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Asst Prof Chin Woon Loong Calvin

Asst Prof Chin Woon Loong Calvin from National Heart Centre Singapore

Asst Prof Chin Woon Loong Calvin

​MD, MRCP (UK), FAMS, FESC

Senior Consultant

National Heart Centre Singapore

Specialty: Cardiology

Sub-specialties: Cardiac Magnetic Resonance Imaging, Echocardiography

Clinical Appointments

  • Senior Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore
  • Director, Cardiac Magnetic Resonance Imaging National Heart Centre SingaporeNational Heart Centre Singapore

Academic Appointments

  • Research EXCO SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme

Profile

Assistant Professor Calvin Chin is a Senior Consultant and Clinican Scientist at National Heart Centre Singapore, and an Assistant Professor at the Duke-NUS Medical School. He is certified in echocardiography and cardiovascular magnetic resonance imaging. Asst Prof Chin graduated from Loma Linda University, California in 2003 and completed his cardiology training at the National Heart Centre Singapore in 2012.

With the support from the National Medical Research Council, Asst Prof Chin completed the Masters of Clinical Investigation at the National University Singapore and a PhD program at the University of Edingburgh at 2010 and 2015 respectively. He was awarded the Transition Award and Clinican Scientist Award by the NMRC in 2015 and 2018, respectively. His research examines the mechanisms mediating myocardial hypertrophy and fibrosis in patients with hypertensisve heart disease, using non-invasive imaging techniques and biochemical markers.

In recognition of his research, Asst Prof Chin has received several national and international awards, including the American College of Cardiology Young Investigator Award (2015), British Heart Valve Society Young Investigator Award (2015), American Heart Association Young Investigator Award (2018) and the SingHealth Publish Award (2015 and 2016)

Education

  • PhD from the University of Edinburgh, Scotland, UK, 2015
  • Master of Clinical Investigation (MCI) from the National University of Singapore, 2010
  • MRCP (UK), Diploma of Membership of the Royal Colleges of Physicians (UK), 2008
  • Doctor in Medicine (MD) from Loma Linda University, Loma Linda, California, USA, 2003
  • BSc summa cum laude from LaSierra University, California, USA, 1998

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Cardiology, National Heart Centre Singapore, May 2019 to Present
  • Director, Cardiac Magnetic Resonance Imaging, National Heart Centre Singapore
  • Research EXCO, SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme
  • Fellow of the Academy of Medicine, Singapore
  • Fellow of the Royal College of Physicians UKFellow of the Academy of Medicine, Singapore
  • Fellow of the European Society of Cardiology

Awards

  • Clinican Scientist Award – Investigator, National Medical Research Council, 2018
  • American Heart Association Young Investigator Award, 2018
  • American College of Cardiology Young Investigator Award (Clinical Investigations), 2015
  • British Heart Valve Society Young Investigator, 2014
  • Singhealth Publication Award (Outstanding), 2015, 2016
  • Transition Award, National Medical Research Council, 2015
  • SingHealth Talent Development Fund Award, 2014
  • AHA Cardiovascular Radiology and Intervention (CVRI) Early Career Investigator Travel Stipend, 2013
  • NRF-MOH Healthcare Research Scholarship (PhD), 2012 
  • NRF-MOH Healthcare Research Scholarship (MCI), 2008 

Research Interests

  • ​Cardiac imaging
  • Hypertensive heart disease
  • Left ventricular hypertrophy
  • Myocardial fibrosis

Publications

  • Paradoxical higher myocardial wall stress and increased cardiac remodeling despite lower mass in females. Phua AIH, Le TT, Tara SW, DeMarvao A, Duan J, Toh DF, Ang B, Bryant JA, O'Regan DP, Cook SA, Chin CWL. J Am Heart Assoc. 2020; 9(4):e014781
  • Extracellular myocardial volume in patients with aortic stenosis. Everett RJ, Treibel TA, Fukui M, Lee H, Rigolli M, Singh A, Bijsteveld P, Tastet L, Musa TA, Dobson L, Chin C, Captur G, Om SY, Wiesemann S, Ferreira VM, Peichnik SK, Schulz-Menger J, Schelbert EB, Clavel MA, Newby DE, Myerson SG, Pibarot P, Lee S, Cavalcante JL, Lee SP, McCann GP, Greenwood JP, Moon JC, Dweck MR. J Am Coll Cardiol. 2020; 75(3):304-316
  • Feasibility to perform T2* mapping postcontrast administration in reperfused STEMI patients for the detection of intramyocardial hemorrhage. Bulluck H, Chowdhury N, Lim MX, Allen JC, Bryant JA, Chan MY, Chan MHH,Chin CWL, Ho HH, Lim ST, Tan ST, Tan JW, Wong PE, Yeo KK, Cook SA, Hausenloy DJ. J Magn Reson Imaging. 2020; 51(2):644-645
  • Wu D, Dou J, Chai X, Bellis C, Wilm A, Shih CC, Soon WWJ, Bertin N, Lin CB, Khor CC, DeGiorgio M, Cheng S, Bao L, Karnani N, Hwang WYK, Davila S, Tan P, Shabbir A, Moh A, Tan EK, Foo JN, Goh LL, Leong KP, Foo RSY, Lam CSP, Richards AM, Cheng CY, Aung T, Wong TY, Ng HH;SG10K Consortium (Chin CWL), Liu J, Wang C. Large-scale whole-genome sequencing of three diverse Asian populations in Singapore. Cell. 2019; 179(3):736-749
  • Teo JX, Davila S, Yang C, Hii AA, Pua CJ, Yap J, Tan SY, Sahlen A,Chin CWL, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P, Lim WK. Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological ageing. Commu Biol. 2019; 2(1):361

  • Plasma desmosine and abdominal aortic aneurysm diseaseMordi IR, Forsythe RO, Gellatly C, Iskandar Z, McBride OM, Saratzis A, Chambers R, Chin C, Brown MJ, Newby DE, Lang CC, Huang JTJ, Choy AM.  J Am Heart Assc. 2019; 8(20):e013743

  • Sex differences in left ventricular remodelling, myocardial fibrosis and mortality after aortic valve replacementSingh A, Musa TA, Treibel TA, Vassilou VS, Captur G,Chin C, Dobson LE, Pica S, Loudon M, Mailey T, Riggoli M, Foley JRJ, Bijsterveld P, Law GR, Dweck MR, Myerson SG, Prasad SK, Moon JC, Greenwood J, McCann GP. Heart. 2019; 105(23):1818

  • Impact of systemic vascular risk factors on the choriocapillaries using optical coherence tomography angiography in patients with systemic hypertension. Chua J,Chin CWL, Tan B, Wong SH, Devarajan K, Le TT, Ang M, Wong TY, Schmetterer L. . Sci Rep. 2019; 9(1):5819

  • Impact of hypertension on retinal microvascular changes using optical coherence tomographic angiography. Chua J,Chin C, Hong J, Chee ML, Le TT, Ting DSW, Wong TY, Schmetterer L. J Hypertens. 2019; 37(3):572

  • Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians: 6-year longitudinal study. Chua J, Chee ML,Chin CWL, Tham YC, Tan N, Lim SH, Aung T, Cheng CY, Wong TY, Schmetterer L.  Br J Ophthalmol. 2019; 103(2):196-202

  • Incidence and predictors of left ventricular thrombus by cardiovascular magnetic resonance in acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention: a meta-analysis. Bulluck H, Chan MHH, Paradies V, Yellon RL, Ho HH, Chan MY,Chin CWL, Tan JW, Hausenloy DJ. J Cardiovasc Magn Reson 2018; 20:72

  • High-sensitivity cardiac troponins in cardio-healthy subjects: a cardiovascular magnetic resonance imaging study. Aw TC, Huang WT, Le TT, Pua CJ, Ang B, Phua SK, Yeo KK, Cook SA,Chin CWL. . Sci Rep. 2018; 18(8):15409

  • Myocardial scar and mortality in severe aortic stenosis: Data from the BSCMR Valve Consortium. Musa T, Treibel T, Vassilou V, Captur G, Singh A,Chin C, Dobson L, Pica S, Loudon M, Malley T, Rigolli M, Foley JR, Bijsterveld P, Law GR, Dweck M, Myerson S, McCann G, Prasad S, Moon JC, Greenwood J. Circulation. 2018; 138:1935

  • Progression of hypertrophy and myocardial fibrosis in aortic stenosis: a multicenter cardiac magnetic resonance study. Everett RJ, Tastet L, Clavel MA,Chin CWL, Capoulade R, Vassiliou VS, Kwiencinski J, Gomez M, van Beek EJR, White AC, Prasad SK, Larose E, Tuck C, Semple S, Newby DE, Pibarot P, Dweck MR. Circ Cardiovasc Imaging. 2018; 11:e007451

  • Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes. Walsh R, Buchan R, Wilk A, John S, Felkin LE, Thomson KL, Chiaw TH, Chin CW, Pua CJ, Raphael C, Prasad S, Barton PJ, Funke B, Watkins H, Ware JS, Cook SA. Euro Heart J 2017; 38(46):3461-3468.

  • Cai J, Bryant JA, Le TT, Su B, de Marvao A, O'Regan DP, Cook SA, Chin CW. Fractal analysis of left ventricular trabeculations is associated with impaired myocardial deformation in healthy Chinese. J Cardiovasc Magn Reson 2017; 19:102

  • Adverse prognosis associated with asymmetric myocardial thickening in aortic stenosis. Chin CW, Kwiencinski J, Everett RJ, White AC, Semple S, Yeung E, Jenkins WJ, Shah AS, Koo M, Mirsadraee S, Lang CC, Mills N, Prasad SK, Jansen MA, Japp AG, Newby DE, Dweck MR.  Eur Heart J Cardiovasc Imaging 2018; 19(3):347-356

  • Lim WK, Davila S, Teo JX, Yang C, Pua CJ, Blocker C, Lim JQ, Yap J, Tan SY, Sahlen A,Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P. Beyond fitness tracking: the use of consumer grade wearable data from normal volunteers in cardiovascular and lipidomics research. PLoS Biol. 2018; 16:e2204285

  • Effects of Aortic Valve Replacement on Severe Aortic Stenosis and Preserved Systolic Function: Systematic Review and Network Meta-analysis. Zheng Q, Djohan AH, Lim E, Ding ZP, Ling LH, Shi L, Chan ES,Chin CWL.  Sci Rep. 2017; 11(7):5092

  • Novel Index of Maladaptive Myocardial Remodeling in Hypertension. Goh VJ, Le TT, Bryant J, Wong JI, Su B, Lee CH, Pua CJ, Sim CPY, Ang B, Aw TC, Cook SA,Chin CWL.  Circ Cardiovasc Imaging 2017; 10(9):e006840

  • Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis. Chin CW, Everett R, Kwiecinski J, Vesey A, Yeung E, Esson G, Jenkins W, Koo M, Mirsadraee S, White A, Japp A, Prasad S, Semple S, Newby D, Dweck M.  JACC Cardiovasc imaging 2017; 10(11):1320-1333

  • Disparity Between Indications for and Utilization of Implantable Cardioverter Defibrillators in Asian Patients With Heart Failure. Chia YMF, Teng TK, Tan ESJ, Tay WT, Richards MA,Chin CWL, Shimizu W, Park SW, Hung CL, Ling LH, Ngarmukos T, Omar R, Siswanto BB, Narasimhan C, Reyes EB, Yu CM, Anand I, MacDonald MR, Yap J, Zhang S, Finkelstein EA, Lam CSP.  Circ Cardiovasc Qual Outcomes 2017; 10(11):e003651

  • Cardiac myosin-binding protein C is a novel marker of myocardial injury and fibrosis in aortic stenosis. Anand A,Chin C, Shah ASV, KwieciÅ Ski J, Vesey A, Cowell J, Weber E, Kaier T, Newby DE, Dweck M, Marber MS, Mills NL.  Heart 2017;104:1101-1108.

  • Titin-truncating variants affect heart function in disease cohorts and the general population. Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Linke WA, Kovalik JP, O'Regan D, Ware JS, Hubner N, Cook SA. Nat Genet. 2017;49:46-53

  • Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes. Walsh R, Buchan R, Wilk A, John S, Felkin LE, Thomson KL, Chiaw TH, Chin CW, Pua CJ, Raphael C, Prasad S, Barton PJ, Funke B, Watkins H, Ware JS, Cook SA. Eur Heart J. 2017 Jan 11 [Epub ahead of print].

  • Assessing exercise cardiac reserve using real-time cardiovascular magnetic resonance. Le TT, Bryant JA, Ting AE, Ho PY, Su B, Teo RC, Gan JS, Chung YC, O'Regan DP, Cook SA, Chin CW. J Cardiovasc Magn Reson 2017;19(1):7.

  • Adverse prognosis associated with asymmetric myocardial thickening in aortic stenosis. Chin CW, Kwiencinski J, Everett RJ, White AC, Semple S, Yeung E, Jenkins WJ, Shah AS, Koo M, Mirsadraee S, Lang CC, Mills N, Prasad SK, Jansen MA, Japp AG, Newby DE, Dweck MR. Eur Heart J Cardiovasc Imaging. 2017 Mar 30 [Epub ahead of print].

  • Stress cardiovascular magnetic imaging. Le TT, Huang W, Bryant JA, Cook SA, Chin CW. Expert Rev Cardiovasc. Ther. 2017;15:181-189. (Review)

  • Gender differences in native myocardial T1 in a healthy Chinese volunteer cohort. Bulluck H, Bryant JA, Tan JZ, Go YY, Le TT, Tan RS, Lim TK, Tang HC, Lath N, Low AS, Chin CW, Cook SA, Hausenloy DJ. Cardiovasc Imaging Asia 2017 Mar 30 [Epub ahead of print].

  • A clinical risk score of myocardial fibrosis predicts adverse outcomes in aortic stenosis. Chin CW, Messika-Zeitoun D, Shah ASV, Lefevre G, Bailleul S, Yeung ENW, Koo M, Mathieu T, Semple SI, Mills NL, Vahanian A, Newby DE, Dweck MR. Eur Heart J. 2016;37:713-723.

  • T1 characteristics of interstitial pulmonary fibrosis on 3T MRI – a predictor of early interstitial change? Mirsadraee S, Tse M, Kershaw L, Semple S, Schembri N, Chin C, Murchison JT, Hirani N, van Beek EJ. Quant Imaging Med Surg. 2016;6(1):42-49.

  • The role of cardiac biochemical markers in aortic stenosis. Chin CW, Djohan AH, Lang CC. Biomarkers. 2016;21(4):316-327.

  • Paradoxical low gradient aortic stenosis: the HFpEF of aortic stenosis. Chin CW, Ding ZP, Lam CSP, Ling LH. J Am Coll Cardiol. 2016;67(20):2447-2448.

  • Cardiovascular magnetic resonance assessment of the heart and aorta in Chinese at 3T. Le TT, Tan RS, De Deyn M, Goh E, Han Y, Leong B, Cook SA, Chin CW. J Cardiovasc Magn Reson. 2016;18(1):21. 

  • Chest pain with a blue hand – simultaneous coronary and left subclavian artery thrombosis. Chin CY, Chin CW, Chiam P, Tan RS. AsiaIntervention. 2016.

  • Myocardial fibrosis and cardiac decompensation in aortic stenosis. Chin CW, Everett R, Kwiecinski J, Vesey A, Yeung E, Esson G, Jenkins W, Koo M, Mirsadraee S, White A, Japp A, Prasad S, Semple S, Newby D, Dweck M. JACC Cardiovasc Imaging. 2016 Dec 21 [Epub ahead of print] 

  • Paradoxical low-flow low-gradient aortic stenosis: advanced severe disease, a new entity or a progression of disease? Chin CW. Heart 2015;101:1079.

  • Valvular (18)F-fluoride and (18)F-fluorodeoxyglucose uptake predict disease progression and clinical outcome in patients with aortic stenosis. Jenkins WS, Vesey AT, Shah AS, Pawade TA, Chin CW, White AC, Fletcher A, Cartlidge TR, Mitchell AJ, Pringle MA, Brown OS, Pessotto R, McKillop G, Van Beek EJ, Boon NA, Rudd JH, Newby DE, Dweck MR. J Am Coll Cardiol. 2015;66(10):1200.

Research Trials