Dr Kotecha Tushar

Dr Tushar Kotecha is a Consultant within the Department of Cardiology at National Heart Centre Singapore. His clinical interests include interventional cardiology, pulmonary hypertension and interventional management of acute pulmonary embolism. He completed his undergraduate and postgraduate cardiology training in London. Prior to moving to Singapore, he was an experienced Consultant Interventional Cardiologist, Director of Interventional Cardiology and lead for the acute interventional pulmonary embolism service at the Royal Free Hospital London. 

He has a strong research background, having completed a PhD in advanced cardiovascular imaging with perfusion MRI at University College London. He has published extensively in prominent international scientific journals and has been lead investigator for several research studies. 

Dr Kotecha is experienced in performing complex coronary interventions including the use of advanced coronary physiology and intracoronary imaging to optimise interventions. He also has extensive experience in performing right heart catheterisation for assessment of pulmonary hypertension and minimally invasive interventions for treatment of acute pulmonary embolism.

• Doctor of Philosophy (PhD), University College London 2020
• European (EACVI) accreditation in Cardiovascular Magnetic Resonance (CMR) Level 3, 2019
• Member of the Royal College of Physicians (MRCP) UK 2010
• Medicine (MBChB with Honors), University of Warwick, 2007 
• Pharmacy (MPharm with Honors), University of London, 2002

• Consultant, Department of Cardiology, National Heart Centre Singapore, August 2026 – Present
• Consultant Cardiologist, Department of Cardiology, Royal Free Hospital London, 2020-2026
• Director of Interventional Cardiology, Royal Free Hospital London, 2024-2026
• Lead of Interventional Acute Pulmonary Embolism Service, Royal Free Hospital London, 2023-2026
• Chair of the North London Pulmonary Embolism Network, 2024-2026
• Interventional Fellow, Hammersmith Hospital London, 2018-2020
• Clinical Research Fellow, University College London and Royal Free Hospital, 2015-2018
• Interventional Fellow, Northwick Park Hospital London, 2014-2015
• Interventional Fellow, Royal Free Hospital London, 2013-2015
• Cardiology Registrar, Watford General Hospital, 2012-2013
• Cardiology Registrar, Charing Cross and Hammersmith Hospitals London, 2011-2012

• British Cardiovascular Society Emerging Leaders Programme: Best service development project 2023
• Society of Cardiovascular Magnetic Resonance (SCMR): Winner of Early Career Award 2020
• British Cardiovascular Intervention Society (BCIS): Finalist for Young Investigator Award 2019
• SCMR: Finalist for Early Career Award 2018
• SCMR: Finalist for Early Career Award 2017
• Imperial College NHS Trust: Graham Dixon Prize for Medicine 2013
• Warwick Medical School: Bronze Medal Award 2007
• Warwick Medical School: Undergraduate Prize for Clinical Pharmacology 2007

Dr Kotecha has been a principle investigator in a number of important clinical trials on acute pulmonary embolism and coronary artery disease.  Important multi-centre international trials that Dr Kotecha has been involving in include: 

• ORBITA-2: placebo-controlled trial of PCI for stable angina
• ORBITA-COSMIC: placebo-controlled trial of coronary sinus reducer for refractory angina
• FLASH study: registry of mechanical thrombectomy using FlowTriever system for acute pulmonary embolism
• PERSEVERE study: randomised controlled trial of mechanical thrombectomy versus standard of care for high-risk pulmonary embolism
• Hi-PEITHO study: randomised controlled trial of catheter-directed thrombolysis versus standard anticoagulation for acute pulmonary embolism
• VISION-PE: prospective post-marketing registry of mechanical thrombectomy using the FlowTriever system for acute pulmonary embolism

• Foley MJ, Rajkumar CA, Ahmed-Jushuf F, Simader FA, Chotai S, Pathimagaraj RH, Mohsin M, Salih A, Wang D, Dixit P, Davies JR, Keeble TR, Cosgrove C, Spratt JC, O'Kane PD, De Silva R, Hill JM, Nijjer SS, Sen S, Petraco R, Mikhail GW, Khamis R, Kotecha T, Harrell FE, Kellman P, Francis DP, Howard JP, Cole GD, Shun-Shin MJ, Al-Lamee RK.Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial. Lancet. 2024 Apr 20;403(10436):1543-1553. doi: 10.1016/S0140-6736(24)00256-3. Epub 2024 Apr 8. PMID: 38604209.
• Rajkumar CA, Foley MJ, Ahmed-Jushuf F, Nowbar AN, Simader FA, Davies JR, O'Kane PD, Haworth P, Routledge H, Kotecha T, Gamma R, Clesham G, Williams R, Din J, Nijjer SS, Curzen N, Ruparelia N, Sinha M, Dungu JN, Ganesananthan S, Khamis R, Mughal L, Kinnaird T, Petraco R, Spratt JC, Sen S, Sehmi J, Collier DJ, Sohaib A, Keeble TR, Cole GD, Howard JP, Francis DP, Shun-Shin MJ, Al-Lamee RK; ORBITA-2 Investigators. A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina. N Engl J Med. 2023 Dec 21;389(25):2319-2330. doi: 10.1056/NEJMoa2310610. Epub 2023 Nov 11. PMID: 38015442; PMCID: PMC7615400.
• Kotecha T, Knight DS, Razvi Y, Kumar K, Vimalesvaran K, Thornton G, Patel R, Chacko L, Brown JT, Coyle C, Leith D, Shetye A, Ariff B, Bell R, Captur G, Coleman M, Goldring J, Gopalan D, Heightman M, Hillman T, Howard L, Jacobs M, Jeetley PS, Kanagaratnam P, Kon OM, Lamb LE, Manisty CH, Mathurdas P, Mayet J, Negus R, Patel N, Pierce I, Russell G, Wolff A, Xue H, Kellman P, Moon JC, Treibel TA, Cole GD, Fontana M. Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance. Eur Heart J. 2021 May 14;42(19):1866-1878. doi: 10.1093/eurheartj/ehab075. PMID: 33596594; PMCID: PMC7928984.
• Kotecha T, Martinez-Naharro A, Boldrini M, Knight D, Hawkins P, Kalra S, Patel D, Coghlan G, Moon J, Plein S, Lockie T, Rakhit R, Patel N, Xue H, Kellman P, Fontana M. Automated Pixel-Wise Quantitative Myocardial Perfusion Mapping by CMR to Detect Obstructive Coronary Artery Disease and Coronary Microvascular Dysfunction: Validation Against Invasive Coronary Physiology. JACC Cardiovasc Imaging. 2019 Oct;12(10):1958-1969. doi: 10.1016/j.jcmg.2018.12.022. Epub 2019 Feb 13. PMID: 30772231; PMCID: PMC8414332.
• Kotecha T, Chacko L, Chehab O, O'Reilly N, Martinez-Naharro A, Lazari J, Knott KD, Brown J, Knight D, Muthurangu V, Hawkins P, Plein S, Moon JC, Xue H, Kellman P, Rakhit R, Patel N, Fontana M. Assessment of Multivessel Coronary Artery Disease Using Cardiovascular Magnetic Resonance Pixelwise Quantitative Perfusion Mapping. JACC Cardiovasc Imaging. 2020 Dec;13(12):2546-2557. doi:10.1016/j.jcmg.2020.06.041. Epub 2020 Oct 1. PMID: 33011115.
• Ahmed-Jushuf F, Foley MJ, Chotai S, Rajkumar CA, Wang D, Simader FA, Macierzanka K, Chiew K, Misra S, Williams R, Konstantinou K, Din JN, Mohdnazri SR, O'Kane PD, Haworth P, Nijjer SS, Seligman H, Keeble TR, Davies JR, Clesham G, Hinton J, Spratt JC, Dungu JN, Knight D, Kotecha T, Harrell FE Jr, Howard JP, Francis DP, Shun-Shin MJ, Al-Lamee RK. Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study. Circulation. 2026 Jun 9;153(23):1795-1812. doi: 10.1161/CIRCULATIONAHA.125.078738. Epub 2026 May 8. PMID: 42100816; PMCID:PMC13236056.
• Rosenfield K, Klok FA, Piazza G, et al; HI-PEITHO Investigators. Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism. N Engl J Med. 2026 May 28;394(20):1979-1990. doi: 10.1056/NEJMoa2516567. Epub 2026 Mar 28. PMID: 41910345.
• Ioannou A, Patel R, Mansell J, Sheikh A, Thillainathan B, Razvi Y, Martinez-Naharro A, Venneri L, Lane T, Petrie A, Moon J, Manisty C, Lachmann H, Hawkins PN, Galpert J, Keene D, Kellman P, Solomon SD, Knight DS, Kotecha T, Lockie T, Patel N, Khiani R, Wechalekar A, Gillmore JD, Fontana M. Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders: The EXCALIBUR Study. J Am Coll Cardiol. 2026 May 10:S0735-1097(26)06349-7. doi: 10.1016/j.jacc.2026.04.030. Epub ahead of print. PMID: 42201646.
• Sharrack N, Knott KD, Yeo JL, Kotecha T, Brown LAE, Porcari A, Adam RD, Gulsin GS, Thirunavukarasu S, Chowdhary A, Takafuji M, Levelt E, Greenwood JP, Buckley DL, Munyombwe T, Gale CP, Kellman P, Moon JC, Fontana M, McCann GP, Swoboda PP, Plein S. Abnormal myocardial perfusion reserve and myocardial infarction determine cardiovascular outcomes in type 2 diabetes mellitus. Eur Heart J Cardiovasc Imaging. 2026 Apr 30;27(5):984-995. doi:10.1093/ehjci/jeag047. PMID: 41738351; PMCID: PMC13128276.
• Sheikh A, Achten A, Aimo A, Razvi Y, Mansell J, Rauf MU, Porcari A, Patel R, Venneri L, Martinez-Naharro A, Whelan C, Quarta C, Virsinskaite R, Feffer Barak D, Wechalekar A, Lachmann H, Knight D, Kotecha T, Kellman P, Manisty C, Moon J, Emdin M, Solomon SD, Hawkins PN, Gillmore J, Fontana M. Myocardial Amyloid Burden in Transthyretin Amyloidosis. J Am Coll Cardiol. 2026 Feb 10;87(5):505-518. doi: 10.1016/j.jacc.2025.10.054. Epub 2025 Nov 8. PMID: 41369616.
• Porcari A, Passo BD, Venneri L, Aimo A, Sezer ZI, Bandera F, Razvi Y, Sheikh A, Mansell J, Rauf MU, Zaro E, Giampieri G, Burgel C, De Caterina R, Emdin M, Petrie A, Knight DS, Virsinskaite R, Kotecha T, Wechalekar A, Lachmann H, Whelan C, Moody WE, Martinez-Naharro A, Jering KS, Solomon SD, Hawkins PN, Gillmore JD, Fontana M. Atrial Mechanical Contraction Predicts Cerebrovascular Risk in Patients With Transthyretin Amyloid Cardiomyopathy and Sinus Rhythm. J Am Coll Cardiol. 2026 Feb 9:S0735 1097(25)10564-0. doi: 10.1016/j.jacc.2025.12.033. Epub ahead of print. PMID: 41706061.
• Simader FA, Rajkumar CA, Foley MJ, et al; ORBITA-2 Investigators. Association Between Age and PCI Effectiveness in Stable CAD: Secondary Analysis of ORBITA-2. J Am Coll Cardiol. 2026 Jan 27;87(3):253-265. doi: 10.1016/j.jacc.2025.10.086. PMID: 41603507.
• Virsinskaite R, Beattie CJ, Karia N, Kotecha T, Schreiber BE, Suntharalingam J, MacKenzie Ross RV, Hughes PD, Lentaigne J, Scott-Russell AM, Parish V, Kasavkar G, Dumitru B, Thomas G, Fontana M, Muthurangu V, Coghlan JG, Knight DS. Sotatercept improves right ventricular function but is associated with new or worsening pericardial effusions: a cardiovascular magnetic resonance study in intermediate-high risk pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2026 Summer;28(1):102714. doi: 10.1016/j.jocmr.2026.102714. Epub 2026 Mar 19. PMID: 41864345; PMCID: PMC13241712.
• Patel RK, Ioannou A, Sheikh A, Razvi Y, Mansell J, Martinez-Naharro A, Knight D, Kotecha T, Porcari A, Chacko L, Brown J, Manisty C, Moon JC, Lachmann HJ, Wechalekar A, Whelan C, Venneri L, Kellman P, Hawkins PN, Gillmore JD, Fontana M. Transthyretin amyloid cardiomyopathy: natural history and treatment response assessed by cardiovascular magnetic resonance. Eur Heart J. 2025 Dec 8;46(46):5049-5058. doi: 10.1093/eurheartj/ehaf412. PMID: 40643267; PMCID: PMC12682374.
• Rajkumar CA, Foley MJ, Ahmed-Jushuf F, Chotai S, Simader FA, Mohsin M, Salih A, Ganesananthan S, Bual N, Petraco R, Nijjer SS, Sen S, Sehmi J, Ruparelia N, Dungu JN, Kabir A, Tang K, Gamma R, Davies JR, Kotecha T, Cole GD, Howard JP, Keeble TR, Clesham GJ, O'Kane PD, Harrell FE Jr, Francis DP, Shun-Shin MJ, Al-Lamee RK. The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study. Circulation. 2025 Dec 2;152(22):1541-1551. doi: 10.1161/CIRCULATIONAHA.125.074687. Epub 2025 Oct 27. PMID: 41144984; PMCID: PMC12655870.
• Netti L, Ioannou A, Martinez-Naharro A, Razvi Y, Porcari A, Venneri L, Maestrini V, Knight D, Virsinskaite R, Rauf MU, Kotecha T, Patel RK, Wechelakar A, Lachmann H, Kellman P, Manisty C, Moon J, Hawkins PN, Gillmore JD, Fontana M. Microvascular obstruction in cardiac amyloidosis. Eur J Heart Fail. 2025 Dec;27(12):2948-2951. doi: 10.1002/ejhf.3481. Epub 2024 Oct 18. PMID: 39422337; PMCID: PMC12803619.
• Yong E, Latief J, Wang Y, Erlinge D, Dahlgren A, Kotecha T, Muthurangu V, Torii R. A lumped parameter model of the coronary circulation incorporating time-varying resistance, intramyocardial pressure and vascular compliance. J Biomech. 2025 Aug;189:112679. doi: 10.1016/j.jbiomech.2025.112679. Epub 2025 Apr 6. PMID: 40480176.
• Ahmed-Jushuf F, Foley MJ, Rajkumar CA, Chotai S, Simader FA, Wang D, Macierzanka K, Sehmi J, Kanaganayagam G, Lloyd G, Keenan N, Bual N, Davies JR, Keeble TR, O'Kane PD, Haworth P, Routledge H, Kotecha T, Williams R, Din J, Nijjer SS, Curzen N, Sinha M, Ruparelia N, Gamma R, Spratt JC, Cole GD, Harrell FE Jr, Howard JP, Francis DP, Shun-Shin MJ, Al-Lamee RK; ORBITA-2 Investigators. Ischemia on Dobutamine Stress Echocardiography Predicts Efficacy of PCI: Results From the ORBITA-2 Trial. J Am Coll Cardiol. 2025 May 13;85(18):1740-1753. doi:10.1016/j.jacc.2025.02.034. PMID: 40335250.
• Foley MJ, Rajkumar CA, Ahmed-Jushuf F, Simader F, Chotai S, Seligman H, Macierzanka K, Davies JR, Keeble TR, O'Kane P, Haworth P, Routledge H, Kotecha T, Clesham G, Williams R, Din J, Nijjer SS, Curzen N, Sinha M, Petraco R, Spratt J, Sen S, Cole GD, Harrell FE Jr, Howard JP, Francis DP, Shun-Shin MJ, Al-Lamee R; ORBITA-2 Investigators. Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Coronary Artery Disease. Circulation. 2025 Jan 21;151(3):202-214. doi: 10.1161/CIRCULATIONAHA.124.072281. Epub 2024 Oct 27. PMID: 39462291; PMCID: PMC11748910.
• Brown JT, Virsinskaite R, Kotecha T, Steeden JA, Fontana M, Karia N, Schreiber BE, Ong VH, Denton CP, Coghlan JG, Muthurangu V, Knight DS. Prognostic utility of exercise cardiovascular magnetic resonance in patients with systemic sclerosis-associated pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2024 Nov 27;25(12):1712-1720. doi: 10.1093/ehjci/jeae177. PMID: 39159164; PMCID: PMC11601748.
• Sharrack N, Knott KD, Gulsin GS, Kotecha T, Brown LAE, Yeo JL, Porcari A, Adam RD, Thirunavukarasu S, Chowdhary A, Levelt E, Moon JC, McCann GP, Fontana M, Kellman P, Munyombwe T, Gale CP, Buckley DL, Greenwood JP, Swoboda PP, Plein S. Metformin associates with higher myocardial perfusion reserve and survival in type 2 diabetes mellitus patients. Sci Rep. 2024 Nov 8;14(1):27280. doi: 10.1038/s41598-024 77280-2. PMID: 39516499; PMCID: PMC11549305.
• Shiwani H, Artico J, Moon JC, et al; OxAMI Study Investigators; COVID-HEART Investigators. Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19: A Prospective, Multicenter, Cohort Study. JACC Cardiovasc Imaging. 2024 Nov;17(11):1320-1331. doi: 10.1016/j.jcmg.2024.06.008. Epub 2024 Aug 28. PMID:39207330.
• Porcari A, Masi A, Martinez-Naharro A, Razvi Y, Patel R, Ioannou A, Rauf MU, Sinigiani G, Wisniowski B, Filisetti S, Currie-Cathey J, O'Beara S, Kotecha T, Knight D, Moon JC, Sinagra G, Virsinskaite R, Gilbertson J, Venneri L, Petrie A, Lachmann H, Whelan C, Kellman P, Ravichandran S, Cohen O, Mahmood S, Manisty C, Hawkins PN, Gillmore JD, Wechalekar AD, Fontana M. Redefining Cardiac Involvement and Targets of Treatment in Systemic Immunoglobulin AL Amyloidosis. JAMA Cardiol. 2024 Nov 1;9(11):982-989. doi: 10.1001/jamacardio.2024.2555. PMID: 39167388; PMCID: PMC11339700.
• Crane JD, Joy G, Knott KD, Augusto JB, Lau C, Bhuva AN, Seraphim A, Evain T, Brown LAE, Chowdhary A, Kotecha T, Fontana M, Plein S, Ramar S, Rubino F, Kellman P, Xue H, Pierce I, Davies RH, Moon JC, Cruickshank JK, McGowan BM, Manisty C. The Impact of Bariatric Surgery on Coronary Microvascular Function Assessed Using Automated Quantitative Perfusion CMR. JACC Cardiovasc Imaging. 2024 Nov;17(11):1305 1316. doi: 10.1016/j.jcmg.2024.05.022. Epub 2024 Aug 7. PMID: 39115498.
• Knight DS, Virsinskaite R, Karia N, Cole AR, Maclean RH, Brown JT, Patel RK, Razvi Y, Venneri L, Kotecha T, Martinez-Naharro A, Kellman P, Scott-Russell AM, Schreiber BE, Ong VH, Denton CP, Fontana M, Coghlan JG, Muthurangu V. Native myocardial T1 and right ventricular size by CMR predict outcome in systemic sclerosis-associated pulmonary hypertension. Rheumatology (Oxford). 2024 Oct 1;63(10):2678-2683. doi: 10.1093/rheumatology/keae141. PMID: 38759116; PMCID: PMC11443025.
• Simader FA, Rajkumar CA, Foley MJ, Ahmed-Jushuf F, Chotai S, Bual N, Khokhar A, Gohar A, Lampadakis I, Ganesananthan S, Pathimagaraj RH, Nowbar A, Davies JR, Keeble TR, O'Kane PD, Haworth P, Routledge H, Kotecha T, Spratt JC, Williams R, Nijjer SS, Sen S, Curzen N, Sinha M, Howard JP, Cole G, Harrell FE Jr, Francis DP, Shun-Shin MJ, Al-Lamee RK; ORBITA-2 Investigators. Symptoms as a Predictor of the Placebo-Controlled Efficacy of PCI in Stable Coronary Artery Disease. J Am Coll Cardiol. 2024 Jul 2;84(1):13-24. doi: 10.1016/j.jacc.2024.04.016. Epub 2024 May 15. PMID: 38759906.
• Rajkumar CA, Foley MJ, Ahmed-Jushuf F, Simader FA, Mohsin M, Ganesananthan S, Nowbar AN, Chotai S, Sen S, Petraco R, Nijjer SS, Sehmi J, Ruparelia N, Dungu JN, Kabir A, Tang K, Gamma R, Davies JR, Kotecha T, Cole GD, Howard JP, Keeble TR, Clesham G, O'Kane PD, Harrell FE Jr, Francis DP, Shun-Shin MJ, Al-Lamee RK. N-of-1 Trial of Angina Verification Before Percutaneous Coronary Intervention. J Am Coll Cardiol. 2024 Jul 2;84(1):1-12. doi: 10.1016/j.jacc.2024.04.001. Epub 2024 May 14. PMID: 38752902. 
• Chacko L, Kotecha T, Ioannou A, Patel N, Martinez-Naharro A, Razvi Y, Patel R, Massa P, Venneri L, Brown J, Porcari A, Knott K, Manisty C, Knight D, Lockie T, Rakhit R, Lachmann H, Wechelakar A, Whelan C, Ponticos M, Moon J, González A, Gilbertson J, Riefolo M, Leone O, Xue H, Hawkins P, Kellman P, Gillmore J, Fontana M. Myocardial perfusion in cardiac amyloidosis. Eur J Heart Fail. 2024 Mar;26(3):598-609. doi: 10.1002/ejhf.3137. Epub 2024 Jan 21. PMID: 38247182.
• Ioannou A, Nitsche C, Porcari A, Patel RK, Razvi Y, Rauf MU, Martinez-Naharro A, Venneri L, Accietto A, Netti L, Bandera F, Virsinskaite R, Kotecha T, Knight D, Petrie A, Whelan C, Wechalekar A, Lachmann H, Hawkins PN, Gillmore JD, Fontana M. Multiorgan Dysfunction and Associated Prognosis in Transthyretin Cardiac Amyloidosis. J Am Heart Assoc. 2024 Feb 20;13(4):e033094. doi: 10.1161/JAHA.123.033094. Epub 2024 Feb 5. PMID: 38314569; PMCID: PMC11010096.
• Razvi Y, Ioannou A, Patel RK, Chacko L, Karia N, Riefolo M, Porcari A, Rauf MU, Starr N, Ganesananthan S, Blakeney I, Kaza N, Filisetti S, Bolhuis RE, Rowczenio D, Gilbertson J, Hutt D, Mahmood S, Lachmann HJ, Wechalekar AD, Kotecha T, Knight DS, Coghlan JG, Petrie A, Whelan CJ, Venneri L, Martinez-Naharro A, Hawkins P, Fontana M, Gillmore JD. Deep phenotyping of p.(V142I)-associated variant transthyretin amyloid cardiomyopathy: Distinct from wild-type transthyretin amyloidosis? Eur J Heart Fail. 2024 Feb;26(2):383-393. doi: 10.1002/ejhf.3088. Epub 2024 Jan 28. PMID: 37953725.
• Ioannou A, Rauf MU, Patel RK, Razvi Y, Porcari A, Martinez-Naharro A, Venneri L, Bandera F, Virsinskaite R, Kotecha T, Knight D, Petrie A, Whelan C, Wechalekar A, Lachmann H, Hawkins PN, Solomon SD, Gillmore JD, Fontana M. Albuminuria in transthyretin cardiac amyloidosis: Prevalence, progression and prognostic importance. Eur J Heart Fail. 2024 Jan;26(1):65-73. doi:10.1002/ejhf.3094. Epub 2023 Dec 18. PMID: 37997196.
• Virsinskaite R, Karia N, Kotecha T, Schreiber BE, Coghlan JG, Knight DS. Pulmonary hypertension - the latest updates for physicians. Clin Med (Lond). 2023 Sep;23(5):449-454. doi: 10.7861/clinmed.2023-23.5.Cardio4. PMID: 37775164; PMCID: PMC10541269.
• Ioannou A, Patel RK, Martinez-Naharro A, Razvi Y, Porcari A, Rauf MU, Bolhuis RE, Fernando-Sayers J, Virsinskaite R, Bandera F, Kotecha T, Venneri L, Knight D, Manisty C, Moon J, Lachmann H, Whelan C, Kellman P, Hawkins PN, Gillmore JD, Wechalekar A, Fontana M. Tracking Treatment Response in Cardiac Light-Chain Amyloidosis With Native T1 Mapping. JAMA Cardiol. 2023 Sep 1;8(9):848-852. doi: 10.1001/jamacardio.2023.2010. PMID: 37466990; PMCID: PMC10357357.
• Ioannou A, Massa P, Patel RK, Razvi Y, Porcari A, Rauf MU, Jiang A, Cabras G, Filisetti S, Bolhuis RE, Bandera F, Venneri L, Martinez-Naharro A, Law S, Kotecha T, Virsinskaite R, Knight DS, Emdin M, Petrie A, Lachmann H, Wechelakar A, Petrie M, Hughes A, Freemantle N, Hawkins PN, Whelan C, McMurray JJV, Gillmore JD, Fontana M. Conventional heart failure therapy in cardiac ATTR amyloidosis. Eur Heart J. 2023 Aug 14;44(31):2893-2907. doi: 10.1093/eurheartj/ehad347. Erratum in: Eur Heart J. 2024 Apr 7;45(14):1251. doi: 10.1093/eurheartj/ehae140. PMID: 37216684; PMCID: PMC10424879.
• Ioannou A, Patel RK, Martinez-Naharro A, Razvi Y, Porcari A, Hutt DF, Bandera F, Kotecha T, Venneri L, Chacko L, Massa P, Hanger M, Knight D, Manisty C, Moon J, Quarta C, Lachmann H, Whelan C, Kellman P, Hawkins PN, Gillmore JD, Wechelakar A, Fontana M. Tracking Multiorgan Treatment Response in Systemic AL-Amyloidosis With Cardiac Magnetic Resonance Derived Extracellular Volume Mapping. JACC Cardiovasc Imaging. 2023 Aug;16(8):1038-1052. doi:10.1016/j.jcmg.2023.02.019. Epub 2023 May 10. PMID: 37178079; PMCID:PMC10406611.
• Ioannou A, Patel RK, Razvi Y, Porcari A, Knight D, Martinez-Naharro A, Kotecha T, Venneri L, Chacko L, Brown J, Manisty C, Moon J, Wisniowski B, Lachmann H, Wechelakar A, Whelan C, Kellman P, Hawkins PN, Gillmore JD, Fontana M. Multi-Imaging Characterization of Cardiac Phenotype in Different Types of Amyloidosis. JACC Cardiovasc Imaging. 2023 Apr;16(4):464-477. doi: 10.1016/j.jcmg.2022.07.008. Epub 2022 Sep 14. PMID: 36648052.
• Knight DS, Karia N, Cole AR, Maclean RH, Brown JT, Masi A, Patel RK, Razvi Y, Chacko L, Venneri L, Kotecha T, Martinez-Naharro A, Kellman P, Scott-Russell AM, Schreiber BE, Ong VH, Denton CP, Fontana M, Coghlan JG, Muthurangu V. Distinct cardiovascular phenotypes are associated with prognosis in systemic sclerosis: a cardiovascular magnetic resonance study. Eur Heart J Cardiovasc Imaging. 2023 Mar 21;24(4):463-471. doi: 10.1093/ehjci/jeac120. PMID: 35775814;PMCID: PMC10029850.
• Perera D, Berry C, Hoole SP, et al; UK Coronary Microvascular Dysfunction Working Group. Invasive coronary physiology in patients with angina and non-obstructive coronary artery disease: a consensus document from the coronary microvascular dysfunction workstream of the British Heart Foundation/National Institute for Health Research Partnership. Heart. 2022 Dec 22;109(2):88-95. doi:10.1136/heartjnl-2021-320718. PMID: 35318254; PMCID: PMC9811089.
• Patel RK, Ioannou A, Razvi Y, Chacko L, Venneri L, Bandera F, Knight D, Kotecha T, Martinez-Naharro A, Masi A, Porcari A, Brown J, Patel K, Manisty C, Moon J, Rowczenio D, Gilbertson JA, Sinagra G, Lachmann H, Wechalekar A, Petrie A, Whelan C, Hawkins PN, Gillmore JD, Fontana M. Sex differences among patients with transthyretin amyloid cardiomyopathy - from diagnosis to prognosis. Eur J Heart Fail. 2022 Dec;24(12):2355-2363. doi: 10.1002/ejhf.2646. Epub 2022 Aug 16. PMID: 36575133; PMCID: PMC10087683.
• Martinez-Naharro A, Patel R, Kotecha T, Karia N, Ioannou A, Petrie A, Chacko LA, Razvi Y, Ravichandran S, Brown J, Law S, Quarta C, Mahmood S, Wisniowski B, Pica S, Sachchithanantham S, Lachmann HJ, Moon JC, Knight DS, Whelan C, Venneri L, Xue H, Kellman P, Gillmore JD, Hawkins PN, Wechalekar AD, Fontana M. Cardiovascular magnetic resonance in light-chain amyloidosis to guide treatment. Eur Heart J. 2022 Dec 1;43(45):4722-4735. doi: 10.1093/eurheartj/ehac363. PMID: 36239754; PMCID: PMC9712028.
• Ioannou A, Patel RK, Razvi Y, Porcari A, Sinagra G, Venneri L, Bandera F, Masi A, Williams GE, O'Beara S, Ganesananthan S, Massa P, Knight D, Martinez-Naharro A, Kotecha T, Chacko L, Brown J, Rauf MU, Manisty C, Moon J, Lachmann H, Wechelakar A, Petrie A, Whelan C, Hawkins PN, Gillmore JD, Fontana M. Impact of Earlier Diagnosis in Cardiac ATTR Amyloidosis Over the Course of 20 Years. Circulation. 2022 Nov 29;146(22):1657-1670. doi:10.1161/CIRCULATIONAHA.122.060852. Epub 2022 Nov 3. PMID: 36325894; PMCID:PMC9698091.
• Brown JT, Saigal A, Karia N, Patel RK, Razvi Y, Constantinou N, Steeden JA, Mandal S, Kotecha T, Fontana M, Goldring J, Muthurangu V, Knight DS. Ongoing Exercise Intolerance Following COVID-19: A Magnetic Resonance-Augmented Cardiopulmonary Exercise Test Study. J Am Heart Assoc. 2022 May 3;11(9):e024207. doi: 10.1161/JAHA.121.024207. Epub 2022 Apr 26. PMID: 35470679; PMCID: PMC9238618.
• Thornton GD, Shetye A, Knight DS, Knott K, Artico J, Kurdi H, Yousef S, Antonakaki D, Razvi Y, Chacko L, Brown J, Patel R, Vimalesvaran K, Seraphim A, Davies R, Xue H, Kotecha T, Bell R, Manisty C, Cole GD, Moon JC, Kellman P, Fontana M, Treibel TA. Myocardial Perfusion Imaging After Severe COVID-19 Infection Demonstrates Regional Ischemia Rather Than Global Blood Flow Reduction. Front Cardiovasc Med. 2021 Dec 7;8:764599. doi:10.3389/fcvm.2021.764599. PMID: 34950713; PMCID: PMC8688537.
• Brown JT, Kotecha T, Steeden JA, Fontana M, Denton CP, Coghlan JG, Knight DS, Muthurangu V. Reduced exercise capacity in patients with systemic sclerosis is associated with lower peak tissue oxygen extraction: a cardiovascular magnetic resonance-augmented cardiopulmonary exercise study. J Cardiovasc Magn Reson. 2021 Oct 28;23(1):118. doi: 10.1186/s12968-021-00817-1. PMID: 34706740; PMCID: PMC8554852.
• Francis R, Chong J, Ramlall M, Bucciarelli-Ducci C, Clayton T, Dodd M, Engstrøm T, Evans R, Ferreira VM, Fontana M, Greenwood JP, Kharbanda RK, Kim WY, Kotecha T, Lønborg JT, Mathur A, Møller UK, Moon J, Perkins A, Rakhit RD, Yellon DM, Bøtker HE, Bulluck H, Hausenloy DJ. Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy. Basic Res Cardiol. 2021 Oct 14;116(1):59. doi: 10.1007/s00395-021-00896-2. PMID: 34648075; PMCID:PMC8516772.
• Kotecha T, Knight DS, Moon JC, Cole GD, Fontana M. The evolution of cardiovascular COVID-19 research. Eur Heart J. 2021 Aug 7;42(30):2953-2954. doi:10.1093/eurheartj/ehab240. PMID: 34166510; PMCID: PMC8344642.
• Chacko L, Boldrini M, Martone R, Law S, Martinez-Naharrro A, Hutt DF, Kotecha T, Patel RK, Razvi Y, Rezk T, Cohen OC, Brown JT, Srikantharajah M, Ganesananthan S, Lane T, Lachmann HJ, Wechalekar AD, Sachchithanantham S, Mahmood S, Whelan CJ, Knight DS, Moon JC, Kellman P, Gillmore JD, Hawkins PN, Fontana M. Cardiac Magnetic Resonance-Derived Extracellular Volume Mapping for the Quantification of Hepatic and Splenic Amyloid. Circ Cardiovasc Imaging. 2021 Apr;14(4):e012506. doi: 10.1161/CIRCIMAGING.121.012506. Epub 2021 Apr 20. PMID:33876651.
• Kotecha T, Monteagudo JM, Martinez-Naharro A, Chacko L, Brown J, Knight D, Knott KD, Hawkins P, Moon JC, Plein S, Xue H, Kellman P, Lockie T, Patel N, Rakhit R, Fontana M. Quantitative cardiovascular magnetic resonance myocardial perfusion mapping to assess hyperaemic response to adenosine stress. Eur Heart J Cardiovasc Imaging. 2021 Feb 22;22(3):273-281. doi: 10.1093/ehjci/jeaa252. PMID:33188683; PMCID: PMC8453279.
• Yoowannakul S, Vongsanim S, Kotecha T, Fontana M, Davenport A. Hemodialysis patients with less extracellular water overload and smaller cardiac atrial chamber sizes are at greater risk of a fall in blood pressure during dialysis. Ther Apher Dial. 2021 Feb;25(1):16-23. doi: 10.1111/1744-9987.13490. Epub 2020 Apr 13. PMID: 32216122.
• Morrow AJ, Ford TJ, Mangion K, Kotecha T, Rakhit R, Galasko G, Hoole S, Davenport A, Kharbanda R, Ferreira VM, Shanmuganathan M, Chiribiri A, Perera D, Rahman H, Arnold JR, Greenwood JP, Fisher M, Husmeier D, Hill NA, Luo X, Williams N, Miller L, Dempster J, Macfarlane PW, Welsh P, Sattar N, Whittaker A, Connachie AM, Padmanabhan S, Berry C. Rationale and design of the Medical Research Council's Precision Medicine with Zibotentan in Microvascular Angina (PRIZE) trial. Am Heart J. 2020 Nov;229:70-80. doi: 10.1016/j.ahj.2020.07.007. Epub 2020 Jul 17. PMID: 32942043; PMCID: PMC7674581.
• Malik IS, Jabbour RJ, Ruparelia N, Sen S, Hadjizoulou N, Rana B, Chukwuemeka AO, Gopalan D, Kotecha T, Mikhail GW. Rescue Valve-in-Valve-in-Valve TAVR for Acute Transvalvular Aortic Regurgitation. Cardiovasc Revasc Med. 2020 Nov;21(11S):11-13. doi: 10.1016/j.carrev.2020.07.002. Epub 2020 Jul 6. PMID:32747197.
• Xue H, Tseng E, Knott KD, Kotecha T, Brown L, Plein S, Fontana M, Moon JC, Kellman P. Automated detection of left ventricle in arterial input function images for inline perfusion mapping using deep learning: A study of 15,000 patients. Magn Reson Med. 2020 Nov;84(5):2788-2800. doi: 10.1002/mrm.28291. Epub 2020 May 7. PMID: 32378776; PMCID: PMC9373024.
• Xue H, Davies RH, Brown LAE, Knott KD, Kotecha T, Fontana M, Plein S, Moon JC, Kellman P. Automated Inline Analysis of Myocardial Perfusion MRI with Deep Learning. Radiol Artif Intell. 2020 Oct 21;2(6):e200009. doi: 10.1148/ryai.2020200009. PMID: 33330849; PMCID: PMC7706884.
• Little CD, Kotecha T, Candilio L, Jabbour RJ, Collins GB, Ahmed A, Connolly M, Kanyal R, Demir OM, Lawson LO, Wang B, Firoozi S, Spratt JC, Perera D, MacCarthy P, Dalby M, Jain A, Wilson SJ, Malik I, Rakhit R. COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group. Open Heart. 2020 Oct;7(2):e001432. doi: 10.1136/openhrt-2020-001432. PMID: 33106441; PMCID: PMC7592245.
• Knight DS, Kotecha T, Razvi Y, Chacko L, Brown JT, Jeetley PS, Goldring J, Jacobs M, Lamb LE, Negus R, Wolff A, Moon JC, Xue H, Kellman P, Patel N, Fontana M. COVID-19: Myocardial Injury in Survivors. Circulation. 2020 Sep 15;142(11):1120-1122. doi: 10.1161/CIRCULATIONAHA.120.049252. Epub 2020 Jul 14. PMID: 32673505; PMCID: PMC7492396.
• Knott KD, Seraphim A, Augusto JB, Xue H, Chacko L, Aung N, Petersen SE, Cooper JA, Manisty C, Bhuva AN, Kotecha T, Bourantas CV, Davies RH, Brown LAE, Plein S, Fontana M, Kellman P, Moon JC. The Prognostic Significance of Quantitative Myocardial Perfusion: An Artificial Intelligence-Based Approach Using Perfusion Mapping. Circulation. 2020 Apr 21;141(16):1282-1291. doi: 10.1161/CIRCULATIONAHA.119.044666. Epub 2020 Feb 14. PMID: 32078380; PMCID:PMC7176346.
• Augusto JB, Nordin S, Vijapurapu R, Baig S, Bulluck H, Castelletti S, Alfarih M, Knott K, Captur G, Kotecha T, Ramaswami U, Tchan M, Geberhiwot T, Fontana M, Steeds RP, Hughes D, Kozor R, Moon JC. Myocardial Edema, Myocyte Injury, and Disease Severity in Fabry Disease. Circ Cardiovasc Imaging. 2020 Mar;13(3):e010171. doi: 10.1161/CIRCIMAGING.119.010171. Epub 2020 Mar 2. PMID: 32114828.
• Baggiano A, Boldrini M, Martinez-Naharro A, Kotecha T, Petrie A, Rezk T, Gritti M, Quarta C, Knight DS, Wechalekar AD, Lachmann HJ, Perlini S, Pontone G, Moon JC, Kellman P, Gillmore JD, Hawkins PN, Fontana M. Noncontrast Magnetic Resonance for the Diagnosis of Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2020 Jan;13(1 Pt 1):69-80. doi: 10.1016/j.jcmg.2019.03.026. Epub 2019 Jun 12. PMID: 31202744.
• Hausenloy DJ, Kharbanda RK, Møller UK, et al; CONDI-2/ERIC-PPCI Investigators. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Lancet. 2019 Oct 19;394(10207):1415-1424. doi: 10.1016/S0140-6736(19)32039-2. Epub 2019 Sep 6. PMID: 31500849; PMCID: PMC6891239.
• Knight DS, Kotecha T, Martinez-Naharro A, Brown JT, Bertelli M, Fontana M, Muthurangu V, Coghlan JG. Cardiovascular magnetic resonance-guided right heart catheterization in a conventional CMR environment - predictors of procedure success and duration in pulmonary artery hypertension. J Cardiovasc Magn Reson. 2019 Sep 9;21(1):57. doi: 10.1186/s12968-019-0569-9. PMID: 31495338; PMCID: PMC6732841.
• Yoowannakul S, Kotecha T, Fontana M, Davenport A. Do Pre-Hemodialysis Estimates of Extracellular Volume Excess Using Bioimpedance and N-Terminal Brain Natriuretic Peptide Correlate With Cardiac Chamber Size Measured by Magnetic Resonance Imaging? Ther Apher Dial. 2019 Aug;23(4):362-368. doi: 10.1111/1744-9987.12779. Epub 2018 Dec 21. PMID: 30467978.
• Hausenloy DJ, Lim MX, Chan MHH, Paradies V, Francis R, Kotecha T, Knight DS, Fontana M, Kellman P, Moon JC, Bulluck H. Interrogation of the infarcted and salvaged myocardium using multi-parametric mapping cardiovascular magnetic resonance in reperfused ST-segment elevation myocardial infarction patients. Sci Rep. 2019 Jun 21;9(1):9056. doi: 10.1038/s41598-019-45449-9. PMID: 31227761; PMCID: PMC6588689.
• Knight DS, Zumbo G, Barcella W, Steeden JA, Muthurangu V, Martinez-Naharro A, Treibel TA, Abdel-Gadir A, Bulluck H, Kotecha T, Francis R, Rezk T, Quarta CC, Whelan CJ, Lachmann HJ, Wechalekar AD, Gillmore JD, Moon JC, Hawkins PN, Fontana M. Cardiac Structural and Functional Consequences of Amyloid Deposition by Cardiac Magnetic Resonance and Echocardiography and Their Prognostic Roles. JACC Cardiovasc Imaging. 2019 May;12(5):823-833. doi: 10.1016/j.jcmg.2018.02.016. Epub 2018 Apr 18. PMID: 29680336.
• Martinez-Naharro A, Kotecha T, Norrington K, Boldrini M, Rezk T, Quarta C, Treibel TA, Whelan CJ, Knight DS, Kellman P, Ruberg FL, Gillmore JD, Moon JC, Hawkins PN, Fontana M. Native T1 and Extracellular Volume in Transthyretin Amyloidosis. JACC Cardiovasc Imaging. 2019 May;12(5):810-819. doi: 10.1016/j.jcmg.2018.02.006. Epub 2018 Mar 14. PMID: 29550324.
• Kotecha T, Martinez-Naharro A, Yoowannakul S, Lambe T, Rezk T, Knight DS, Hawkins PN, Moon JC, Muthurangu V, Kellman P, Rakhit RD, Gillmore JD, Jeetley P, Davenport A, Fontana M. Acute changes in cardiac structural and tissue characterisation parameters following haemodialysis measured using cardiovascular magnetic resonance. Sci Rep. 2019 Feb 4;9(1):1388. doi: 10.1038/s41598-018-37845-4. PMID: 30718606; PMCID: PMC6362126.
• Kotecha T, Martinez-Naharro A, Gillmore JD, Hawkins PN, Fontana M. Reply: Amyloidosis in the Era of Mass Spectrometry-Based Proteomics. J Am Coll Cardiol. 2018 Oct 9;72(15):1881. doi: 10.1016/j.jacc.2018.08.1036. PMID: 30286939.
• Kotecha T, Martinez-Naharro A, Treibel TA, Francis R, Nordin S, Abdel-Gadir A, Knight DS, Zumbo G, Rosmini S, Maestrini V, Bulluck H, Rakhit RD, Wechalekar AD, Gilbertson J, Sheppard MN, Kellman P, Gillmore JD, Moon JC, Hawkins PN, Fontana M. Myocardial Edema and Prognosis in Amyloidosis. J Am Coll Cardiol. 2018 Jun 26;71(25):2919-2931. doi: 10.1016/j.jacc.2018.03.536. PMID: 29929616.
• Francis R, Kellman P, Kotecha T, Baggiano A, Norrington K, Martinez-Naharro A, Nordin S, Knight DS, Rakhit RD, Lockie T, Hawkins PN, Moon JC, Hausenloy DJ, Xue H, Hansen MS, Fontana M. Prospective comparison of novel dark blood late gadolinium enhancement with conventional bright blood imaging for the detection of scar. J Cardiovasc Magn Reson. 2017 Nov 21;19(1):91. doi:10.1186/s12968-017-0407-x. PMID: 29162123; PMCID: PMC5696884.
• Guttmann OP, Jones DA, Gulati A, Kotecha T, Fayed H, Patel D, Crake T, Ozkor M, Wragg A, Smith EJ, Weerackody R, Knight CJ, Mathur A, O'Mahony C. Prevalence and outcomes of coronary artery perforation during percutaneous coronary intervention. EuroIntervention. 2017 Aug 4;13(5):e595-e601. doi:10.4244/EIJ-D-16-01038. PMID: 28414656.
• Martinez-Naharro A, Treibel TA, Abdel-Gadir A, Bulluck H, Zumbo G, Knight DS, Kotecha T, Francis R, Hutt DF, Rezk T, Rosmini S, Quarta CC, Whelan CJ, Kellman P, Gillmore JD, Moon JC, Hawkins PN, Fontana M. Magnetic Resonance in Transthyretin Cardiac Amyloidosis. J Am Coll Cardiol. 2017 Jul 25;70(4):466-477. doi: 10.1016/j.jacc.2017.05.053. PMID: 28728692.
• Bulluck H, Bryant JA, Lim MX, Tan XW, Ramlall M, Francis R, Kotecha T, Cabrera-Fuentes HA, Knight DS, Fontana M, Moon JC, Hausenloy DJ. Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping. Sci Rep. 2017 Jul 7;7(1):4871. doi:10.1038/s41598-017-05127-0. PMID: 28687810; PMCID: PMC5501789.
• Koganti S, Eleftheriou D, Brogan PA, Kotecha T, Hong Y, Rakhit RD. Microparticles and their role in coronary artery disease. Int J Cardiol. 2017 Mar 1;230:339-345. doi: 10.1016/j.ijcard.2016.12.108. Epub 2016 Dec 22. PMID:28040277.
• Mavroudis CA, Kotecha T, Chehab O, Hudson J, Rakhit RD. Superior long term outcome associated with native vessel versus graft vessel PCI following secondary PCI in patients with prior CABG. Int J Cardiol. 2017 Feb 1;228:563-569. doi: 10.1016/j.ijcard.2016.11.031. Epub 2016 Nov 14. PMID:27875735.
• Kotecha T, Rakhit RD. Acute coronary syndromes. Clin Med (Lond). 2016 Dec;16(Suppl 6):s43-s48. doi: 10.7861/clinmedicine.16-6-s43. PMID: 27956440; PMCID: PMC6329574.
• Koganti S, Kotecha T, Rakhit RD. Choice of Intracoronary Imaging: When to use Intravascular Ultrasound or Optical Coherence Tomography. Interv Cardiol. 2016 May;11(1):11-16. doi: 10.15420/icr.2016:6:1. PMID: 29588699; PMCID:PMC5808711.
• Ahmad Y, Nijjer S, Cook CM, El-Harasis M, Graby J, Petraco R, Kotecha T, Baker CS, Malik IS, Bellamy MF, Sethi A, Mikhail GW, Al-Bustami M, Khan M, Kaprielian R, Foale RA, Mayet J, Davies JE, Francis DP, Sen S. A new method of applying randomised control study data to the individual patient: A novel quantitative patient-centred approach to interpreting composite end points. Int J Cardiol. 2015 Sep 15;195:216-24. doi: 10.1016/j.ijcard.2015.05.109. Epub 2015 May 23. PMID: 26048380.
• Kotecha T, Fox K. Investigating suspected heart failure. BMJ. 2013 Apr 24;346:f2442. doi: 10.1136/bmj.f2442. PMID: 23616032.