Profile
Dr Chen is a senior staff physician and serves as a consultant in pediatric surgery at KKH, specializing in minimal invasive surgery.
Actively involved in national and international committees including:
Member of the National Liver Transplant Workgroup on Education, Research, and Innovation and Member of the Evidence and Guidelines Committee of the European Pediatric Surgeons Association (EUPSA)
Adjunct Research Scientist at the Bioprocessing Technology Institute, A-STAR.
Dedicated educator serving as; Adjunct Assistant Professor at DUKE-NUS, Clinical Lecturer at YLL School of Medicine, NUS, Clinical Lecturer at LKC School of Medicine, NTU.
Recognized with awards:
SingHealth Quality Service (Gold) in 2022, Mad Scientist Award in 2018 and NMRC Research Fellowship in 2016
Education
- MRCS (Glasgow) 2011
- PhD (Biochemistry) National University of Singapore 2007
- MMed (Surgery) School of Medicine, Wuhan University, 1998
- MBBS School of Medicine, Wuhan University, China 1995
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Professional Appointments and Committee Memberships
- Senior Staff Physician, Department of Pediatric Surgery, KK Women’s and Children’s Hospital 2022-Present
- Member: the National Liver Transplant Workgroup on Education, Research, and Innovation, 2023-present
- Member: Value-driven care (VDC) committee for hernia, KKH, 2022-present
- Member: The Evidence and Guidelines Committee of the European Pediatric Surgeons Association (EUPSA), 2021-present
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Awards
- Quality Service Award (Gold) , SingHealth 2022
- Quality Service Award (Hero) , SingHealth 2021
- Quality Service Award (Silver) , SingHealth 2019
- Mad Scientist Award, DUKE-NUS 2018
- NMRC Research Fellowship, NMRC 2016
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Research Interests
- Clinical risk factors and molecular mechanism of necrotising enterocolitis
- Ischemia and reperfusion injury in organ transplant
- Pathogenesis of biliary atresia
- Evidence-based Medicine in pediatric surgery
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Publications
- Elective Delivery versus Expectant Management for Gastroschisis: A Systematic Review and Meta-Analysis. Chen Y; Zhao JS; Alganabi M; Mesas-Burgos C; Eaton S; Wester T; Pierro A. European journal of pediatric surgery 2023; 33(1):2-10
- Conservative antibiotic treatment of pediatric acute uncomplicated appendicitis during the COVID-19 pandemic: a prospective comparative cohort study. Tan PP; Yap TL; Cheong YL; Rai R; Choo C; Ong C; Low Y; Jacobsen A; Loh A; Ong LY; Chen Y. Pediatric surgery international 2022; 39(1):60
- Extravesical vs. intravesical ureteric reimplantation for primary vesicoureteral reflux: A systematic review and meta-analysis. Law ZW; Ong C; Yap TL; Loh A; Joseph U; Sim SW; Ong LY; Low Y; Jacobsen A; Chen Y. Frontiers in pediatrics 2022; 10:935082
- Time course response of inflammatory markers in pediatric appendicitis. Chiang J Y; Angus MI; Nah SA; Jacobsen AS; Low Y; Choo C; Yap TL, Chen Y. Pediatric surgery international 2020; 36(4):493-500
- Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation Koike Y, Li B, Ganji N, Zhu H, Miyake H, Chen Y, Lee C, Janssen Lok M, Zozaya C, Lau E, Lee D, Chusilp S, Zhang Z, Yamoto M, Wu RY, Inoue M, Uchida K, Kusunoki M, Delgado-Olguin P, Mertens L, Daneman A, Eaton S, Sherman PM, Pierro A. Nat Commun 2020; 11(1):4950-4965
- Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis. Li B, Lee C, O'Connell JS, Antounians L, Ganji N, Alganabi M, Cadete M, Nascimben F, Koike Y, Hock A, Botts SR, Wu RY, Miyake H, Minich A, Maalouf MF, Zani-Ruttenstock E, Chen Y, Johnson-Henry KC, De Coppi P, Eaton S, Maattanen P, Delgado Olguin P, Zani A, Sherman PM, Pierro A. Cell death & disease 2020; 11(9):1-12
- Mechanical versus Chemical Pleurodesis after Bullectomy for Primary Spontaneous Pneumothorax: A Systemic Review and Meta-Analysis. Sim KR; Nah SA; Loh A; Ong LY; Chen Y. European journal of pediatric surgery 2020; 30(6):490-496
- Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis. Chen Y, Koike Y, Chi L, Ahmed A, Miyake H, Li B, Lee C, Delgado-Olguín P, Pierro A Dis Model Mech. 2019; 12(12):
- Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis Li B, Hock A, Wu RY, Minich A, Botts SR, Lee C, Antounians L, Miyake H, Koike Y, Chen Y, Zani A, Sherman PM, Pierro A PloS One 2019; 14(1)
- Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis Li B, Lee C, Cadete M, Zhu H, Koike Y, Hock A, Wu RY, Botts SR, Minich A, Alganabi M, Chi L, Zani-Ruttenstock E, Miyake H, Chen Y, Mutanen A, Ngan B, Johnson-Henry KC, De Coppi P, Eaton S, Määttänen P, Delgado-Olguin P, Sherman PM, Zani A, Pierro A. Cell death & disease 2019; 10(10):1-11
- The role of ischemia in necrotizing enterocolitis. Chen Y; Chang TE; Lian WQ; Lu H; Roy S; Laksmi NK; Low Y; Krishnaswamy G; Pierro A; Ong C. Journal of pediatric surgery 2016; 51(8):1255-61
- Formula feeding and systemic hypoxia synergistically induce intestinal hypoxia in experimental necrotizing enterocolitis. Chen Y; Koike Y; Miyake H; Li B; Lee C; Hock A; Zani A; Pierro A. Pediatric surgery international 2016; 32(12):1115-1119
- Postoperative steroid therapy for biliary atresia: Systematic review and meta-analysis. Chen Y; Nah SA; Chiang LW; Krishnaswamy G; Low Y. Journal of pediatric surgery 2015; 50(9):1590-4
- Transanal endorectal pull-through versus transabdominal approach for Hirschsprung's disease: a systematic review and meta-analysis. Chen Y; Nah SA; Laksmi NK; Ong C; Chua HY; Jacobsen A; Low Y. Journal of pediatric surgery 2013; 48(3):642-51
- Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity. Chen Y; Lu H; Liu Q; Huang GC; Lim CP; Zhang LH; Hao AJ; Cao XM. The Journal of biological chemistry 2012; 287(32):27227-35
- NFAT directly regulates Nkx2-5 transcription during cardiac cell differentiation. Chen Y; Cao XM Biology of the cell 2009; 101(6):335-49
• Mitochondria and calcium signaling in embryonic development. Cao XM; Chen Y. Seminars in cell & developmental biology 2009; 20(3):337-45
- The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis. Chen Y; Yuen WH; Fu JL; Huang GC; Melendez AJ; Ibrahim F; Lu H; Cao XM. Molecular and cellular biology 2007; 27(18):6420-32
- AlphaCP1 mediates stabilization of hTERT mRNA by autocrine human growth hormone. Emerald BS*; Chen Y*; Zhu T; Zhu Z; Lee KO; Gluckman PD; Lobie PE. The Journal of biological chemistry 2007; 282(1):680-90
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Research Trials
- Home-Initiated-Programme-to-Prepare-for-Operation (HIPPO) study: a Randomised Controlled Trial to Evaluate Effect of Animation Video on Paediatric Peri-operative Anxiety 2017-2020
- A Collaborative Multicenter open-label, non-inferiority, randomized controlled trial comparing appendectomy versus non-operative treatment for acute uncomplicated appendicitis in children (APPY Trial) 2017-2022
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