton-based features (Part 1). Comput Biol Med. 2016 Apr 1;71:231-40. PubMed PMID: 26898671.
  • Ruan W, Lim SH, Ding ZP, Sim DK, Gao F, et al. Prevalence, Presentation, and Outcome of Heart Failure with Preserved Ejection Fraction among Patients Presenting with Undifferentiated Dyspnoea to the Emergency Room: A 10-year Analysis from a Tertiary Centre. Ann Acad Med Singapore. 2016 Jan;45(1):18-26. PubMed PMID: 27118225.
  • Zhang JM, Zhong L, Luo T, Lomarda AM, Huo Y, et al. Simplified Models of Non-Invasive Fractional Flow Reserve Based on CT Images. PLoS One. 2016;11(5):e0153070. PubMed PMID: 27187726; PubMed Central PMCID: PMC4871505.
  • Leng S, Zhao XD, Huang FQ, Wong JI, Su BY, et al. Automated quantitative assessment of cardiovascular magnetic resonance-derived atrioventricular junction velocities. Am J Physiol Heart Circ Physiol. 2015 Dec 1;309(11):H1923-35. PubMed PMID: 26408537.
  • Jolicœur EM, Dunning A, Castelvecchio S, Dabrowski R, Waclawiw MA, et al. Importance of angina in patients with coronary disease, heart failure, and left ventricular systolic dysfunction: insights from STICH. J Am Coll Cardiol. 2015 Nov 10;66(19):2092-2100. PubMed PMID: 26541919; NIHMSID: NIHMS734288; PubMed Central PMCID: PMC4655599.
  • Jiayin Zhou, Weimin Huang, Yanling Chi, Yuping Duan, Liang Zhong, et al. Quantification of coronary artery Stenosis by Area Stenosis from cardiac CT angiography. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:695-8. PubMed PMID: 26736357.
  • Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, et al. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2015 Jul 16;373(3):232-42. PubMed PMID: 26052984.
  • Chen CH, Chen MC, Gibbs H, Kwon SU, Lo S, et al. Antithrombotic treatment for stroke prevention in atrial fibrillation: The Asian agenda. Int J Cardiol. 2015 Jul 15;191:244-53. PubMed PMID: 25978611.
  • Leng S, Tan RS, Chai KT, Wang C, Ghista D, et al. The electronic stethoscope. Biomed Eng Online. 2015 Jul 10;14:66. PubMed PMID: 26159433; PubMed Central PMCID: PMC4496820.
  • Vidya KS, Ng EY, Acharya UR, Chou SM, Tan RS, et al. Computer-aided diagnosis of Myocardial Infarction using ultrasound images with DWT, GLCM and HOS methods: A comparative study. Comput Biol Med. 2015 Jul;62:86-93. PubMed PMID: 25912990.
  • MacDonald MR, She L, Doenst T, Binkley PF, Rouleau JL, et al. Clinical characteristics and outcomes of patients with and without diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial. Eur J Heart Fail. 2015 Jul;17(7):725-34. PubMed PMID: 26011509; NIHMSID: NIHMS699666; PubMed Central PMCID: PMC4668269.
  • Teo SK, Vos FJ, Tan RS, Zhong L, Su Y. Regional ejection fraction and regional area strain for left ventricular function assessment in male patients after first-time myocardial infarction. J R Soc Interface. 2015 May 6;12(106)PubMed PMID: 25833249; PubMed Central PMCID: PMC4424703.
  • Teo SK, Vos FJ, Tan RS, Zhong L, Su Y. Regional ejection fraction and regional area strain for left ventricular function assessment in male patients after first-time myocardial infarction. J R Soc Interface. 2015 Apr 6;12(105)PubMed PMID: 25694545; PubMed Central PMCID: PMC4387531.
  • Zhang JM, Luo T, Tan SY, Lomarda AM, Wong AS, et al. Hemodynamic analysis of patient-specific coronary artery tree. Int J Numer Method Biomed Eng. 2015 Apr;31(4):e02708. PubMed PMID: 25630671.
  • Ruan W, Wong AS, Tan SY, Tan RS, Chin CT. Chest Pain, Something is Not Right…Or Left. Ann Acad Med Singapore. 2015 Mar;44(3):114-5. PubMed PMID: 25882240.
  • Chirouze C, Alla F, Fowler VG Jr, Sexton DJ, Corey GR, et al. Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study. Clin Infect Dis. 2015 Mar 1;60(5):741-9. PubMed PMID: 25389255; PubMed Central PMCID: PMC4366581.
  • Huang FQ, Tan RS, Sim D, Le TT, Zhong L. Left ventricular diastolic function assessment using time differences between mitral annular velocities and transmitral inflow velocities in patients with heart failure. Heart Lung Circ. 2015 Mar;24(3):257-63. PubMed PMID: 25445427.
  • Delahaye F, Chu VH, Altclas J, Barsic B, Delahaye A, et al. One-year outcome following biological or mechanical valve replacement for infective endocarditis. Int J Cardiol. 2015 Jan 15;178:117-23. PubMed PMID: 25464234.
  • Roberts AM, Ware JS, Herman DS, Schafer S, Baksi J, et al. Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med. 2015 Jan 14;7(270):270ra6. PubMed PMID: 25589632; NIHMSID: NIHMS714330; PubMed Central PMCID: PMC4560092.
  • Leng S, Zhao X, Tan RS, Zhong L. Novel method for atrioventricular motion assessment from three-dimensional cine magnetic resonance imaging. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:319-22. PubMed PMID: 26736264.
  • Zhao X, Shuang L, Tan RS, Zhong L. Computer-based assessment of ventricular mechanical synchrony from magnetic resonance imaging. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:6536-9. PubMed PMID: 26737790.
  • Wan M, Zhong L, Zhang JM, Zhao X, Tan RS, et al. Automatic localization of mitral valve orifice in three-dimensional left cardiac model. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:6540-3. PubMed PMID: 26737791.
  • Wan M, Huang W, Zhang JM, Zhao X, Tan RS, et al. Variational Reconstruction of Left Cardiac Structure from CMR Images. PLoS One. 2015;10(12):e0145570. PubMed PMID: 26689551; PubMed Central PMCID: PMC4699201.
  • Su B, Kabinejadian F, Phang HQ, Kumar GP, Cui F, et al. Numerical Modeling of Intraventricular Flow during Diastole after Implantation of BMHV. PLoS One. 2015;10(5):e0126315. PubMed PMID: 25961285; PubMed Central PMCID: PMC4427484.
  • Sudarshan V, Acharya UR, Ng EY, Meng CS, Tan RS, et al. Automated Identification of Infarcted Myocardium Tissue Characterization Using Ultrasound Images: A Review. IEEE Rev Biomed Eng. 2015;8:86-97. PubMed PMID: 24803322.
  • Chin CT, Gao F, Keng FY, Shah BR, Koh AS, et al. Single-photon emission computed tomography myocardial perfusion imaging-assessed stress perfusion defect severity is associated with mortality independent of ethnicity in an Asian population. J Nucl Cardiol. 2014 Dec;21(6):1148-57. PubMed PMID: 25164138.
  • Yap J, Tan JL, Le TT, Gao F, Zhong L, et al. Assessment of left ventricular preload by cardiac magnetic resonance imaging predicts exercise capacity in adult operated tetralogy of Fallot: a retrospective study. BMC Cardiovasc Disord. 2014 Sep 23;14:122. PubMed PMID: 25245139; PubMed Central PMCID: PMC4177590.
  • Chin CW, Le TT, Gao F, Ng MX, Chin CY, et al. Assessment of arterial elastance and ventricular-arterial coupling in patients with systemic lupus erythematosus. Int J Cardiol. 2014 Sep 20;176(2):504-5. PubMed PMID: 25062562.
  • Chin CW, Chin CY, Ng MX, Le TT, Huang FQ, et al. Endothelial function is associated with myocardial diastolic function in women with systemic lupus erythematosus. Rheumatol Int. 2014 Sep;34(9):1281-5. PubMed PMID: 24549405.
  • Koh AS, Kok TY, Sim DK, Lath N, Tan RS. Imaging cardiac sarcoidosis by cardiac positron emission tomography (PET): a local experience using a high-fat, low-to-no carbohydrate protocol. Ann Acad Med Singapore. 2014 Jul;43(7):383-5. PubMed PMID: 25142475.
  • Wong KS, Hu DY, Oomman A, Tan RS, Patel MR, et al. Rivaroxaban for stroke prevention in East Asian patients from the ROCKET AF trial. Stroke. 2014 Jun;45(6):1739-47. PubMed PMID: 24763930.
  • Zhang JM, Zhong L, Su B, Wan M, Yap JS, et al. Perspective on CFD studies of coronary artery disease lesions and hemodynamics: a review. Int J Numer Method Biomed Eng. 2014 Jun;30(6):659-80. PubMed PMID: 24459034.
  • Su B, Zhong L, Wang XK, Zhang JM, Tan RS, et al. Numerical simulation of patient-specific left ventricular model with both mitral and aortic valves by FSI approach. Comput Methods Programs Biomed. 2014 Feb;113(2):474-82. PubMed PMID: 24332277.
  • Wan M, Kng TS, Yang X, Zhang JM, Zhao X, et al. Left ventricular regional shape dynamics analysis by three-dimensional cardiac magnetic resonance imaging associated with left ventricular function in first-time myocardial infarction patients. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:5113-6. PubMed PMID: 25571143.
  • Zhong L, Zhao X, Wan M, Zhang JM, Su BY, et al. Characterization and quantification of curvature using independent coordinates method in the human left ventricle by magnetic resonance imaging to identify the morphology subtype of hypertrophy cardiomyopathy. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:5619-22. PubMed PMID: 25571269.
  • Yang X, Su Y, Wan M, Yeo SY, Lim C, et al. Left ventricle segmentation by dynamic shape constrained random walks. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:4723-6. PubMed PMID: 25571047.
  • Zhong L, Wan M, Su Y, Teo SK, Lim CW, et al. Graph-cuts based reconstructing patient specific right ventricle: first human study. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:6770-3. PubMed PMID: 25571550.
  • Zhang JM, Zhong L, Luo T, Huo Y, Tan SY, et al. Numerical simulation and clinical implications of stenosis in coronary blood flow. Biomed Res Int. 2014;2014:514729. PubMed PMID: 24987691; PubMed Central PMCID: PMC4058689.
  • Lim CW, Su Y, Yeo SY, Ng GM, Nguyen VT, et al. Automatic 4D reconstruction of patient-specific cardiac mesh with 1-to-1 vertex correspondence from segmented contours lines. PLoS One. 2014;9(4):e93747. PubMed PMID: 24743555; PubMed Central PMCID: PMC3990569.
  • Zhong L, Zhang JM, Zhao X, Tan RS, Wan M. Automatic localization of the left ventricle from cardiac cine magnetic resonance imaging: a new spectrum-based computer-aided tool. PLoS One. 2014;9(4):e92382. PubMed PMID: 24722328; PubMed Central PMCID: PMC3982962.
  • Zhong L, Huang FQ, Tan LK, Allen JC, Ding ZP, et al. Age and gender-specific changes in left ventricular systolic function in human volunteers. Int J Cardiol. 2014;172(1):e102-5. PubMed PMID: 24438932.
  • Chirouze C, Athan E, Alla F, Chu VH, Ralph Corey G, et al. Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study. Clin Microbiol Infect. 2013 Dec;19(12):1140-7. PubMed PMID: 23517406.
  • Carugati M, Bayer AS, Miró JM, Park LP, Guimarães AC, et al. High-dose daptomycin therapy for left-sided infective endocarditis: a prospective study from the international collaboration on endocarditis. Antimicrob Agents Chemother. 2013 Dec;57(12):6213-22. PubMed PMID: 24080644; PubMed Central PMCID: PMC3837915.
  • Marijon E, Le Heuzey JY, Connolly S, Yang S, Pogue J, et al. Causes of death and influencing factors in patients with atrial fibrillation: a competing-risk analysis from the randomized evaluation of long-term anticoagulant therapy study. Circulation. 2013 Nov 12;128(20):2192-201. PubMed PMID: 24016454.
  • Zhong L, Ng KK, Sim LL, Allen JC, Lau YH, et al. Myocardial contractile dysfunction associated with increased 3-month and 1-year mortality in hospitalized patients with heart failure and preserved ejection fraction. Int J Cardiol. 2013 Oct 3;168(3):1975-83. PubMed PMID: 23336957.
  • Lalani T, Chu VH, Park LP, Cecchi E, Corey GR, et al. In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis. JAMA Intern Med. 2013 Sep 9;173(16):1495-504. PubMed PMID: 23857547.
  • Carpenter JP, Roughton M, Pennell DJ. International survey of T2* cardiovascular magnetic resonance in β-thalassemia major. Haematologica. 2013 Sep;98(9):1368-74. PubMed PMID: 23812939; PubMed Central PMCID: PMC3762092.
  • Hohnloser SH, Shestakovska O, Eikelboom J, Franzosi MG, Tan RS, et al. The effects of apixaban on hospitalizations in patients with different types of atrial fibrillation: insights from the AVERROES trial. Eur Heart J. 2013 Sep;34(35):2752-9. PubMed PMID: 23892201.
  • Shanmugam N, Yap J, Tan RS, Le TT, Gao F, et al. Fragmented QRS complexes predict right ventricular dysfunction and outflow tract aneurysms in patients with repaired tetralogy of Fallot. Int J Cardiol. 2013 Aug 20;167(4):1366-72. PubMed PMID: 22521381.
  • Connolly SJ, Wallentin L, Ezekowitz MD, Eikelboom J, Oldgren J, et al. The Long-Term Multicenter Observational Study of Dabigatran Treatment in Patients With Atrial Fibrillation (RELY-ABLE) Study. Circulation. 2013 Jul 16;128(3):237-43. PubMed PMID: 23770747.
  • Jia X, Choy JS, Zhang ZD, Svendsen M, Zhong L, et al. Extent of load-independence of pressure-normalized stress in swine. Exp Biol Med (Maywood). 2013 Jul;238(7):821-9. PubMed PMID: 23828596.
  • Hori M, Connolly SJ, Zhu J, Liu LS, Lau CP, et al. Dabigatran versus warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and non-Asians with atrial fibrillation. Stroke. 2013 Jul;44(7):1891-6. PubMed PMID: 23743976.
  • Chin CW, Tan RS, Thumboo J. Endothelial function and arterial stiffness assessment as early surrogate markers of vascular risk in patients with systemic lupus erythematosus. Clin Exp Rheumatol. 2013 Mar-Apr;31(2):295-301. PubMed PMID: 23110754.
  • Barsic B, Dickerman S, Krajinovic V, Pappas P, Altclas J, et al. Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke. Clin Infect Dis. 2013 Jan;56(2):209-17. PubMed PMID: 23074311.
  • Chambers ST, Murdoch D, Morris A, Holland D, Pappas P, et al. HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort. PLoS One. 2013;8(5):e63181. PubMed PMID: 23690995; PubMed Central PMCID: PMC3656887.
  • Zhong L, Su B, Zhang JM, Huo Y, Leo HL, et al. Effects of stenosis on the porcine left anterior descending arterial tree. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3869-72. PubMed PMID: 24110576.
  • Zhang JM, Luo T, Huo Y, Wan M, Chua T, et al. Area stenosis associated with non-invasive fractional flow reserve obtained from coronary CT images. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3865-8. PubMed PMID: 24110575.
  • Wan M, Lim C, Zhang J, Su Y, Yeo SY, et al. Reconstructing patient-specific cardiac models from contours via Delaunay triangulation and graph-cuts. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:2976-9. PubMed PMID: 24110352.
  • Zhong L, Su B, Zhang JM, Leo HL, Tan RS. FSI simulation of intra-ventricular flow in patient-specific ventricular model with both mitral and aortic valves. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:703-6. PubMed PMID: 24109784.
  • Tan ML, Su Y, Lim CW, Selvaraj SK, Zhong L, et al. A geometrical approach for automatic shape restoration of the left ventricle. PLoS One. 2013;8(7):e68615. PubMed PMID: 23894325; PubMed Central PMCID: PMC3716701.
  • Su Y, Zhong L, Lim CW, Ghista D, Chua T, et al. A geometrical approach for evaluating left ventricular remodeling in myocardial infarct patients. Comput Methods Programs Biomed. 2012 Nov;108(2):500-10. PubMed PMID: 21507502.
  • Zhong L, Tan RS, Ghista D. Proper use of left atrial ejection force as a measure of left atrial mechanical function. Echocardiography. 2012 Aug;29(7):878-84. PubMed PMID: 22882615.
  • Athan E, Chu VH, Tattevin P, Selton-Suty C, Jones P, et al. Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices. JAMA. 2012 Apr 25;307(16):1727-35. PubMed PMID: 22535857.
  • Hankey GJ, Patel MR, Stevens SR, Becker RC, Breithardt G, et al. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol. 2012 Apr;11(4):315-22. PubMed PMID: 22402056.
  • Koh AS, Flores JL, Keng FY, Tan RS, Chua TS. Correlation between clinical outcomes and appropriateness grading for referral to myocardial perfusion imaging for preoperative evaluation prior to non-cardiac surgery. J Nucl Cardiol. 2012 Apr;19(2):277-84. PubMed PMID: 22314553.
  • Zhong L, Gobeawan L, Su Y, Tan JL, Ghista D, et al. Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot. Am J Physiol Heart Circ Physiol. 2012 Mar 15;302(6):H1306-16. PubMed PMID: 22210750; PubMed Central PMCID: PMC3311479.
  • Le T, Tan R, Huang F, Zhong L, Idapalapati S, et al. Intra-left ventricular flow distributions in diastolic and systolic phases, based on echo velocity flow mapping of normal subjects and heart failure patients, to characterize left ventricular performance outcomes of heart failure. Journal of Mechanics in Medicine and Biology. 2012; 12(5).
  • Ru San T, Chan MY, Wee Siong T, Kok Foo T, Kheng Siang N, et al. Stroke prevention in atrial fibrillation: understanding the new oral anticoagulants dabigatran, rivaroxaban, and apixaban. Thrombosis. 2012;2012:108983. PubMed PMID: 22997573; PubMed Central PMCID: PMC3444866.
  • Zhong L, Ghista DN, Tan RS. Left ventricular wall stress compendium. Comput Methods Biomech Biomed Engin. 2012;15(10):1015-41. PubMed PMID: 21547783.
  • Zhong L, Ghista D, Tan RS. Improved aorto-ventricular matching in ischemic dilated cardiomyopathy patients after surgical ventricular restoration. Med Eng Phys. 2011 Nov;33(9):1120-6. PubMed PMID: 21641262.
  • Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011 Sep 8;365(10):883-91. PubMed PMID: 21830957.
  • Yap J, Tan RS. Myocardial viability in ischemic left ventricular dysfunction. N Engl J Med. 2011 Aug 4;365(5):472; author reply 472-3. PubMed PMID: 21812691.
  • Zhong L, Su Y, Gobeawan L, Sola S, Tan RS, et al. Impact of surgical ventricular restoration on ventricular shape, wall stress, and function in heart failure patients. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1653-60. PubMed PMID: 21357513; PubMed Central PMCID: PMC3094088.
  • Zhong L, Poh KK, Lee LC, Le TT, Tan RS. Attenuation of stress-based ventricular contractility in patients with heart failure and normal ejection fraction. Ann Acad Med Singapore. 2011 Apr;40(4):179-85. PubMed PMID: 21678003.
  • Koh AS, Flores JL, Keng FY, Tan RS, Chua TS. Evaluation of the American College of Cardiology Foundation/American Society of Nuclear Cardiology appropriateness criteria for SPECT myocardial perfusion imaging in an Asian tertiary cardiac center. J Nucl Cardiol. 2011 Apr;18(2):324-30. PubMed PMID: 21107927.
  • Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, et al. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3;364(9):806-17. PubMed PMID: 21309657.
  • Kanafani ZA, Kanj SS, Cabell CH, Cecchi E, de Oliveira Ramos A, et al. Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults. Eur J Clin Microbiol Infect Dis. 2010 Oct;29(10):1203-10. PubMed PMID: 20549531.
  • Topol EJ, Bousser MG, Fox KA, Creager MA, Despres JP, et al. Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet. 2010 Aug 14;376(9740):517-23. PubMed PMID: 20709233.
  • Kirk P, He T, Anderson LJ, Roughton M, Tanner MA, et al. International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers. J Magn Reson Imaging. 2010 Aug;32(2):315-9. PubMed PMID: 20677256; NIHMSID: NIHMS207276; PubMed Central PMCID: PMC2946327.
  • Lalani T, Cabell CH, Benjamin DK, Lasca O, Naber C, et al. Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias. Circulation. 2010 Mar 2;121(8):1005-13. PubMed PMID: 20159831; NIHMSID: NIHMS451199; PubMed Central PMCID: PMC3597944.
  • Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study. Am Heart J. 2010 Mar;159(3):340-347.e1. PubMed PMID: 20211293.
  • Rufaihah AJ, Haider HK, Heng BC, Ye L, Tan RS, et al. Therapeutic angiogenesis by transplantation of human embryonic stem cell-derived CD133+ endothelial progenitor cells for cardiac repair. Regen Med. 2010 Mar;5(2):231-44. PubMed PMID: 20210583.
  • Benito N, Miró JM, de Lazzari E, Cabell CH, del Río A, et al. Health care-associated native valve endocarditis: importance of non-nosocomial acquisition. Ann Intern Med. 2009 May 5;150(9):586-94. PubMed PMID: 19414837; NIHMSID: NIHMS451194; PubMed Central PMCID: PMC3625649.
  • Eisen DP, Corey GR, McBryde ES, Fowler VG Jr, Miro JM, et al. Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid. J Infect. 2009 May;58(5):332-8. PubMed PMID: 19342103.
  • Chu VH, Miro JM, Hoen B, Cabell CH, Pappas PA, et al. Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study. Heart. 2009 Apr;95(7):570-6. PubMed PMID: 18952633.
  • Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG Jr, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med. 2009 Mar 9;169(5):463-73. PubMed PMID: 19273776; NIHMSID: NIHMS451197; PubMed Central PMCID: PMC3625651.
  • Zhong L, Sola S, Tan RS, Le TT, Ghista DN, et al. Effects of surgical ventricular restoration on left ventricular contractility assessed by a novel contractility index in patients with ischemic cardiomyopathy. Am J Cardiol. 2009 Mar 1;103(5):674-9. PubMed PMID: 19231332.
  • Zhong L, Su Y, Yeo SY, Tan RS, Ghista DN, et al. Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H573-84. PubMed PMID: 19122166; PubMed Central PMCID: PMC2660226.
  • Yeo SY, Zhong L, Su Y, Tan RS, Ghista DN. A curvature-based approach for left ventricular shape analysis from cardiac magnetic resonance imaging. Med Biol Eng Comput. 2009 Mar;47(3):313-22. PubMed PMID: 18853215.
  • Guo C, Haider HKh, Wang C, Tan RS, Shim WS, et al. Myoblast transplantation for cardiac repair: from automyoblast to allomyoblast transplantation. Ann Thorac Surg. 2008 Dec;86(6):1841-8. PubMed PMID: 19021990.
  • Durante-Mangoni E, Bradley S, Selton-Suty C, Tripodi MF, Barsic B, et al. Current features of infective endocarditis in elderly patients: results of the International Collaboration on Endocarditis Prospective Cohort Study. Arch Intern Med. 2008 Oct 27;168(19):2095-103. PubMed PMID: 18955638.
  • Baddley JW, Benjamin DK Jr, Patel M, Miró J, Athan E, et al. Candida infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008 Jul;27(7):519-29. PubMed PMID: 18283504; NIHMSID: NIHMS129767; PubMed Central PMCID: PMC2757733.
  • Yeo TC, Chan YH, Low LP, Venketasubramanian N, Lim SC, et al. Risk factor profile and treatment patterns of patients with atherothrombosis in Singapore: insight from the REACH Registry. Ann Acad Med Singapore. 2008 May;37(5):365-71. PubMed PMID: 18536821.
  • He T, Kirk P, Firmin DN, Lam WM, Chu WC, et al. Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment. J Cardiovasc Magn Reson. 2008 Feb 21;10:11. PubMed PMID: 18291040; PubMed Central PMCID: PMC2279115.
  • Caram LB, Linefsky JP, Read KM, Murdoch DR, Lalani T, et al. Leptotrichia endocarditis: report of two cases from the International Collaboration on Endocarditis (ICE) database and review of previous cases. Eur J Clin Microbiol Infect Dis. 2008 Feb;27(2):139-43. PubMed PMID: 17960435.
  • Chiaw TH, San TR, Le TJ. An adult with truncus arteriosus and unilateral pulmonary hypertension. Congenit Heart Dis. 2007 Nov-Dec;2(6):433-7. PubMed PMID: 18377438.
  • Ho KW, Tan RS, Wong KY, Tan TH, Shankar S, et al. Late complications following tetralogy of Fallot repair: the need for long-term follow-up. Ann Acad Med Singapore. 2007 Nov;36(11):947-53. PubMed PMID: 18071607.
  • Guo C, Haider HKh, Shim WS, Tan RS, Ye L, et al. Myoblast-based cardiac repair: xenomyoblast versus allomyoblast transplantation. J Thorac Cardiovasc Surg. 2007 Nov;134(5):1332-9. PubMed PMID: 17976470.
  • Tan RS. Anomalous coronary arteries and sudden death: time for action. Singapore Med J. 2007 Jun;48(6):490-1. PubMed PMID: 17538743.
  • Zhong L, Tan RS, Ghista DN, Ng EY, Chua LP, et al. Validation of a novel noninvasive cardiac index of left ventricular contractility in patients. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2764-72. PubMed PMID: 17237251.
  • Ye L, Haider HKh, Jiang S, Tan RS, Toh WC, et al. Angiopoietin-1 for myocardial angiogenesis: a comparison between delivery strategies. Eur J Heart Fail. 2007 May;9(5):458-65. PubMed PMID: 17188570.
  • Soon JL, Tan RS, Ng DC, Kwek BH, Chua YL. Paradoxical orthodeoxia in a patient with a large thoracic aortic aneurysm. Ann Acad Med Singapore. 2007 Mar;36(3):203-5. PubMed PMID: 17450266.
  • Tan RS, Partridge J, Ilsley C, Mohiaddin R. Familial complete congenital absence of the pericardium. Clin Radiol. 2007 Jan;62(1):85-7. PubMed PMID: 17145270.
  • Zhong L, Yeo SY, Su Y, Le TT, Tan RS, et al. Regional assessment of left ventricular surface shape from magnetic resonance imaging. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:884-7. PubMed PMID: 18002098.
  • Yeo SY, Zhong L, Su Y, Tan RS, Ghista DN. Analysis of left ventricular surface deformation during isovolumic contraction. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:787-90. PubMed PMID: 18002074.
  • Ye L, Haider HKh, Jiang S, Tan RS, Ge R, et al. Improved angiogenic response in pig heart following ischaemic injury using human skeletal myoblast simultaneously expressing VEGF165 and angiopoietin-1. Eur J Heart Fail. 2007 Jan;9(1):15-22. PubMed PMID: 16829190.
  • Zhong L, Ghista DN, Ng EY, Lim ST, Tan RS, et al. Explaining left ventricular pressure dynamics in terms of LV passive and active elastances. Proc Inst Mech Eng H. 2006 Jul;220(5):647-55. PubMed PMID: 16898221.
  • Su JW, Caleb MG, Tan RS, Low AF, Lim CH. Cardiac inflammatory myofibroblastic tumor as a rare cause of aortic regurgitation: a case report. J Thorac Cardiovasc Surg. 2006 Jul;132(1):150-1. PubMed PMID: 16798316.
  • Ghista DN, Zhong L, Chua LP, Ng EY, Lim ST, et al. Systolic modeling of the left ventricle as a mechatronic system: determination of myocardial fiber's sarcomere contractile characteristics and new performance indices. Mol Cell Biomech. 2005 Dec;2(4):217-33. PubMed PMID: 16705867.
  • Tan DS, Sim DK, Chan ES, Tan RS. Abciximab in the treatment of ST-segment elevation myocardial infarction. JAMA. 2005 Oct 12;294(14):1760-1; author reply 1761. PubMed PMID: 16219877.
  • Tan RS, Chen KK. Coronary artery disease: comprehensive evaluation by cardiovascular magnetic resonance imaging. Ann Acad Med Singapore. 2004 Jul;33(4):437-43. PubMed PMID: 15329754.
  • Mohiaddin RH, Burman ED, Prasad SK, Varghese A, Tan RS, et al. Glagov remodeling of the atherosclerotic aorta demonstrated by cardiovascular magnetic resonance: the CORDA asymptomatic subject plaque assessment research (CASPAR) project. J Cardiovasc Magn Reson. 2004;6(2):517-25. PubMed PMID: 15137336.
  • Tan RS, Dahdal MT, Mohiaddin RH. Contrast enhanced magnetic resonance angiography of severe aortic coarctation. Heart. 2002 Feb;87(2):98. PubMed PMID: 11796534; PubMed Central PMCID: PMC1766983.
  • Tan RS, Behr ER, McKenna WJ, Mohiaddin RH. Images in cardiovascular medicine Occult anomalous pulmonary venous drainage: the clinical value of cardiac magnetic resonance imaging. Circulation. 2002 Jan 29;105(4):E27-8. PubMed PMID: 11815442.
  • Tan RS, Mohiaddin RH. Cardiovascular applications of magnetic resonance flow measurement. Rays. 2001 Jan-Mar;26(1):71-91. PubMed PMID: 11471350.

Books and Chapters

  • Zhong L, Tan R, Su Y, Yeo S, Ghista DN, et al. Computational Cardiovascular Mechanics: Modeling and Applications in Heart Failure. First ed. Guccione JM, Kassab GS, Radcliff MB, editors. United States: Springer; 2010. Noninvasive Assessment of Left Ventricular Remodeling: Geometry, Wall Stress and Function; p.179-196.
  • Ghista DN, Zhong L, Ng E, Tan R. Cardiac perfusion & pumping engineering. Ghista DN, editor. Singapore: World Scientific Press; 2007. Characterization of cardiac dysfunction during systolic ejection; p.215-228.
  • Ghista DN, Zhong L, Tan R, Ng E. Cardiac perfusion & pumping engineering. Ghista DN, editor. Singapore: World Scientific Press; 2007. New clinically-correlated left ventricular contractility indices; p.203-214.
  • Ghista DN, Zhong L, Chua L, Tan R. Cardiac perfusion & pumping engineering. Ghista DN, editor. Singapore: World Scientific Press; 2007. Characterizing left ventricular filling performance characteristics; p.191-202.
  • Ghista DN, Liu L, Zhong L, Yeo S, Chua L, et al. Cardiac perfusion & pumping engineering. Ghista DN, editor. Singapore: World Scientific Press; 2007. Left ventricular pressure increase mechanism during isovolumic contraction, and determination of the equivalent LV myocardial fibers orientation; p.165-190.
  • Tan R, Zhong L, Chua T, Ghista DN. Cardiac perfusion & pumping engineering. Ghista DN, editor. Singapore: World Scientific Press; 2007. Quantification of perfusion using nuclear cardiac imaging; p.57-82.
  • Zhong L, Ng E, Ghista DN, Tan R, Lim S, et al. Recent advances in cardiac signal processing: an application in data mining. Acharya U, Suri J, Spaan J, Krishnan S, editors. Berlin Heidelberg: Springer; 2007. Assessment of cardiac function in filling & systolic ejection phases: a mathematical and clinical evaluation; p.263-287.
  • Ghista DN, Zhong L, Ng E, Tan R. Determination of arterial pressure pulse wave propagation velocity and arterial properties. Acharya U, Suri J, Spaan J, Krishnan S, editors. Berlin Heidelberg: Springer; 2007. Assessment of cardiac function in filling & systolic ejection phases: a mathematical and clinical evaluation; p.303-328.
  • Tan R, Johan BA. A clinical approach to medicine. Ong Y, Ng H, Woo K, Tan P, Tang O, editors. Singapore: World Scientific Press; 2005. Hypertension; p.13-27.

Research Trials

  • FIGARO/FIDELIO – finerinone in DM nephroathy
  • SPIRE – bococizumab in high CV risk subjects
  • RELAX-ASIA -serelaxin in acute heart failure among Asian subjects
  • RE-DUAL – dabigatran in subjects with atrial fibrillation and coronary stenting
  • EMPA-REG – empagliflozin in high CV risk DM
  • TECOS – sitagliptin in high CV risk DM
  • X-VERT- rivaroxaban in Af cardioversion
  • APEX – betrixaban for VTE prevention in medically ill subjects
  • APPRAISE-2 – apixaban in ACS
  • AVERROES – apixaban in AF not eligible for VKA
  • ARISTOTLE – apixaban for stroke prevention in AF
  • ROCKET-AF – rivaroxaban for stroke prevention in AF
  • RE-LY – dabigatran for stroke prevention in AF
  • EMPHASIS – eplerenone in NYHA 2 heart failure
  • STICH – surgical revascularization in ischemic cardiomyopathy
  • ICE – International collaboration in endocarditis