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Adj Assoc Prof Tan Ju Le

Adj Asst Prof Tan Ju Le from National Heart Centre Singapore

Adj Assoc Prof Tan Ju Le

MBBS (Newcastle-u-Tyne,UK), MRCP (London), FAMS (Spore), FACC, FESC

Senior Consultant

Specialty: Cardiology

Sub-specialties: Adult Congenital Heart Disease

Clinical Appointments

  • Senior Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore
  • Director of Adult Congenital Heart Disease National Heart Centre SingaporeNational Heart Centre Singapore
  • Visiting Consultant Cardiology Service KK Women's and Children's HospitalKK Women's and Children's Hospital

Profile

Adj Assoc Prof Tan Ju Le is a Senior Consultant with the Department of Cardiology at National Heart Centre Singapore (NHCS). She is also the Director of the Adult Congenital Heart Disease Programme at NHCS. Dr Tan’s subspecialty interest is in adult congenital heart disease, pulmonary hypertension and cardiac disease in pregnancy. 

She underwent further training in Adult Congenital Heart Disease at the Royal Brompton Hospital in London from 2003 to 2005.

Adj Assoc Prof Tan has written for numerous publications and is a co-author of several book chapters. She is involved in clinical trials and research in hyperlipidemia and pulmonary hypertension.

Education

  • Membership of the Royal College of Physicians, UK, 1996
  • Bachelor of Medicine and Surgery, Newcastle Medical School, UK, 1993

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Cardiology, National Heart Centre Singapore
  • Director, Adult Congenital Heart Diseases, National Heart Centre Singapore
  • Visiting Consultant, Singapore General Hospital, 2009 – Present
  • Visiting Consultant, Cardiology Service, KK Women's and Children's Hospital, 2005 – Present
  • Adjunct Associate Professor, Duke-NUS Medical School, 2019 – Present
  • Adjunct Assistant Professor, Duke-NUS Medical School, 2015 – 2018
  • Senior Lecturer, National University of Singapore (NUS) Medical School, 2012 – Present
  • Senior Clinical Lecturer, NUS Yong Loo Lin School of Medicine
  • Fellow of the European Society of Cardiology, 2011 – Present
  • Fellow of the American College of Cardiology, 2011 – Present
  • Completed 18 months fellowship in Adult Congenital Heart Disease at the Royal Brompton Hospital, London, UK in 2005
  • Fellow of the Academy of Medicine Singapore, 2003 – Present

Awards

  • ​Singapore Health Quality Service SuperStar (Clinical) Award, 2015
  • Singhealth Residency Outstanding Faculty Award, 2014
  • Singapore Health Service Quality Award – Platinum, 2013
  • Singapore Health Quality Service Award – Gold, 2012
  • Singapore Health Service Award – Silver, 2011

Research Interests

  • Tetralogy of Fallot
  • Echo imaging in congenital heart Disease
  • Pulmonary hypertension

Publications and Research Trials

  • Comparative analysis of right heart chamber remodeling after surgical and device secundum atrial septal defect closure in adults. Jie Sheng Foo, Maksym Lazu, Si Ying Pang, Phong Teck Lee, Ju Le Tan.  Journal of Interventional Cardiology. J Interv Cardiol. 2018;31:672-678.
  • Is Subdural hemorrhage after pulmonary endarterectomy underrecognised? Jonathan Yap, Wen Ruan, Alicia Chia, Kenny Loh, Foong Koon Cheah, Ai Leen Ang, Ghee Chee Phua, Duu Wen Sewa, David Jenkins, Ju Le Tan, Victor Chao, Soo Teik Lim. The Journal of Thoracic and Cardiovascular Surgery. 2018:1-4
  • Image-based computational assessment of vascular wall mechanics and hemodynamics in pulmonary arterial hypertension patients. Zambrano BA, McLean NA, Zhao X, Tan JL, Zhong L, Figueroa CA, Lee LC, Beak S.  Journal of Biomechanics [J Biomech] 2018 Feb 08; Vol 68, pp. 84-92. Date of Electronic Publication: 2017 Dec 27.
  • Percutaneous Decommissioning of left Ventricular Assist Device. Jia-Lin Soon, Ju-Le Tan, Choon-Pin Lim, Teing-Ee Tan, Swee-Yaw Tan, Ka-Lee Kerk, Kheng-Leng David Sim, Cumaraswamy Sivathasan.  Heart, Lung and Circulation (2018) 27, 853-855
  • Three-Dimensional Tricuspid Annular Motion Analysis from Cardiac Magnetic Resonance Feature-Tracking. Leng S, Jiang M, Zhao XD, Allen JC, Kassab GS, Ouyang RZ, Tan JL, He B, Tan RS, Zhong L. Ann Biomed Eng. 2016 Dec;44(12):3522-3538. [Epub 2016 Jul 19]
  • Multiple pregnancy in a primigravida with uncorrected Pentalogy of Fallot. Partana P, Tan JK, Tan JL, Tan LK. BMJ Case Rep. 2017 Jan 18;2017. Pii:bcr2016216809. doi: 10.1136/bcr-2016-216809
  • A case of successfully managed pregnancy in a patient with complex cyanotic congenital heart disease. JU Liu, WK Tan, EL Tan, JL Tan and LK Tan. Obstetric Medicine Journal 0(0) 1-5 2016.
  • Aortic Dilatation at Different Levels of the Ascending Aorta in Patients with Bicuspid Aortic Valve. Fei Qiong Huang, Kenneth WQ Guo, Liang Zhong, Fei Gao, Ju Le Tan. Annals, Academy of Medicine, Singapore. Vol 45 No. 6 June 2016.
  • Molecular pathogenesis of Marfan syndrome. Chrishan J.A. Ramachandra, Ashish Mehta, Kenneth Wei Qiang Guo, Philip Wong, Ju Le Tan, Winston Shim. International Journal of Cardiology, May 6 2015, Volume 187, Pages 585-591.
  • Pregnancy Heart Disease. Tan Ju Le. Article contributed in Heartline, Singapore Heart Foundation. March 2015 – May 2015. Pg 3.
  • Pattern of Aortic Dilatation in Different Biscupid Aortic Valve Phenotypes and its Association with Aortic Valvular Dysfunction and Elasticity. Fei Qiong Huang, MD, PhD, Ju Le Tan, MBBS, MRCP. Heart Lung and Circulation (2014) 23, 32-38.
  • Unusual Cause of Severe Pulmonary Hypertension in a young woman. Wong SS, Ju Le Tan. Annals January 2013, Vol. 42 No. 2.
  • 3-Years Post-Operative Outcome of a Recipient of Pulmonary Valve Homograft Originating from a Heart Transplant Patient in Singapore. Ling Heng Wee, Tan Ju Le, Lim Chong Hee and Lim Yeong Phang. J Clin Case Rep 2012, 2:17.
  • Emergency admissions in Asians with adult congenital heart disease. Angela S. Koh, Betty T. Yap, Ju Le Tan.  Elsevier International Journal of Cardiology 151 (2011) 54-57  
  • Angela S. Koh, Yee Jim Loh, Yeong Phang Lim, Ju Le Tan.  Ventricular septal rupture following acute myocardial infarction. Acta Cardiologica 2011 Apr;66(2): 225-230
  • Large pulmonary artery aneurysm associated with Marfan Syndrome. Peter Ting, Bodh I Jugdutt, Ju Le Tan. Int J Angiol. 2010 Spring; 19(1):e48-e50.
  • Association of Patent Ductus Arteriosus with Tetralogy of Fallot .Proceedings of Singapore Healthcare, a publication of Singhealth Academy.  Koh AS, Tan JL.  Vol 19 No 3: 2010.
  • The Impact of Transcatheter Atrial Septal Defect Closure in the Older Population.  Arif Anis Khan, MD, Ju-Le Tan, MD, W. Li, PhD, Kostas Dimopoulos, MD, PhD, Mark S. Spence, MD, Pak Chow, MD, Michael J. Mullen, MD.  JACC Intv, 2010; 3:276-281, dol:10.1016/j.jcin.2009.12.011. 2010 by the American College of Cardiology Foundation.
  • Mipomersen, an apolipoprotein B Synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Frederick J Raal, Raul D Santos, Dirk J Blom, A David Marais, Min-Ji Charng, William C Cromwell, Robin H Lachmann, Daniel Gaudet, Ju L Tan, Scott Chasan-Taber, Diane L Tribble, JoAnn D Flaim, Stanley T Crooke.   The Lancet March 14, 2010.
  • Pulmonary hypertension: an unusual presentation of an iatrogenic hepatic arterioportal fistula and its successful resolution post-embolotherapy. Chua DY, PavillionG, Tay KH, Tan JL, Chung AY. PubMed. Am Surg.2009 Jun;75(6):511-4.
  • Hepatotocellular Carcinoma-A Rare Complication Post Fontan Operation. See H. Ewe, Ju L. Tan.  Congenital Heart Disease. 2009;4:103-106.
  • Wakeboarding-related water impact trauma as a cause of fatal cardiac rupture. Jang Wen Su, Chong Hee Lim, Ju Le Tan, Yeow Leng Chua, Paul Peng Sun Chui. The Journal of Thoracic and Cardiovascular Surgery August 2007;134:506-7.
  • An Adult with Truncus Arteriosus and Unilateral Pulmonary Hypertension. Tang Hak Chiaw, Tan Ru San, Tan Ju Le. Congenital Heart Disease. 2007;2:433-437.
  • Late Complications Following Tetralogyof Fallot Repair: The Need for Long-term Follow-Up. Kay Woon Ho, Ru San Tan, Keng Yean Wong, Teng Hong Tan, Sriram Shankar, Ju Le Tan. Annals Academy of Medicine.  November 2007, Vol. 36 No. 11.
  • The right ventricular response to high afterload: Comparison between atrial switch procedure, congenitally corrected transposition of the great arteries, and idiopathic pulmonary arterial hypertension. Tan JL, Prati D, Gatzoulis MA, Gibson D, Henein MY, Li W. Am Heart J 2007; 153:681–8
  • Large Unrepaired Aortopulmonary Window – Survival into the Seventh Decade. Koh ASM, Tan JL. Echocardiography 2006 Vol. 24(1):1–3.
  • Adult Congenital Heart Disease: Moving Beyond the Paediatric Horizon. Tan JL. SGH Proceedings 2006, Vol. 15 no. 3, pg 121–126
  • Aortic root disease in tetralogy of Fallot. Tan JL, Gatzoulis MA, Ho SY.  Current Opin Cardiology, 2006, Nov;21(6): 569-72.
  • Images in Cardiology: Persistent left sided superior vena cava. KL Ho, JL Tan.  Heart 2006; 92:1046.
  • LV abscess – Unusual presentation of Endocarditis. Tan JL, Broberg C, Mullen M, Gatzoulis MA, Li W. EAE Clinical Case Reports, 1 May 2006.
  • Doppler echo-cardiographic profile and indices in the evaluation of aortic coarctation in patients before and after stenting. Tan JL, Babu-Narayan S, Henein MY, Mullen M, Li W. JACC. 2005 Sep 20; 46(6): 1045-53.
  • Intrinsic Histological Abnormalities of the Aortic Root and Ascending Aorta in Tetralogy of Fallot : Evidence of causative mechanism for aortic dilatation and Aortopathy. Tan JL, Davlouros PA, Mc Carthy KP, Gatzoulis MA, Ho SY. Circulation.  August 2005, Vol 112 no. 7, pg 961-968.
  • Emergency stent graft deployment for acute aortic rupture following primary stenting for aortic coarctation. Tan JL, Mullen M. Catheter Cardiovasc Interven. June 2005, Vol 65:306-309.
  • Images in Cardiology: Atrial Flutter with 1:1 Conduction. JL Tan, WS Teo. Heart 2002; 88:414.
  • Immediate and Mid-Term Safety and Efficacy of Single Lead VDD Pacemaker for Patients with Atrioventricular Block and Normal Sinus Node Function – A Single Centre Experience. JL Tan, LF Hsu, RML Kam, WS Teo. Ann Acad Med Singapore January 2003, Vol.32 No.1.

Reviews, invited published papers
  • Aortic root disease in tetralogy of Fallot. Tan JL, Gatzoulis MA, Ho SY. Current Opin Cardiology, 2006, Nov;21(6): 569-72

Books & book chapters
  • Aortopathy by Koichiro Niwa (Editor), Harald Kaemmerer (Editor). Published  17/2/2017 by Springer. Chapter 6: Imaging CT, Echo and MRI. Pages 75-111. Kenneth Guo, Narayan Lath, Ju Le Tan.
  • “Shunts” - Atrial Septal Defects/Abnormal Pulmonary Venous Return “Right Heart Enlargement of Uncertain Cause (Sinus Venosus Atrial Septal Defect). Ju-Le Tan, Wei Li, Elisabeth Bedard. Cases in Adult Congenital Heart Disease. Pg 1-6, 2009.
  • Rationale for Septal Defect Closure in the Elderly. Ju-Le Tan, Wei Li, Michael J. Mullen. Cases in Adult Congenital Heart Disease Pg 7-12, 2009.
  • Myocardial ischaemia in congenital heart disease - the role of non-invasive imaging  Anagnostopoulos C, Bax JJ, Nihoyiannopoulos P, van der Wall E. Tan JL, Loong C, Kilner P, Li W, Gatzoulis MA. Noninvasive Imaging of Myocardial Ischaemia. Chapter 15, pg 287-306, Springer-Verlag London 2006.

Research Trials

Principal Investigator (PI)
  • REPAIR (2016)
  • FOURIER (2013)
  • AGMEN  (2011-2013)
  • ASTRONAUT STUDY (2009-2011)
  • ALISKIREN  (2009)
  • ISIS 301012 Trial (2007)

Co-PI for the following Trials
  • Integrated computational modelling of right heart mechanics and blood flow dynamics in congenital heart disease
  • Teralogy Of Fallot (TOF) REMODELING Study; MRI-based patient-specific three-dimensional assessment of right ventricular remodeling in repaired Tetralogy of Fallot
  • United Therapies PH Study (2014)
  • Sildenafil Trial_PAH patients (PFIZER) 2014
  • DYSIS Trial (2013
  • Tecos Study (2010)
  • LEPHT Trial (PAH)
  • GRIPHON 2 / GRIPHON (2009)
  • SERAPHIN Study (2008)
  • PATENT Trial (2008)
  • PLATO Trial (2007)
  • INSPIRE ME Trial (2006)
  • EARLY Trial (2005/2006)
  • RELY Trial (2005/2006)
  • OVERTURE Study (2001