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CRANE is a programme at the National Heart Centre Singapore (NHCS) that brings clinical care, research, innovation and education together. Our aim is to turn cardiovascular science into earlier detection, better care pathways and healthier years for ageing populations.
NHCS is delighted to be recognised as an Age-Friendly Health Systems Participant by the Institute for Healthcare Improvement (IHI).
We join a global community of more than 5,200 health systems committed to delivering consistently high-quality, person-centred care tailored to the goals and preferences of every patient.
CRANE's approach recognises that improving cardiovascular health in older adults requires more than treating disease. It requires understanding how the heart ages, identifying risk before it limits healthy ageing, and delivering care that reflects the complexity and diversity of older patients' lives.
CRANE works across four interconnected areas for cardiovascular longevity, from discovery to daily care:
CRANE delivers tailored care models and protocols that recognise the complexity and diversity of ageing.
CRANE provides knowledge and training for patients, healthcare professionals and the next generation of clinicians.
CRANE develops research and screening approaches that identify cardiovascular risk before it limits healthy ageing.
CRANE conducts real-world testing of interventions through rigorous methods.
CRANE aims to integrate autonomous technology, AI-enabled assessment and advanced imaging into clinical workflows. These tools help care teams assess patients more consistently and recognise cardiovascular risk earlier.
MOSAIC is an advanced imaging approach that assesses both the cardiac and musculoskeletal system together, providing a more comprehensive picture of a patient's overall condition.
Functional coronary angiography provides a more detailed assessment of blood flow and pressure within the coronary arteries, supporting more informed clinical decision-making.


Building on CRANE’s study portfolio and Discovery Engine, CRANE will accelerate discovery, enhance relevance of research to clinical translation.
CRANE's research portfolio translates cardiovascular ageing science into real-world interventions, tested through rigorous methods. Our studies examine how and why the heart ages, and how earlier detection and personalised approaches can lead to better care pathways and healthier years for older adults in Singapore.
COGENT studies the relationship between cardiovascular health and early cognitive change. The study focuses on preventing cognitive decline in cardiac patients, building on the understanding that heart health and cognitive health are closely connected.
The Cardiac Ageing Study is a long-term study examining how the heart changes with age in Singapore adults. It investigates why some people experience healthier cardiovascular ageing than others, with the aim of identifying what drives these differences and how that knowledge can improve care for ageing populations.
INDEPENDENCY tests personalised exercise and nutrition programmes for older adults living with cardiac frailty. The study explores whether individually tailored programmes can make a meaningful difference for this patient group.
ESCAP-AGE evaluates the role of precision-based methods in altering cardiovascular ageing. The study examines whether targeted, individualised approaches can change the way the heart ages, contributing to better long-term outcomes for patients.
This aims to deepen understanding of the biological markers associated with cardiovascular ageing, supporting earlier detection and more precise care.



Helping older cardiac patients preserve strength, function and independence through real-world trials.

Clinical teams working together to provide personalised strategies tailored to every patient’s needs.
Our team regularly engages with the wider Singapore community through public education initiatives, media appearances and outreach programmes, translating complex cardiovascular ageing science into practical information that people can act on.
CRANE develops research and screening approaches designed to detect changes in the ageing heart earlier, giving care teams the opportunity to act before conditions progress
For enquiries, to make an appointment and learn more about CRANE, please contact:
Tel: 6704 2000
Fax: 6222 9258
Email: central.appt@nhcs.com.sg
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