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Assoc Prof Ye Lei

Assoc Prof Ye Lei


National Heart Centre Singapore


Associate Professor Ye Lei graduated with a medical degree from the Shanghai Medical University, Shanghai, China in 1996. He received his PhD from the Faculty of Medicine, National University of Singapore (NUS) in 2005. After completion of his PhD, Assoc Prof Ye continued his research at NUS and was promoted to Senior Research Scientist in July 2010. In Sept 2010, Assoc Prof Ye received an invitation for a position at the University of Minnesota, USA, as was appointed an Assistant Professor there. He returned to Singapore to join the National Heart Centre Singapore in Nov 2014. 

Assoc Prof Ye interest lies in the fields of cardiovascular research. He has published more than 60 papers in peer-reviewed journals, including European Journal of Heart Failure, Diabetologia, Biomaterials, Circulation Research, Circulation, and Cell Stem Cell. His research has received various national and international awards at prestigious scientific congresses, including Singapore Cardiac Society (2006, 2007, 2009), Asian Society for Cardiovascular Surgery (2004-2006), Asian Pacific Congress of Cardiology (2009), European Society of Cardiovascular Surgery (2005), European Society of Cardiology (2007), and American Heart Association (2006 & 2011). He was on the final shortlist for the Vivien Thomas Young Investigator Competition at the Annual Scientific Session of American Heart Association in 2006. 


  • ​​Medical degree from the Shanghai Medical University, Shanghai, China in 1996
  • PhD from the Faculty of Medicine, National University of Singapore (NUS) in 2005

Professional Appointments and Committee Memberships

  • ​Principal Investigator, National Heart Research Institute Singapore, National Heart Centre Singapore
  • Associate Professor, Duke-NUS Medical School, 2019 to Present
  • Associate Professor, Department of Biomedical Engineering (BME), The University of Alabama at Birmingham
  • Panel member, OF-YIRG, NMRC, 2019-2020​


  • Singhealth Publish! Award 2018. Ye L. Singhealth Research, 2019
  • Travel award of Basic Research Council. American Heart Association Scientific Session 2011. Orlando, USA. Nov 12th - 16th, 2011
  • Shortlist for Vivien Thomas Young Investigator Competition. Annual Scientific Session of American Heart Association of American. Chicago, USA. Nov 12th - 15th, 2006 
  • C Walton Lillehei Young Investigator's Award. 14th Annual Meeting of Asian Society for Cardiovascular Surgery. Osaka, Japan, Jun 1st - 3rd, 2006
  • Rabago Prize Award. The 54th International Congress for European Society of Cardiovascular Surgery. Athens Greece, May 19th - 22nd, 2005
  • NMRC Clinician Scientist Individual Research Grant (PI: Dr Ye Lei) ‘Synergy between Thymosin B4 and Cardiomyocytes for Cardiac protection, regeneration and metabolism’
  • NMRC Open Fund Individual Research Grant (PI: Dr Ye Lei) 'Myocardial regeneration of neonatal pig'
  • Duke / Duke-NUS Research Collaboration Pilot Project. (Duke-NUS: PI Dr. Ye Lei). BacNav Gene Therapy for Myocardial Infarction in Cynomolgus Macaques

Research Interests

  • Molecular and cellular therapeutics for heart regeneration
  • Molecular and cellular therapeutics for treatment of ischemic heart disease


  • Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction. Tao ZH, Loo SJ, Su LP, Tan SH, Tee GZ, Gan SU, Zhang JY, Chen X, Ye L*. Cardiovascular Research. 14 Jul., 2020 online.
  • Dexamethasone inhibits regeneration and causes ventricular aneurysm in the neonatal porcine heart after myocardial infarction. Tao ZH, Loo SJ, Su LP, Abdurrachim D, Lalic J, Lee TH, Chen X, Tan RS, Zhang JY, Ye L*. Journal of Molecular and Cellular Cardiology 2020 Jul., 144: 15-23. (Editor’s Choice Article)
  • Transplantation of Endothelial Progenitor Cells in obese diabetic rats following myocardial infarction: role of Thymosin Beta-4. Poh KK, Lee PS, Djohan AH, Galupo MJ, Songco GG, Yeo TC, Tan HC, Richards MA, Ye L*. Cells 2020, 9(4): 949. doi:10.3390/cells9040949
  • Circ Res. 2019 Jan.; Berry JL,Zhu WQ, Tang YL, Krishnamurthy P, Ge Y,Cooke JP, Chen YB, Garry DJ, Yang HT,Rajasekaran NS,Koch WJ,Li S, Domae K, Qin GJ, Cheng K, Kamp TJ, Ye L, Hu SJ, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD,Liao RL, Pu WT, Wang YB,Ping PP, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang JY. 124(1): 161-169.
  • Early regenerative capacity in the porcine heart. Ye L*, D'Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, Tee GZ, Pua CJ, Pena EM, Cheng RB, Chen WC, Abdurrachim D, Lalic J, Tan RS, Lee TH, Zhang JY, Cook SA. Circulation 2018 Dec.;138(24): 2798-2808. 
  • The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Su LP, Kong XC, Lim SY, Loo SJ, Tan SH, Poh KK, Dutton J, Stewart C, Cook S, Su XF, Ma JH, Zhang JY, Ye L*. Stem Cell Research and Therapy. 15 Nov. 2018. 9:313.
  • Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Ye L, Chang YH, Xiong Q, Zhang PY, Zhang LY, Somasundaram P, Lepley M, Swingen C, Su LP, Wendel JS, Guo J, Jang A, Rosenbush D, Greder L, Dutton JR, Zhang JH, Kamp TJ, Kaufman DS, Ge Y, Zhang JY. Cell Stem Cell 2014; 15(6): 750-761.

    *: Corresponding author

Research Trials

  • Updated on 2020-08-18T16:00:00Z