The Cardiovascular Bioengineering (CB) Theme aims to (1) advance scientific understanding of the mechanical function of the heart and blood vessels, in health and disease; and (2) develop innovative technologies in cardiovascular diagnosis and treatment. The team comprises biomedical engineers (NHCS, A*STAR) and clinical investigators (NHCS, NUHS and KKH) from many institution island-wide. We apply advanced experimental and computational models with emphasis on quantitative evaluation of the relevant parameters by integrating multidisciplinary approaches (cardiac imaging, mechanics, physiology and computational cardiology) that we hope shall ultimate translate into discoveries with practical clinical application.
Core elements of the theme are: (1) multi-disciplinary expertise in cardiovascular imaging, mechanics, engineering and physiology) for innovation; (2) curated library of subject-specific cardiovascular images and computational models; (3) in-house computational expertise for UI development and data management; and (4) established technology development pathways and processes.
Research area includes fluid dynamics and mechanics of blood in coronary arteries and their roles in atherosclerosis and arterial remodeling (i.e., Projects 1, and 4) and in ventricles (i.e., Project 2). Cardiac imaging (i.e. Cardiac MR, Echocardiography, CTA and QCA) research (i.e., Project 2 and 3) involves the development of in-house software with emphasis on quantitative evaluation of the ventricular systolic and diastolic and synchrony parameters. Cardiovascular solid mechanics research addresses the mechanical stress and strain in healthy and disease hearts (Project 5). Novel sensor technologies that is for early detection of the heart dysfunction and follow-up of the disease progression.
1. Noninvasive fractional flow reserve (FFRb) in intermediate coronary artery disease (supported by National Medical Research Council, Bench-to-Bedside Program)
2. Integrated computational modelling of right heart mechanics and dynamics in congenital heart disease (INITIATE study) (supported by National Medical Research Council)
3. Curvedness-based imaging in heart failure (supported by A*STAR SERC)
4. CABG restenosis (supported by Singhealth Foundation)
5. Pulmonary hypertension: Image based multi-scale modeling of the cardio-pulmonary system (Supported by Goh Foundation)
6. E-stethoscope (Supported by A*STAR SERC)
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