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Assoc Prof Ye Lei

Principal Investigator 
National Heart Research Institute Singapore 
National Heart Centre Singapore

Assoc Prof Ye graduated with a medical degree from the Shanghai Medical University, Shanghai, China in 1996. He received his PhD from the Faculty of Medicine, National University of Singapore (NUS) in 2005. After completion of his PhD, Assoc Prof Ye continued his research at NUS and was promoted to Senior Research Scientist in July 2010. In Sept 2010, Assoc Prof Ye received an invitation for a position at the University of Minnesota, USA, as was appointed an Assistant Professor there. He returned to Singapore to join the National Heart Centre Singapore in Nov 2014.

Assoc Prof Ye's interest lies in the fields of cardiovascular research. He has published more than 70 papers in peer-reviewed journals, including European Journal of Heart Failure, Diabetologia, Biomaterials, Circulation Research, Circulation, and Cell Stem Cell. His research has received various national and international awards at prestigious scientific congresses, including Singapore Cardiac Society (2006, 2007, 2009), Asian Society for Cardiovascular Surgery (2004-2006), Asian Pacific Congress of Cardiology (2009), European Society of Cardiovascular Surgery (2005), European Society of Cardiology (2007), and American Heart Association (2006 & 2011). He was on the final shortlist for the Vivien Thomas Young Investigator Competition at the Annual Scientific Session of American Heart Association in 2006.


  • Principal Investigator, National Heart Research Institute Singapore, National Heart Centre Singapore
  • Associate Professor, Duke-NUS Medical School, Singapore, 2019 - Present


  • Berry JL,Zhu WQ, Tang YL, Krishnamurthy P, Ge Y,Cooke JP, Chen YB, Garry DJ, Yang HT,Rajasekaran NS,Koch WJ,Li S, Domae K, Qin GJ, Cheng K, Kamp TJ, Ye L, Hu SJ, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD,Liao RL, Pu WT, Wang YB,Ping PP, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang JY. Circ Res. 2019 Jan.; 124(1): 161-169.
  • Ye L, D'Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, Tee GZ, Pua CJ, Pena EM, Cheng RB, Chen WC, Abdurrachim D, Lalic J, Tan RS, Lee TH, Zhang JY, Cook SA, Early regenerative capacity in the porcine heart. Circulation 2018 Dec.;138(24): 2798-2808. (Corresponding author)
  • Su LP, Kong XC, Lim SY, Loo SJ, Tan SH, Poh KK, Dutton J, Stewart C, Cook S, Su XF, Ma JH, Zhang JY, Ye L. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Research and Therapy. 15 Nov. 2018. 9:313. (Corresponding author)
  • Tan SH, and Ye L. Maturation of pluripotent stem cells derived cardiomyocytes: a critical step for drug discovery and cell therapy. J Cardiovasc Transl. Res. 2018 Oct;11(5): 375-392. JIF=2.319. (Corresponding author)
  • Ye L, Chang YH, Xiong Q, Zhang PY, Zhang LY, Somasundaram P, Lepley M, Swingen C, Su LP, Wendel JS, Guo J, Jang A, Rosenbush D, Greder L, Dutton JR, Zhang JH, Kamp TJ, Kaufman DS, Ge Y, Zhang JY. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell 2014; 15(6): 750-761.



  • Rabago Prize Award. The 54th International Congress for European Society of Cardiovascular Surgery. Athens Greece, May 19th - 22nd (2005)
  • C Walton Lillehei Yo​ung Investigator's Award. 14th Annual Meeting of Asian Society for Cardiovascular Surgery. Osaka, Japan, Jun 1st - 3rd (2006)
  • Shortlist for Vivien Thomas Young Investigator Competition. Annual Scientific Session of American Heart Association of American. Chicago, USA. Nov 12th - 15th (2006) 
  • Travel award of Basic Research Council. American Heart Association Scientific Session 2011. Orlando, USA. Nov 12th - 16th (2011)


  • NMRC Clinician Scientist Individual Research Grant (PI: Dr Ye Lei) ‘Synergy between Thymosin B4 and Cardiomyocytes for Cardiac protection, regeneration and metabolism’
  • NMRC Open Fund Individual Research Grant (PI: Dr Ye Lei) 'Myocardial regeneration of neonatal pig'