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Asst Prof Chin Woon Loong Calvin

Asst Prof Chin Woon Loong Calvin from National Heart Centre Singapore

Asst Prof Chin Woon Loong Calvin

​MD, MRCP (UK), FAMS, FESC

Senior Consultant

Specialty: Cardiology

Sub-specialties: Cardiac Magnetic Resonance Imaging, Echocardiography

Clinical Appointments

  • Senior Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore
  • Director, Cardiac Magnetic Resonance Imaging National Heart Centre SingaporeNational Heart Centre Singapore

Academic Appointments

  • Research EXCO SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme

Profile

​Asst Prof Calvin Chin is a Senior Consultant with the Department of Cardiology, and the Director of Cardiac Magnetic Resonance Imaging at the National Heart Centre Singapore. 

Asst Prof Chin is a Clinician Scientist, and is in the Research EXCO of SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme. He is also certified in echocardiography and cardiovascular magnetic resonance imaging.

Education

  • PhD from the University of Edinburgh, Scotland, UK, 2015
  • Master of Clinical Investigation (MCI) from the National University of Singapore, 2010
  • MRCP (UK), Diploma of Membership of the Royal Colleges of Physicians (UK), 2008
  • Doctor in Medicine (MD) from Loma Linda University, Loma Linda, California, USA, 2003
  • BSc summa cum laude from LaSierra University, California, USA, 1998

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Cardiology, National Heart Centre Singapore, May 2019 to Present
  • Director, Cardiac Magnetic Resonance Imaging, National Heart Centre Singapore
  • Research EXCO, SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme
  • Member of the British Society of Echocardiography
  • Member of the European Society of Cardiology, European Association of Cardiovascular Imaging, Working Group on Valvular Heart Disease
  • Member of the Royal College of Physicians UK 
  • Member of the Singapore Medical Association
  • Fellow of the Academy of Medicine, Singapore
  • Fellow of the European Society of Cardiology

Awards

  • Clinican Scientist Award – Investigator, National Medical Research Council, 2019
  • American College of Cardiology Young Investigator Award (Clinical Investigations), 2015
  • British Heart Valve Society Young Investigator, 2014
  • Singhealth Publication Award (Outstanding), 2015, 2016

Research Interests

  • ​Cardiac imaging
  • Hypertensive heart disease
  • Left ventricular hypertrophy
  • Myocardial fibrosis

Publications and Research Trials

  • Titin-truncating variants affect heart function in disease cohorts and the general population. Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Linke WA, Kovalik JP, O’Regan D, Ware JS, Hubner N, Cook SA. Nat Genet. 2017;49:46-53
  • Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes. Walsh R, Buchan R, Wilk A, John S, Felkin LE, Thomson KL, Chiaw TH, Chin CW, Pua CJ, Raphael C, Prasad S, Barton PJ, Funke B, Watkins H, Ware JS, Cook SA. Eur Heart J. 2017 Jan 11 [Epub ahead of print].
  • Assessing exercise cardiac reserve using real-time cardiovascular magnetic resonance. Le TT, Bryant JA, Ting AE, Ho PY, Su B, Teo RC, Gan JS, Chung YC, O’Regan DP, Cook SA, Chin CW. J Cardiovasc Magn Reson 2017;19(1):7.
  • Adverse prognosis associated with asymmetric myocardial thickening in aortic stenosis. Chin CW, Kwiencinski J, Everett RJ, White AC, Semple S, Yeung E, Jenkins WJ, Shah AS, Koo M, Mirsadraee S, Lang CC, Mills N, Prasad SK, Jansen MA, Japp AG, Newby DE, Dweck MR. Eur Heart J Cardiovasc Imaging. 2017 Mar 30 [Epub ahead of print].
  • Stress cardiovascular magnetic imaging. Le TT, Huang W, Bryant JA, Cook SA, Chin CW. Expert Rev Cardiovasc. Ther. 2017;15:181-189. (Review)
  • Gender differences in native myocardial T1 in a healthy Chinese volunteer cohort. Bulluck H, Bryant JA, Tan JZ, Go YY, Le TT, Tan RS, Lim TK, Tang HC, Lath N, Low AS, Chin CW, Cook SA, Hausenloy DJ. Cardiovasc Imaging Asia 2017 Mar 30 [Epub ahead of print].
  • A clinical risk score of myocardial fibrosis predicts adverse outcomes in aortic stenosis. Chin CW, Messika-Zeitoun D, Shah ASV, Lefevre G, Bailleul S, Yeung ENW, Koo M, Mathieu T, Semple SI, Mills NL, Vahanian A, Newby DE, Dweck MR. Eur Heart J. 2016;37:713-723.
  • T1 characteristics of interstitial pulmonary fibrosis on 3T MRI – a predictor of early interstitial change? Mirsadraee S, Tse M, Kershaw L, Semple S, Schembri N, Chin C, Murchison JT, Hirani N, van Beek EJ. Quant Imaging Med Surg. 2016;6(1):42-49.
  • The role of cardiac biochemical markers in aortic stenosis. Chin CW, Djohan AH, Lang CC. Biomarkers. 2016;21(4):316-327.
  • Paradoxical low gradient aortic stenosis: the HFpEF of aortic stenosis. Chin CW, Ding ZP, Lam CSP, Ling LH. J Am Coll Cardiol. 2016;67(20):2447-2448.
  • Cardiovascular magnetic resonance assessment of the heart and aorta in Chinese at 3T. Le TT, Tan RS, De Deyn M, Goh E, Han Y, Leong B, Cook SA, Chin CW. J Cardiovasc Magn Reson. 2016;18(1):21. 
  • Chest pain with a blue hand – simultaneous coronary and left subclavian artery thrombosis. Chin CY, Chin CW, Chiam P, Tan RS. AsiaIntervention. 2016.
  • Myocardial fibrosis and cardiac decompensation in aortic stenosis. Chin CW, Everett R, Kwiecinski J, Vesey A, Yeung E, Esson G, Jenkins W, Koo M, Mirsadraee S, White A, Japp A, Prasad S, Semple S, Newby D, Dweck M. JACC Cardiovasc Imaging. 2016 Dec 21 [Epub ahead of print] 
  • Paradoxical low-flow low-gradient aortic stenosis: advanced severe disease, a new entity or a progression of disease? Chin CW. Heart 2015;101:1079.
  • Valvular (18)F-fluoride and (18)F-fluorodeoxyglucose uptake predict disease progression and clinical outcome in patients with aortic stenosis. Jenkins WS, Vesey AT, Shah AS, Pawade TA, Chin CW, White AC, Fletcher A, Cartlidge TR, Mitchell AJ, Pringle MA, Brown OS, Pessotto R, McKillop G, Van Beek EJ, Boon NA, Rudd JH, Newby DE, Dweck MR. J Am Coll Cardiol. 2015;66(10):1200.
  • Left ventricular hypertrophy with strain and aortic stenosis. Chin CW, Shah AVS, Vassiliou V, Cowell SJ, Doris M, Kwok TC, Semple S, Zamvar V, White AC, McKillop G, Boon NA, Prasad SK, Mills NL, Newby DE, Dweck MR. Circulation 2014;130:1607-1616. 
  • Optimization and comparison of myocardial T1 techniques at 3T in patients with aortic stenosis. Chin CW, Semple S, Malley T, White AC, Mirsadraee S, Weale PJ, Prasad S, Newby DE, Dweck MR.  Eur Heart J Cardiovasc Imaging. 2014;15(5):556-65.
  • 18F-NaF uptake is a marker of active calcification and disease progression in patients with aortic stenosis. Dweck MR, Jenkins WS, Vesey AT, Pringle MA, Chin CW, Malley TS, Cowie WJ, Tsampasian V, Richardson H, Fletcher A, Wallace WA, Pessotto R, Van Beek EJ, Boon NA, Rudd JH, Newby DE. Cir Cardiovasc Imaging. 2014;7(2):371-8.
  • Endothelial function is associated with myocardial diastolic function in women with systemic lupus erythematosus. Chin CW, Chin CY, Ng M, Le TT, Huang FQ, Fong KY, Thumboo J, Tan RS. Rheumatol Int. 2014;34(9):1281-1285.
  • Echocardiography underestimates stroke volume and aortic valve area: implications for the classification of patients with small-area low-gradient aortic stenosis. Chin CW, Khaw HJ, Luo E, Tan SW, White AC, Newby DE, Dweck MR. Can J Cardiol. 2014;30(9):1064-1072.
  • High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis. Chin CW, Shah AVS, McAllister DA, Cowell SJ, Alam S, Langrish JP, Strachan F, Hunter A, Choy AM, Lang CC, Walker S, Boon NA, Newby DE, Mills NL, Dweck MR. Eur Heart J.  2014;35(34):2312-2321.
  • Expert Rev. Cardiovasc. Chin CW, Vassiliou V, Jenkins WSA, Prasad SK, Newby DE, Dweck MR. Markers of left ventricular decompensation in aortic stenosis. Ther. 2014;12(7):901-912.
  • Assessment of arterial elastance and ventricular-arterial coupling in patients with systemic lupus erythematosus. Chin CW, Le TT, Gao F, Ng MXR, Chin CY, Huang FQ, Fong KY, Thumboo J, Tan RS.  Int J Cardiol. 2014;176(2):504-505.
  • Endothelial function and arterial stiffness assessment as early surrogate markers of vascular risk in patients with systemic lupus erythematosus. Chin CW, Tan RS, Thumboo J. Clin Exp Rheumatol. 2013;31(2):295.
  • Lipid goal attainment and prescription behavior in Asian patients with acute coronary syndromes: Experience from a tertiary hospital. Chin CW, Fei G, Le TT, Tan RS. Clinical Med Cardiol. 2013;7:51-57.
  • What can we learn about valvular heart disease from PET/CT? Jenkins WS, Chin C, Rudd JH, Newby DE, Dweck MR. Future Cardiol. 2013;9(5):657.
  • Small Valve Area with Low Gradient Aortic Stenosis: Beware the Hard Hearted. Dweck MR, Chin C, Newby DE. J Am Coll Cardiol. 2013;62:2339-40.
  • The ARIC predictive model reliably predicted risk of Type II Diabetes in Asian populations. Chin CW, San ECH, Ma S, Heng D, Tan M, Lee J, Tai ES, Salim A. BMC Med Res Methodol. 2012;12(1):48.
  • An octogenarian with painless type A aortic dissection and cardiac tamponade. Chin CW, Koh N, Wong A, Lai SH, Chao V. Postgrad Med J. 2012;88(1046):729.
  • Free floating thrombus in the right heart causing pulmonary embolism. Chin CW, Lim ST, Ho KW, Ding ZP. Postgrad Med J. 2010;86(1015):307.
  • CME Article: Electrocardiographical Case. Young woman with epilepsy. Chin C, Kam RM, Hsu LF. Singapore Med J. 2007;48(2):177.

Research Trials