Our Group uses state-of-the-art approaches to discover genes that cause heart and artery diseases. We do this by integrating advanced cardiovascular phenotyping with molecular datasets to derive novel insights into human disease. The Group has a particular interest in understanding the disease mechanisms that cause systolic and diastolic heart failure due genetic and genomic triggers. The overall aim of our research is to identify new ways of preventing, diagnosing, stratifying and treating patients with cardiovascular disease.
The Group has strong collaborations with Duke-NUS, Imperial College (UK), Max Delbruck Centre (Germany) and Harvard Medical School (USA). The group uses bioinformatics, next generation sequencing approaches, iPSC technology, rodent models of disease, cell and molecular biology and applied cardiovascular physiology to address areas of clinical need.
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