Clin Asst Prof Lau Wai Zhen Clement

Clinical Assistant Professor Clement Lau is an Associate Consultant from the Department of Cardiology at National Heart Centre Singapore. Clin Asst Prof Lau studied medicine at University of Edinburgh and was awarded a PhD in cardiovascular pharmacology from Barts and The London medical school, Queen Mary University of London, UK. He went on to complete his Cardiology training in the UK with a focus in advanced cardiovascular imaging (echocardiography and cardiac MRI). Clin Asst Prof Lau is actively involved in cardiovascular research with his main interests in cardiac MRI, cardiac metabolism, cardiomyopathies and clinical trials.

• PhD, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK, 2021
• Postgraduate Diploma in Medical Education, University College London, UK, 2016
• MRCP (UK), 2013
• MBChB with Honours, University of Edinburgh, UK, 2010
• BMedSci (Hons) in Immunology, University of Edinburgh, UK, 2007

• Associate Consultant, Department of Cardiology, National Heart Centre Singapore, August 2024 - Present
• Clinical Assistant Professor, Duke NUS Medical School, 3 February 2025 - Present
• Clinical Senior Lecturer, NUS Yong Loo Lin School of Medicine

• SingHealth Duke NUS ACP Nurturing Clinician Researcher Scheme (NCRS) Award, 2025

1.   Lau C, Primus C, Shabbir A et al. Accelerating inflammatory resolution in humans to improve endothelial function and vascular health: Targeting the non-canonical pathway for NO. Redox Biology 2025: 82:103592.

2.   Lau C, Nyathi N, Jere B, Khan JN. Low-dose dobutamine stress cardiovascular magnetic resonance imaging to assess aortic stenosis severity in left ventricular systolic dysfunction and severe mitral annular calcification.  Int J Cardiovasc Imaging 2025; 41(5):1009-1010

3.   Rathod KS, Mathur A, Shabbir A, Khambata RS, Lau C et al. The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial. eClinicalMedicine 2024;77: 102885.

4.   Crane J, Joy G, Knott K, Augusto JB, Lau C et al. The Impact of Bariatric Surgery on Coronary Microvascular Function Assessed Using Automated Quantitative Perfusion CMR JACC Cardiovasc Imaging. 2024 Jul 24:S1936-878X(24)00239-0.

5.   Tran P, Lau C, Joshi M, Kuehl M, Maddock H, Banerjee P. Exploring changes in myocyte structure, contractility and energetics from mechanical unloading in heart failure patients undergoing ventricular assist device implantation: a systematic review and meta-analysis. Heart, Lung and Circulation. 2024 Aug;33(8):1097-1116

6.   Lau C. Inorganic nitrate and nitrite in cardioprotection. Conditioning Medicine. Conditioning Medicine 2023. 6(4): 131-137

7.   Shabbir A, Chhetri I, Khambata RS, Parakaw T, Lau C et al. A double-blind, randomised, placebo-controlled parallel study to investigate the effect of sex and dietary nitrate on COVID-19 vaccine-induced vascular dysfunction in healthy men and women: protocol of the DiNOVasc-COVID-19 study. Trials 2023;24(1):593.

8.   Lau C, Gul U, Liu B, Captur G, Hothi SS. Cardiovascular Magnetic Resonance Imaging in Familial Dilated Cardiomyopathy. Medicina 2023; 59(3): 439.

9.   Lau C, Elshibly MM, Kanagala P, Khoo JP, Arnold RJ, Hothi SS. The role of cardiac magnetic resonance imaging in the assessment of heart failure with preserved ejection fraction. Front Cardiovasc Med. 2022; 9:922398.

10. Davies RH, Augusto JB, Bhuva A, Hui X, Treibel TA, Yang Y, Hughes RK, Bai W, Lau C, Shiwani H, Fontana M, Kozor R, Herrey A, Lopes LR, Maestrini V, Rosmini S, Petersen SE, Kellman P, Rueckert D, Greenwood JP, Captur G, Manisty C, Schelbert E, Moon JC. Precision Measurement of Cardiac Structure and Function in Cardiac MR using Machine Learning.  Journal of Cardiovascular Magnetic Resonance, 2022. 24(1):16.

11. Lau C, Shabbir A, Rathod KS et al. Inorganic nitrate attenuates endothelial dysfunction consequent to systemic inflammation. European Heart Journal, Volume 42, Issue Supplement_1, October 2021

12. Gee L, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP, Filomena F, Khambata RS, Gupta AK, Moon JC, Kapil V, Ahluwalia A. ‘Repurposing’ of xanthine oxidoreductase in the non-canonical pathway for nitric oxide generation reduces cardiac dysfunction. British Journal of Pharmacology. 2021†Authors contributed equally to this work.

13. Joy G, Artico J, Kurdi H, Seraphim A, Lau C et al. Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers. JACC Cardiovasc Imaging, 2021. 14(11):2155-2166

14. Bhuva A, Treibel TA, Seraphim A, Scully P, Knott KD, Augusto JB, Torlasco C, Menacho K, Lau C et al. Measurement of T1 Mapping in Patients With Cardiac Devices: Off-Resonance Error Extends Beyond Visual Artifact but Can Be Quantified and Corrected. Front. Cardiovasc. Med. 2021. 8:631366.

15. Augusto JB, Davies, EH, Bhuva AN, Knott KK, Serpahim A, Alfarih M, Lau C et al. Diagnosis and risk stratification in hypertrophic cardiomyopathy using machine learning wall thickness measurement: a comparison with human test-retest performance. Lancet Digital Health, 2021. 3(1);E20-28.

16. Augusto JB, Johner N, Shah D, Nordin S, Knott KD, Rosmini S, Lau C et al. The myocardial phenotype of Fabry disease pre-hypertrophy and pre-detectable storage. Eur Heart J Cardiovasc Imaging 2021.  22(7):790-799. 

17. Lau CWZ, Hamers AJP, Rathod KS et al. Randomised, double-blind, placebo-controlled clinical trial investigating the effects of inorganic nitrate in hypertension-induced target organ damage: protocol of the NITRATE-TOD study in the UK. BMJ Open. 2020 Jan 21;10(1):e034399.

18. Bhuva A, Bai W, Lau C et al.  A Multicenter, Scan-Rescan, Human and Machine Learning CMR Study to Test Generalizability and Precision in Imaging Biomarker Analysis. Circulation: Cardiovascular Imaging. 2019; 12(10).

19. Lau C, Burd C, Abeles D, Sherman D. Decision making in venous thromboembolism prophylaxis: Is LWMH being inappropriately withheld from patients admitted with chronic liver disease? Clinical Medicine. 2015; 15(1): 31-4.

20. Lau C, Barron A, Mcdonagh S, Screeche-Powell C, Francis DP, Mayet J, Manisty C. A heart-failure led one-stop diagnostic service for breathlessness: initial experiences and diagnostic yield. European Heart Journal 2014; 35 (Abstract Supplement), 1008

21. Lau C, Redgrave L, Kayan K. The implantable loop recorder in a case of recurrent unexplained syncope. Journal of the American Geriatric Society, 2012 Feb; 60(2): 369-70.

22. Pedersen CM, Cruden NL, Schmidt MR, Lau C, Bøtker HE, Kharbanda RK, Newby DE. Remote ischemic preconditioning prevents systemic platelet activation associated with ischemia-reperfusion injury in humans. Journal of Thrombosis and Haemostasis, 2011; 9(2): 404-7.

23. O’Connor RA, Prendergast CT, Sabatos CA, Lau CWZ, Leech MD, Wraith DC and Anderton SM.  Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis.  The Journal of Immunology, 2008; 181: 3750-3754.