Ivabradine

This drug can be used for:

• Treatment of chronic stable angina in adult patients whose heart rate is equal to or more than 70 beats per minute or
• Chronic heart failure in patients whose heart rate is equal to or more than 75 beats per minute.

Ivabradine can be used to treat the symptoms of chronic stable angina, or in chronic heart failure.

Ivabradine is usually initiated at a lower dose and your doctor may increase your dose depending on your response. It is usually taken two times daily, with or after food.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for your next dose, take only the usual dose. Do not double the dosage.

Inform your doctor if you have any of the following conditions:

• Low blood pressure
• Irregular heart rate
• QT prolongation

Please check with your doctor if you are currently taking any of the medicines listed in “What food or medicine must I avoid when I take this medicine?”

Inform your doctor if you are pregnant, planning to conceive or if you are breast-feeding. You should also consult your doctor or pharmacist before taking any other medication (either prescription or over-the- counter), nutritional supplements or herbal remedies. Some of these substances can interact with your medication.

You are advised to avoid taking QT prolonging medicines such as amiodarone, sotalol, disopyramide and medicines which inhibits the breakdown of ivabradine such as ketoconazole, itraconazole, clarithromycin, erythromycin, ritonavir, diltiazem, verapamil etc.

Please check with your doctor if you are not sure.

Ivabradine may cause slow or irregular heart rate, exacerbated angina e.g. chest pain, palpitations, low or high blood pressure.

Ivabradine may also cause visual disturbances such as transient enhanced brightness in a limited area of the visual field, blurred vision, and may affect driving or operating machines in situations where sudden variations in light intensity may occur especially at night.

Please check with your doctor if you experience any unusual side effects when taking this medication.

• Keep away from children
• Keep in a cool, dry place, away from direct sunlight
• Unless instructed otherwise, store your medicines in a cool, dry place and protect them from moisture, heat and direct sunlight. Store the medicine in the original labelled container. Do not keep different types of medicine together in one container. Keep all medication out of reach of children.