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Osimertinib

Drug Class: Commonly Known As: Category:
Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Tagrisso® Cancer-related

Osimertinib - What is it for

Osimertinib is used to treat non-small cell lung cancer that has spread to other parts of the body.
Your doctor will check for a gene mutation before starting you on this.

Osimertinib - Side Effects, Precautions, and Contraindications

What side effects can Osimertinib cause?

  • Decreased appetite
    • Take small, frequent meals throughout the day.
  • Diarrhoea
    • Drink plenty of clear fluids to replace those lost (2 litres everyday).
    • Avoid oily or spicy food and milk or dairy products.
  • Skin rash (may be acne-like), dry skin, itch
    • Moisturize your skin daily.
    • Avoid too much exposure to the sun as it may make the rash worse. Use sunscreen and covered clothing if you need to be under the sun for a long period of time.
  • Nail changes – ridges (uneven surface), discolouration or redness and tenderness around the nail folds
    • Keep your nails trimmed, clean and dry.
    • Avoid contact with harsh chemicals e.g. detergent or dish-washing liquids. Wear gloves when you are doing household chores.
  • Mouth sores
    • Rinse your mouth after meals using alcohol-free mouthwash or salt water.
    • Brush your teeth with a soft toothbrush.
  • Feeling tired or lack of energy
    • Do not drive or operate machinery when you feel tired.

Please see your healthcare professional immediately if any of the following occur:

  • Very bad diarrhoea (e.g. more than 4 times a day) that does not improve even after taking medications used to stop diarrhoea
  • Sudden onset of cough, chest pain or shortness of breath, with fever
  • Severe eye discomfort, sensitivity to light, blurred eyesight
  • Fast or abnormal heartbeat, chest pain, swelling of the hands and feet, or sudden weight gain
  • Unusual bleeding, bruising or black sticky stools
  • Fever of 38° C and above, especially with chills, pain or difficulty in passing urine
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

Before taking Osimertinib, what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication
  • You or your partner becomes pregnant or is planning for pregnancy. You should use effective birth control during and for at least
    • 4 months after stopping Osimertinib (for men)
    • 6 weeks after stopping Osimertinib (for women)
  • You are breastfeeding
    • Do not breastfeed during treatment
  • You have any other medical conditions such as heart problems or eye problems
  • You are taking or intend to take any other medication, supplements, traditional medications or herbal remedies. Some of these may affect how Osimertinib works.

What food or medicine must I avoid when I take Osimertinib?

​Avoid taking grapefruit when you are taking this medication as grapefruit may interact with your medication and increase the risk of side-effects.

Osimertinib - Dosage and How to Use

How should Osimertinib be used?

  • Take Osimertinib once a day at about the same time each day, with or without food.
  • Do not break, chew or crush the tablet. Swallow the tablet whole.
    • Inform your doctor or pharmacist if you have difficulty swallowing.

What should I do if I miss a dose?

If you forget to take a dose, take it as soon as you remember. However if it is less than 12 hours to your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time.

What should I do if I overdose?

Osimertinib - Handling and Storage

How should I handle Osimertinib safely?

How should I store Osimertinib?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Osimertinib safely?

​Pack Osimertinib into a bag and bring it back to the pharmacy where you received it from.

Osimertinib - Additional Information

​You may refer to the following website if you need more information: https://www.macmillan.org.uk/

  • Updated on Monday, September 30, 2019
  • Article contributed by PSS National Medication Information Workgroup

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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