14 Nov 2017
Singapore scientists make a major breakthrough to treat fibrotic diseases that cause organ impairment and failure

Researchers from the Duke-NUS, led by principal investigator Professor Stuart Cook, discovered that a protein, interleukin 11, or IL11, is the main protein activating and speeding up the processes of kidney and heart failure. The research started five years ago with researchers experimenting on donated heart tissue samples of 84 patients from the NHCS in 2016. The discovery paves the way for more effective treatment against fibrosis, where the body produces excessive connective tissue in response to an injury, causing tissue scarring. "Currently, over 225 million people suffer from a heart or kidney failure," said Prof Terrance Chua, Medical Director of the NHCS. There is currently no treatment to prevent fibrosis, he added. More Singaporeans, especially, suffer from the three most common diseases that lead to heart failure - coronary heart disease, hypertension and diabetes - as compared to other Asians, American and Europeans. This could be due to genetic reasons, said Prof Stuart Cook, Director of the Duke-NUS Programme in Cardiovascular and Metabolic Disorders and the Tanoto Foundation Professor of Cardiovascular Medicine.

Click here to read the media release.

28 Aug 2017
Breakthrough discovery presents hope for treating fibrotic diseases which cause organ impairment

A breakthrough translational research led by Professor Stuart Cook and Assistant Professor Sebastian Schafer, both from National Heart Centre Singapore and Duke-NUS' Cardiovascular & Metabolic Diseases Programme, has discovered the key drivers of chronic fibrotic disease in heart, kidney and other tissues.

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13 Jul 2017
Low Utilisation Of Implantable Cardioverter Defibrillators (ICDs)

Principal Investigator Professor Carolyn Lam, Senior Consultant, Department of Cardiology at the National Heart Centre Singapore and Professor, Duke-NUS Cardiovascular Academic Clinical Program, and her co-investigators of a multinational data study on Asian heart failure patients found that utilisation rates of Implantable Cardioverter Defribrillators (ICDs) was low in Asian patients despite data having shown that ICDs reduced risks of all-cause mortality and sudden cardiac deaths.

Click to read the media release.

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