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Clin Asst Prof Nakao Masakazu

Dr Nakao Masakazu from National Heart Centre Singapore

Clin Asst Prof Nakao Masakazu

MD (Japan), FRCS-CTh (Edinburgh), Board Certified Surgeon (Japan), Board Certified Cardiovascular Surgeon (Japan)​

Senior Consultant

National Heart Centre Singapore

Specialty: Paediatric Cardiothoracic Surgery, Cardiothoracic Surgery

Conditions Treated by this Doctor:
Chest Deformity, Congenital and Paediatric Heart Diseases, Tracheal Stenosis.

Clinical Appointments

  • Senior Consultant Cardiothoracic Surgery Service KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Senior Consultant Department of Cardiothoracic Surgery National Heart Centre SingaporeNational Heart Centre Singapore

Academic Appointments

  • Adjunct Assistant Professor


Clincal Assistant Professor Nakao Masakazu obtained his medical degree from the Kyoto Prefectural University of Medicine, Japan in 1998. He completed his training in cardiothoracic surgery and also paediatric cardiothoracic surgery in Singapore and was awarded FRCS-CTh in 2011. He completed his fellowship at Great Ormond Street Hospital for Children, London in 2013. He was then appointed as the head of Heart Centre, Al Jalila Children’s Hospital, Dubai in 2018, following his service as a consultant in paediatric cardiothoracic surgery, KK Women’s and Children’s Hospital, Singapore. Currently, he is a Senior Consultant with Cardiothoracic Surgery Service, KK Women’s and Children’s Hospital since January 2020.

His research interests are in the areas of congenital heart surgery, tracheal surgery, right ventricular outflow tract reconstruction and regenerative medicine in congenital heart disease. Since 2010, he has been awarded several grants from SingHealth Foundation and National Medical Research Council.

His career goal is to establish an international-standard unit for paediatric cardiology and paediatric cardiac surgery in Singapore.


  • FRCS-CTh (Edinburgh) 2011
  • Board Certified Cardiovascular Surgeon (Japan) 2009
  • MRCS (UK) 2008
  • Board Certified Surgeon (Japan) 2002
  • MD (Kyoto, Japan) 1998

Professional Appointments and Committee Memberships

  • Senior Consultant, Cardiothoracic Surgery Service, KK Women’s and Children’s Hospital 2020 – Present
  • ​Senior Consultant, Department of Cardiothoracic Surgery, National Heart Centre Singapore, May 2020 to Present
  • Clinical Assistant Professor, Duke-NUS Medical School, August 2020 – Present
  • Head, Heart Centre, Al Jalila Children’s Hospital 2018-2019
  • Consultant, Cardiothoracic Surgery Service, KK Women’s and Children’s Hospital 2014-2018
  • Fellow, Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children 2013-2014
  • Associate Consultant, Cardiothoracic Surgery Service, KK Women’s and Children’s Hospital 2012-2013


  • Best Poster Award, 24th Annual Meeting of Asian Society of Cardiovascular and Thoracic Surgery 2016
  • Service from the Heart Award, KK Women’s and Children’s Hospital 2016
  • Gold Award, SingHealth Quality Service Award 2013
  • Best Scientific Presentation, 19th Annual Meeting of Asian Society of Cardiovascular and Thoracic Surgery, 2012
  • Best Registrar Award, SingHealth 2012
  • Service from the Heart, KK Women’s and Children’s Hospital 2012
  • Service from the Heart, KK Women’s and Children’s Hospital 2011
  • Service Quality Award (Bronze), National Heart Centre Singapore 2010

Research Interests

  • Flow analysis in congenital heart diseases/surgery
  • Valve innovation in paediatric cardiac surgery
  • Regenerative medicine in congenital heart and tracheal diseases


  • Zhu GY, Wei Y, Yuan Q, Cai L, Nakao M, Yeo JH. In vitro Assessment of the Impacts of Leaflet Design on the Hemodynamic Characteristics of ePTFE Pulmonary Prosthetic Valves. Front. Bioeng. Biotechnol. 2020, 7. (JCR Q1, IF: 5.122). doi:10.3389/fbioe.2019.00477
  • Garg RK, Thareen JK, Mehmood A, Nakao M, Basappanavar V, Jain R, Sam M, Khan AA, Di Donato RM. Implementation of on-table extubation after pediatric cardiac surgery in the developing world. J Cardiothorac Vasc Anesth. 2019(23).pii: S1053-0770(19)31201-7
  • Zhu GY, Ismail MB, Nakao M, Yuan Q, Yeo JH. Numerical and in-vitro experimental assessment of the performance of a novel designed expanded-polytetrafluoroethylene stentless bi-leaflet valve for aortic valve replacement. PLoS One 2019 Jan 30;14(1):e0210780
  • Wong JJ, Chen CK, Moorakonda RB, Wijeweera O, Tan TYS, Nakao M, Allen JC Jr., Loh TF, Lee JH. Changes in Near-Infrared Spectroscopy After Congenital Cyanotic Heart Surgery. Front Pediatr. 2018 Apr 13;6:97
  • Leow EH, Chan YH, Ng YH, Lim JKB, Nakao M, Lee JH. Prevention of Acute Kidney Injury in Children Undergoing Cardiac Surgery: A Narrative Review. World J Pediatr Congenit Heart Surg. 2018 Jan;9(1):79-90
  • Agarwal A, Nakao M, Rajadurai VS, Chandran S. Neonatal airway: challenging endotracheal intubation in infants with tracheal malformations at birth. BMJ Case Rep. 2017 Apr 13;2017pii: bcr-2016-218818.doi: 10.1136/bcr-2016-218818
  • Zhu G, Yuan Q, Yeo JH, Nakao M. Thermal treatment of expanded polytetrafluoroethylene (ePTFE) membranes for reconstruction of a valved conduit.Biomed Mater Eng. 2015;26 Suppl 1:S55-62
  • Wong JM, Cheifetz IM, Ong C, Nakao M, Lee JH. Nutrition Support for Children Undergoing Congenital Heart Surgeries: A Narrative Review. World J Pediatr Congenit Heart Surg. 2015;6(3):443-54
  • Nakao M, Ong KK, Lim YP, Wong KY. Aortic Intimal Fold in Takayasu Arteritis Causing Obstruction of Left Coronary Ostium. – Pediatr Cardiol2011; Oct;32(7):990-2.
  • Nakao M, Lim YP, Jarmin MJ, Ong BH, Chua YL. Two-stage operation for an extensive infected aortic arch - J Thorac Cardiovasc Surg 2010;139:1073-1075
  • Nakao M, Ch'ng JK, Sin YK, Chua YL, Lee CY. Acquired right-to-left shunt through an atrial septal perforation with cyanosis after percutaneous transvenous mitral commissurotomy - J Thorac Cardiovasc Surg2008;135:690-691
  • Loh YJ, Nakao M, Tan WD, Lim CH, Tan YS, Chua YL. Factors influencing radial artery size. Asian Cardiovasc Thorac Ann 2007; 15: 324- 326
  • Nakao M, Lim SL, Chua YL. Bioprosthetic mitral valve thrombosis in a patient in sinus rhythm after radiofrequency maze procedure - J Thorac Cardiovasc Surg2006 132: 1464-1465
  • NakaoM, Lim SL, Tay KH, Chua YL. Posterior pericardial approach for ascending-to-descending aortic bypass for anastomotic leak of infected interpositional graft  - J Thorac Cardiovasc Surg 2005 130: 946-947
  • Fujita N, Ikeda E, Hayashi S, Nakao M, Oshima Y, Ueshima Y, Shirono K, Hiraoka N, Hamashima T. Problems in triage training for calamities - J Jpn Soc Emer Med 2003 6(3):293-296

Research Trials

  • A new design of bileaflet valve reconstruction for right ventricular outflow tract to prevent pulmonary regurgitation during growth 2016-2019
  • Conceptual design and development of an expanded polytetrafluoroethylene valved conduit with sinus of Valsalva using 3-D printing technology 2016-2018
  • Small Calibre Tissue-engineered Vascular Graft usingin vivoAutologous Fibrous Encapsulation in a Novel Core-cylindrical Scaffold 2013-2016
  • An Expanded Polytetrafluoroethylene Trileaflet Valve for Ventricular Outflow Tract Reconstruction involving Semilunar Valves 2012-2014
  • Comparison between Monocusp, Bicusp, Trileaflet Valve, and Trileaflet Valve with Deep Coaptation in Pediatric Right Ventricular Outflow Tract Reconstruction 2010-2012